Protein Alignment Mhc and Myo5b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_006525777.1
• Gene: Myo5b / 17919
• MGIID: 106598
• Length: 1849
• Species: Mus musculus
• Alignment Length: 2062
• Identity: 567/2062 - (27%)
• Similarity: 904/2062 - (43%)
• Gaps: 450/2062 - (21%)

  Fly    29 SKPYDSKKSCWIPDEKEGYLLGEIKATK----GD-----------IVS--VGLQGGETRDLKKDL 76
            |:.|......||||..|.:...|:  ||    ||           |:.  |.:|..:...|:
Mouse     4 SELYTRYTRVWIPDPDEVWRSAEL--TKDYKEGDKSLQLRLEDDTILEYPVDVQNNQVPFLR--- 63

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYY-NKLIYTYSGLFCVAINPYKRYPVYTNRCA 140
                ||.......|::.|::|::.:|||||:.|:. :..||||.|:..||||||::.|:|.....
Mouse    64 ----NPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVI 124

  Fly   141 KMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKT 205
            ..|.|:...::.|||||:::.||..|..:..|||::::||||||||.:.|..:.||||||.|
Mouse   125 YAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS--- 186

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
                .|..::|::|:.::|::||.|||||.||||||||||||.|.|.....:.||::.||||||:
Mouse   187 ----ASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKS 247

  Fly   271 RVISQQSLERSYHIFYQI-MSGSVPGVKDICL--LTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:.|...||:||||||: .:.|:|..|::.|  ..|..|..|   .|..|:..::||::|..|.
Mouse   248 RVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAH---GGNTTIEGVNDADDFEKTR 309

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG--------EEEGGRVSKLFGC 389
            ||..:||.....:..:::|.|:::|:|.:       |.|:|:||        :|.......|.|.
Mouse   310 QALTLLGVRDSHQISIFKIIASILHLGSV-------EIQSERDGDSCSISPQDEHLSNFCSLLGI 367

  Fly   390 DTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQH 454
            :.:::...|...::...:|...:..::|||.|:..||.|.::.:||.|:|:..|:.|.|..|:..
Mouse   368 EHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFSWIVEHINKALHTSLKQHS 432

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLC 519
            |||||||.|||.||.|.|||.|||:.||||||.||.|:|.||||||.:|.|.||.||| .|.|.|
Mouse   433 FIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDF-YDNQPC 496

  Fly   520 IDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAG 584
            |||||..:|||.:|:||...||.|||.:::||...| ..|..||||:     .....|.:.|:|.
Mouse   497 IDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYERH-SNSQHFQKPR-----MSNTAFIVNHFAD 555

  Fly   585 CVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG---------- 639
            .|.|...|:||||:|.:.:..::..|.|:..|:.::|.|....:.....||....
Mouse   556 KVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDSAPATNTAKNRSSSKINVRSSRP 620

  Fly   640 ---------KKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLT 695
                     ||..|:     .::..||.||.||.:|.||:||||.||:.|.|...|....:.||.
Mouse   621 LIKVPNKEHKKSVGY-----QFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLR 680

  Fly   696 CNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL-LQGVEKDKKATEIIIKFIDLPEDQYRLGN 759
            ..||||.|||...|:|:|..|.||..||:::..|. |...:|......::...|..| |:::.|.
Mouse   681 ACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNICKSVLESLIKDP-DKFQFGR 744

  Fly   760 TKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLR 824
            ||:|||||.:..:|:.|.::..:....:|...||:|.|..:::|   |.|...:||..|.||
Mouse   745 TKIFFRAGQVAYLEKLRADKFREATIMIQKSVRGWLQRVKYRRL---RAATLSLQRFCRGYL--- 803

  Fly   825 TWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNA----KLLAEKTA 885
                                   ..||.|..::..    |.:..:|:...|.|    :.:...|.
Mouse   804 -----------------------ARRLAEHLRRTR----AAIVFQKQYRMLKARRAYRRVCRATV 841

  Fly   886 LLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRD--IQERLTQEEDAR--NQLFQQKKKADQEI 946
            ::.|.:......::|  |...:..:...::...|.  .::|..:|.||.  .|...::.||.||:
Mouse   842 IIQSFTRAMFVRRNY--RQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCAFRRLKARQEL 904

  Fly   947 SGLKKDIEDLE----LNV---QKAEQDKATKDHQ---IRNLNDEI-----AHQDELINKLNKEKK 996
            ..||.:....|    |||   .|..|.:...|.|   .:.|::::     :|..| :.||.|| .
Mouse   905 KALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSSHAVE-VEKLKKE-L 967

  Fly   997 MQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLT 1061
            ...:.||:....||               |::.:..|...|::....|..:|.:..|..|:|:
Mouse   968 AHYQQNQEADTSLQ---------------LQEEVQSLRTELQKAHSERRVLEDAHNKENGELR-- 1015

  Fly  1062 QEAVADLE------RNKKE-LEQTIQRKDKELSS---------ITAKLEDEQVVVLKHQRQIKE- 1109
             :.|||||      :::|| |...|..:.|..||         :..:||:|:   .::|..:||
Mouse  1016 -KRVADLEHENALLKDEKEYLNNQILCQSKAESSQSSVEENLLMKKELEEER---SRYQNLVKEY 1076

  Fly  1110 --LQARIEELEEEVEAERQA---RAKAEKQRA-------------------DLARELEELGERLE 1150
              |:.|.|.|.:||...:|.   |.....|.:                   |..:::||:|  :|
Mouse  1077 SQLEQRYENLRDEVTILKQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIG--IE 1139

  Fly  1151 EAGGATSAQIELNKK---REAELSKLRRDLEEANIQHESTLANLRKKHN----DAVAEMAEQVDQ 1208
            :|....:..::|.|:   .|.|..||:..||:.  |.:|....:.:::|    |..|::|....:
Mouse  1140 KAAMDMTVFLKLQKRVRELEQERKKLQAQLEKG--QQDSKKGQVEQQNNGLDVDQDADIAYNSLK 1202

  Fly  1209 LNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFD 1273
            ..:|:::.:|.||:    ||:||..|    .::|.|:          |...|..|..:..||...
Mouse  1203 RQELESENKKLKND----LNELRKAV----ADQAMQD----------NSTHSSPDSYSLLLNQLK 1249

  Fly  1274 ASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL--EDTKRLADEESRERATLLGKFRNLE 1336
            .:.::|.:...::|                  .|.||:  .|.:||:.:...........:.|.|
Mouse  1250 LANEELEVRKEEVL------------------ILRTQIMNADQRRLSGKNMEPNINARTSWPNSE 1296

  Fly  1337 HDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQ--ARLAEA 1399
            ..:|  :|...|...|       :.:.|::.:.| .....||     ||..|.:.|:  |||.||
Mouse  1297 KHVD--QEDAIEAYHG-------VCQTNSQTEDW-GYLNEDG-----ELGLAYQGLKQVARLLEA 1346

  Fly  1400 EETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAA 1464
            :...:||..     |:..:.|..:||.|:.|:|          |:|:.|
Mouse  1347 QLQAQSLEH-----EEEVEHLKAQVEALKEEMD----------KQQQTF---------------- 1380

  Fly  1465 ELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKAR 1529
                    |:   |.|...:...|.|.:| |..|..|:||  :.|:|::::.:..|      |.:
Mouse  1381 --------CQ---TLLLSPEAQVEFGVQQ-EISRLTNENL--DFKELVEKLEKNER------KLK 1425

  Fly  1530 KRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRR--IQEKEEEFENTRKNHQRA 1592
            |:|:....::|..  ||..||.|.:.:           ..|:.|:  :|.||::|:...:.|:..
Mouse  1426 KQLKIYMKKVQDL--EAAQALAQSDRR-----------HHELTRQVTVQRKEKDFQGMLEYHKED 1477

  Fly  1593 LDSMQASLEAEAKGKA------------------------EALRMKKKLEADINELEIALDHANK 1633
            ...:..:|..:.|.:.                        :.|::...|.:.||.::..|   .|
Mouse  1478 EALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVL---KK 1539

  Fly  1634 ANAEAQ------KNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQN-ELEESRTLL 1691
            .|.:.:      .|..|:...||         |.:.|:.......:::..:.|:| :|.|.|.:|
Mouse  1540 HNDDFEMTSFWLSNTCRFLHCLK---------QYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVL 1595

  Fly  1692 EQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKK 1756
            ....   .|..|:|....|.|    .|...:||   .||:|      .:..|.........|...
Mouse  1596 SDLS---IQIYQQLIKIAEGL----LQPMIVSA---MLENE------SIQGLSGVRPTGYRKRSS 1644

  Fly  1757 AMVDAAR------LADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAI---- 1811
            :|||...      :..::.:.......|....:.:.|..|:|...::....|.|...|.|.
Mouse  1645 SMVDGENSYCLEAIVRQMNSFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWST 1709

  Fly  1812 -QKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDK---LQQ 1872
             .:|...:.:||..|.|         |||.:|..               .:.|:.|:..   ||.
Mouse  1710 GMQLRYNISQLEEWLRG---------KNLHQSGA---------------VQTMEPLIQAAQLLQL 1750

  Fly  1873 KIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLA 1912
            |.||:    |:||.|.:|       .:.|.......|.|.|||..::
Mouse  1751 KKKTH----EDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVS 1793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/58 (24%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	273/696 (39%)
		Myosin_tail_1	842..1922	CDD:460256	254/1200 (21%)
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	427/1393 (31%)
		MYSc_Myo5	83..750	CDD:276831	273/696 (39%)
		EnvC	1202..>1441	CDD:443969	74/342 (22%)
		Myo5b_CBD	1475..1846	CDD:271261	72/375 (19%)