Protein Alignment Mhc and myo-5

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_505094.1
• Gene: myo-5 / 179190
• WormBaseID: WBGene00019064
• Length: 1974
• Species: Caenorhabditis elegans
• Alignment Length: 1958
• Identity: 1083/1958 - (55%)
• Similarity: 1446/1958 - (73%)
• Gaps: 20/1958 - (1%)

  Fly    10 DEDP-TPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIK 73
            :.|| ..:|..|.||.....:|.:||||:.|:.|.:||::..|||::|||.|.|....|..:.||
 Worm     4 EADPGWQFLRQSPEQLLAATTKKFDSKKNVWVADPEEGFIAAEIKSSKGDTVVVVTSKGVEKTIK 68

  Fly    74 SEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNR 138
            .:..:::||||:||.||||::|.||...||||||||||:.:||||||||||.||||||.|:|:..
 Worm    69 KDDAQQMNPPKYEKTEDMANLTFLNDASVLHNLRQRYYSMMIYTYSGLFCVVINPYKRLPIYSES 133

  Fly   139 CAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS- 202
            ..:||.||||||:|||:||:||.||.:|..:..||||||||||||||||||||||:|||.||||
 Worm   134 VCQMYLGKRRNEMPPHLFAVSDEAYRNMTNDRENQSMLITGESGAGKTENTKKVISYFAMVGASQ 198

  Fly   203 ---KKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIET 264
               ||..:..|::.|||||:||||||||||||||||||:|||||||||||||...||:||||||.
 Worm   199 QSNKKKSKKDKAQVSLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNTGGKVAGADIEH 263

  Fly   265 YLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFS 329
            |||||:|||.|...||||||||||.|.:|.|:::...||..|.:|..|||.:||:..:||.||..
 Worm   264 YLLEKSRVIKQAPGERSYHIFYQIYSDAVKGLREKLFLTRPIKEYTFVSQAEVTIDGVDDKEEML 328

  Fly   330 LTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAEL 394
            :||:||||:.||..||.:::.|||.:||||.:|||||.||||||.:..:||....||:..::.:.
 Worm   329 ITDEAFDIMKFTATEKSELFAITAGIMHMGELKFKQRPREEQAELEEGKEGELACKLYCVESEKF 393

  Fly   395 YKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQ-KRQHFIGV 458
            ...|||||:|||.|:|.:|:|:.||..::|||.|.:|.|:|.||:::||:|||.|. .|..||||
 Worm   394 INALLKPRVKVGTEWVNKGQNLDQVNWAVGALAKALFARMFSWLIRRCNKTLDAQDLSRDFFIGV 458

  Fly   459 LDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI 523
            |||||||||:.|.||||.|||.|||||||||||||||||||||||||.|.|||||:||.|||:||
 Worm   459 LDIAGFEIFDLNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYKREGIQWEFIDFGLDLQACIELI 523

  Fly   524 EKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSY 588
            |||:||:|:|:||.:.|||:|.|.:.||.:.||||...||||:|||..|..||.||.||||.|.|
 Worm   524 EKPLGIVSMLDEECIVPKASDLTLASKLNDQHLGKHPNFQKPRPPKGKQAEAHLAIVHYAGTVRY 588

  Fly   589 NITGWLEKNKDPLNDTVVDQFKKSQ-NKLLIEIFADHAGQSGGGEQAKGGR---GKKGG---GFA 646
            |:.|||||||||||||.|...|.:: |:|:.:::||:|.|......||.|:   |||.|   .|.
 Worm   589 NVKGWLEKNKDPLNDTAVTVLKANKGNQLMADLWADYATQEDVAAAAKDGKKAVGKKKGKSASFM 653

  Fly   647 TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFP 711
            |||..|:|.||.||..|..|.|||:|||||||:|:.|::||:||::|||||||||||||||||||
 Worm   654 TVSMMYRESLNKLMHMLHQTHPHFIRCIIPNELKKAGMIDANLVLNQLTCNGVLEGIRICRKGFP 718

  Fly   712 NRMMYPDFKMRYKIMCPKLLQGVEKDKKATE----IIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            |||.:.|||.||.::.....:..:..|.|.|    .:||...|.:::::.|.|||||:||||..:
 Worm   719 NRMPFLDFKQRYAVLAADAAKAGKDPKDAGEKISAALIKDGSLKQEEFQCGLTKVFFKAGVLAHL 783

  Fly   773 EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKP 837
            ||.|||.|||||:..|...|.||::..:|:..:|:|.|.|:|||:|.:..||:|.|:||:.:|||
 Worm   784 EELRDEALGKIMAKFQCACRHYLAQCEYKRKLDQKVGLIVLQRNIRAWCTLRSWSWFKLFGRVKP 848

  Fly   838 LLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQE 902
            |:..|:..:|...||:|.|..||....|.:.||::||.||:|.|||.|||..|..|:.:..:.:|
 Worm   849 LIKGSKKNEEFEALEKKFKVLEEEKTQEERKRKDMEAENARLEAEKQALLIQLEQERDSSAEGEE 913

  Fly   903 RNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDK 967
            |:|||.|||.|||.|:.::.::|..||:....|.:||||.:|:..||||.:.|||..::|.|.:|
 Worm   914 RSAKLLAQKADLEKQMANMNDQLCDEEEKNAALTKQKKKIEQDNEGLKKTVSDLETTIKKQESEK 978

  Fly   968 ATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDE 1032
            ..||||||:|.|||..|||:|:|||||||.|.|.|:|..|::||.|||:|||||.|||||.||||
 Worm   979 QAKDHQIRSLQDEIQSQDEVISKLNKEKKHQEEVNRKLLEDIQAEEDKVNHLNKTKAKLESTLDE 1043

  Fly  1033 LEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQ 1097
            |||:|||||:.|.|.||.:|||||:||:.||.:.:|.|:|.|.||.|::||.|||||.::|||||
 Worm  1044 LEDTLEREKRGRQDCEKQRRKVEGELKIAQELIEELNRHKHEQEQVIKKKDIELSSIQSRLEDEQ 1108

  Fly  1098 VVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIEL 1162
            .:|.|.|||||||.|||:|||||::|||.:|:||||.|.::..||||||:||:||||||.|||||
 Worm  1109 SLVAKLQRQIKELLARIQELEEELDAERNSRSKAEKARNEMQMELEELGDRLDEAGGATQAQIEL 1173

  Fly  1163 NKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQL 1227
            ||||||||:|||:|||:|.|..|:::|.|||||||||||:::|:|.:.|::.|.|:|||:...::
 Worm  1174 NKKREAELAKLRQDLEDAAINSETSMAALRKKHNDAVAELSDQLDTIQKMRGKLEREKNDKQREV 1238

  Fly  1228 NDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEE 1292
            ::|:...|....::...|::||||:..|.::..|.||..|.:.:....|.|:..||.||.||||:
 Worm  1239 DELQQSADVEAKQRQNCERMAKQLEAQLTDMTLKSDEQARLIQELTMGKNKVHNENQDLNRQLED 1303

  Fly  1293 AESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQ 1357
            ||:|:..|::||....:|||:.||..|:|:|||.:|..:..|.:.:.:..||.:|||.:.|.|:|
 Worm  1304 AEAQLCALNRIKQQQHSQLEELKRTLDQETRERQSLHSQVSNYQLECEQFRESLEEEQDAKTDVQ 1368

  Fly  1358 RQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLST 1422
            |||||||:|.|.||:|:|.:||:|:|||||.:|||..::.|.:|.:|:.|||...|||.||||:.
 Worm  1369 RQLSKANSEIQQWRAKFEGEGVSRAEELEETRRKLTHKVQEMQEQLENANQKIGTLEKNKQRLAH 1433

  Fly  1423 EVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAY 1487
            ::||.|::.||||:||::.|||||.|||::.||:.|.:.|.||::.||:|.|..:||.|||:...
 Worm  1434 DLEDAQVDADRANSIASSLEKKQKGFDKVLDEWRRKCEALVAEVEQSQRETRAAATETFRLRNQL 1498

  Fly  1488 EEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQ 1552
            ||..||.|||:||||.||.|:||:.||:||||:::|:::|.|:|||.||:|||.||:|||.|||.
 Worm  1499 EESGEQTEAVKRENKALAQELKDIADQLGEGGKSVHDLQKMRRRLEIEKEELQQALDEAECALEA 1563

  Fly  1553 EENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKL 1617
            ||.||:|||:|:||:|.||::|:||||||||||||||.|.::|||.|||.|::|:||.|:.||||
 Worm  1564 EEAKVMRAQIEVSQIRSEIEKRLQEKEEEFENTRKNHSRTIESMQVSLETESRGRAELLKTKKKL 1628

  Fly  1618 EADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQN 1682
            |.|:|||||||||:||.|.:.||::|:.|..::::|..:|||||:..::|:...::|||:..||.
 Worm  1629 EGDVNELEIALDHSNKLNVDGQKSMKKLQDTIRELQYQVEEEQRSLSESRDHANLAERRSQVLQQ 1693

  Fly  1683 ELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEA 1747
            |.|:...:.||::|.|||||.|||:..:.:||:|..|:.:.|.|||:|.:||.|.|:::|.:::|
 Worm  1694 EKEDLAIIYEQSERTRRQAELELAEVKDSVNELSNSNSLLLATKRKVEGDLQLLQSEIEEAMSDA 1758

  Fly  1748 KNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQ 1812
            |.|:||||||::||::||||||:||:||....:.:|.||.|:|:||:|||||||..:||||:.:.
 Worm  1759 KTSDEKAKKAIMDASKLADELRSEQEHASNLNQSKKTLESQVKDLQMRLDEAEAAGIKGGKRQLA 1823

  Fly  1813 KLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTY 1877
            ||:.|:.|||.||:||.||||:.||.||..:|:.:||.||.:||:|:.|||.||::|||||||||
 Worm  1824 KLDMRIHELETELEGENRRHAETQKVLRNKDRKCRELQFQVDEDKKSQERMYDLIEKLQQKIKTY 1888

  Fly  1878 KRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR--AGSVG-RGASPAPRAT 1939
            |||||:||.:|:.||||:|:.|..:|:|:||||.||.|:.|.|.|||  :|..| ||.:.:...|
 Worm  1889 KRQIEDAESLASGNLAKYRQLQHVVEDAQERADAAENALQKLRLKGRSTSGVFGPRGLAHSMSTT 1953

  Fly  1940 SVRPQFDG 1947
            .|..:..|
 Worm  1954 GVNMRRGG 1961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	14/36 (39%)
		MYSc	81..777	CDD:214580	431/711 (61%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	411/680 (60%)
		Myosin_tail_1	842..1897	CDD:279860	572/1054 (54%)
		V_Alix_like	1557..1877	CDD:187408	175/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	49/99 (49%)
		TMPIT	1739..>1825	CDD:285135	46/85 (54%)
myo-5	NP_505094.1	Myosin_N	31..68	CDD:280832	14/36 (39%)
		Myosin_head	83..776	CDD:278492	418/692 (60%)
		MYSc_class_II	95..776	CDD:276951	411/680 (60%)
		Myosin_tail_1	853..1933	CDD:279860	585/1079 (54%)
		DUF4795	954..1129	CDD:292662	109/174 (63%)
		Prefoldin	1111..1243	CDD:298833	83/131 (63%)
		Tmemb_cc2	<1212..1322	CDD:287269	37/109 (34%)
		DUF881	1746..>1838	CDD:303034	50/91 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I24
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2227	1.000	Inparanoid score	I15
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm14456
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830