DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myo5b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006525777.1 Gene:Myo5b / 17919 MGIID:106598 Length:1849 Species:Mus musculus


Alignment Length:2055 Identity:564/2055 - (27%)
Similarity:903/2055 - (43%) Gaps:436/2055 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SKPYDSKKSCWIPDEKEGYLLGEIKATK----GD-IVSVGLQGGEVR----DIKSEKVEKV-NPP 83
            |:.|......||||..|.:...|:  ||    || .:.:.|:...:.    |:::.:|..: ||.
Mouse     4 SELYTRYTRVWIPDPDEVWRSAEL--TKDYKEGDKSLQLRLEDDTILEYPVDVQNNQVPFLRNPD 66

  Fly    84 KFEKIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKR 147
            ......|:..::.|:.|.|||||:.|:. :..||||.|:..||||||::.|:|.......|.|:.
Mouse    67 ILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQN 131

  Fly   148 RNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSK 212
            ..::.|||||:::.||..|..:..|||::::||||||||.:.|..:.||||||.|       .|.
Mouse   132 MGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------ASD 189

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
            .::|::|:.::|::||.|||||.||||||||||||.|.|.....:.||::.||||||:||:.|..
Mouse   190 TNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQAD 254

  Fly   278 LERSYHIFYQI-MSGSVPGVKDICL--LTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILG 339
            .||:||||||: .:.|:|..|::.|  ..|..|..|   .|..|:..::||::|..|.||..:||
Mouse   255 DERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAH---GGNTTIEGVNDADDFEKTRQALTLLG 316

  Fly   340 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG--------EEEGGRVSKLFGCDTAELYK 396
            .....:..:::|.|:::|:|.:       |.|:|:||        :|.......|.|.:.:::..
Mouse   317 VRDSHQISIFKIIASILHLGSV-------EIQSERDGDSCSISPQDEHLSNFCSLLGIEHSQMEH 374

  Fly   397 NLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDI 461
            .|...::...:|...:..::|||.|:..||.|.::.:||.|:|:..|:.|.|..|:..|||||||
Mouse   375 WLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFSWIVEHINKALHTSLKQHSFIGVLDI 439

  Fly   462 AGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP 526
            .|||.||.|.|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||||||..
Mouse   440 YGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAK 503

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            :|||.:|:||...||.|||.:::||...| ..|..||||:     .....|.:.|:|..|.|...
Mouse   504 LGILDLLDEECKVPKGTDQNWAQKLYERH-SNSQHFQKPR-----MSNTAFIVNHFADKVEYLSD 562

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG----------------- 639
            |:||||:|.:.:..::..|.|:..|:.::|.|....:.....||....                 
Mouse   563 GFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDSAPATNTAKNRSSSKINVRSSRPLIKVPNK 627

  Fly   640 --KKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEG 702
              ||..|:     .::..||.||.||.:|.||:||||.||:.|.|...|....:.||...||||.
Mouse   628 EHKKSVGY-----QFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLET 687

  Fly   703 IRICRKGFPNRMMYPDFKMRYKIMCPKL-LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA 766
            |||...|:|:|..|.||..||:::..|. |...:|......::...|..| |:::.|.||:||||
Mouse   688 IRISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNICKSVLESLIKDP-DKFQFGRTKIFFRA 751

  Fly   767 GVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKL 831
            |.:..:|:.|.::..:....:|...||:|.|..:::|   |.|...:||..|.||          
Mouse   752 GQVAYLEKLRADKFREATIMIQKSVRGWLQRVKYRRL---RAATLSLQRFCRGYL---------- 803

  Fly   832 WQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNA----KLLAEKTALLDSLSG 892
                            ..||.|..::..    |.:..:|:...|.|    :.:...|.::.|.:.
Mouse   804 ----------------ARRLAEHLRRTR----AAIVFQKQYRMLKARRAYRRVCRATVIIQSFTR 848

  Fly   893 EKGALQDYQERNAKLTAQKNDLENQLRD--IQERLTQEEDAR--NQLFQQKKKADQEISGLKKDI 953
            .....::|  |...:..:...::...|.  .::|..:|.||.  .|...::.||.||:..||.:.
Mouse   849 AMFVRRNY--RQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCAFRRLKARQELKALKIEA 911

  Fly   954 EDLE----LNV---QKAEQDKATKDHQ---IRNLNDEI-----AHQDELINKLNKEKKMQGETNQ 1003
            ...|    |||   .|..|.:...|.|   .:.|::::     :|..| :.||.|| ....:.||
Mouse   912 RSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSSHAVE-VEKLKKE-LAHYQQNQ 974

  Fly  1004 KTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADL 1068
            :....||               |::.:..|...|::....|..:|.:..|..|:|:   :.||||
Mouse   975 EADTSLQ---------------LQEEVQSLRTELQKAHSERRVLEDAHNKENGELR---KRVADL 1021

  Fly  1069 E------RNKKE-LEQTIQRKDKELSS---------ITAKLEDEQVVVLKHQRQIKE---LQARI 1114
            |      :::|| |...|..:.|..||         :..:||:|:   .::|..:||   |:.|.
Mouse  1022 EHENALLKDEKEYLNNQILCQSKAESSQSSVEENLLMKKELEEER---SRYQNLVKEYSQLEQRY 1083

  Fly  1115 EELEEEVEAERQA---RAKAEKQRA-------------------DLARELEELGERLEEAGGATS 1157
            |.|.:||...:|.   |.....|.:                   |..:::||:|  :|:|....:
Mouse  1084 ENLRDEVTILKQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIG--IEKAAMDMT 1146

  Fly  1158 AQIELNKK---REAELSKLRRDLEEANIQHESTLANLRKKHN----DAVAEMAEQVDQLNKLKAK 1215
            ..::|.|:   .|.|..||:..||:.  |.:|....:.:::|    |..|::|....:..:|:::
Mouse  1147 VFLKLQKRVRELEQERKKLQAQLEKG--QQDSKKGQVEQQNNGLDVDQDADIAYNSLKRQELESE 1209

  Fly  1216 AEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLS 1280
            .:|.||:    ||:||..|    .::|.|:          |...|..|..:..||....:.::|.
Mouse  1210 NKKLKND----LNELRKAV----ADQAMQD----------NSTHSSPDSYSLLLNQLKLANEELE 1256

  Fly  1281 IENSDLLRQLEEAESQVSQLSKIKISLTTQL--EDTKRLADEESRERATLLGKFRNLEHDLDNLR 1343
            :...::|                  .|.||:  .|.:||:.:...........:.|.|..:|  :
Mouse  1257 VRKEEVL------------------ILRTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVD--Q 1301

  Fly  1344 EQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQ--ARLAEAEETIESL 1406
            |...|...|       :.:.|::.:.| .....||     ||..|.:.|:  |||.||:...:||
Mouse  1302 EDAIEAYHG-------VCQTNSQTEDW-GYLNEDG-----ELGLAYQGLKQVARLLEAQLQAQSL 1353

  Fly  1407 NQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQK 1471
            ..     |:..:.|..:||.|:.|:|          |:|:.|                       
Mouse  1354 EH-----EEEVEHLKAQVEALKEEMD----------KQQQTF----------------------- 1380

  Fly  1472 ECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEK 1536
             |:   |.|...:...|.|.:| |..|..|:||  :.|:|::::.:..|      |.:|:|:...
Mouse  1381 -CQ---TLLLSPEAQVEFGVQQ-EISRLTNENL--DFKELVEKLEKNER------KLKKQLKIYM 1432

  Fly  1537 DELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRR--IQEKEEEFENTRKNHQRALDSMQAS 1599
            .::|..  ||..||.|.:.:           ..|:.|:  :|.||::|:...:.|:.....:..:
Mouse  1433 KKVQDL--EAAQALAQSDRR-----------HHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRN 1484

  Fly  1600 LEAEAKGKA------------------------EALRMKKKLEADINELEIALDHANKANAEAQ- 1639
            |..:.|.:.                        :.|::...|.:.||.::..|   .|.|.:.: 
Mouse  1485 LVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVL---KKHNDDFEM 1546

  Fly  1640 -----KNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQN-ELEESRTLLEQADRGR 1698
                 .|..|:...||         |.:.|:.......:::..:.|:| :|.|.|.:|....   
Mouse  1547 TSFWLSNTCRFLHCLK---------QYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLS--- 1599

  Fly  1699 RQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAAR 1763
            .|..|:|....|.|    .|...:||   .||:|      .:..|.........|...:|||...
Mouse  1600 IQIYQQLIKIAEGL----LQPMIVSA---MLENE------SIQGLSGVRPTGYRKRSSSMVDGEN 1651

  Fly  1764 ------LADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAI-----QKLEQR 1817
                  :..::.:.......|....:.:.|..|:|...::....|.|...|.|.     .:|...
Mouse  1652 SYCLEAIVRQMNSFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYN 1716

  Fly  1818 VRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDK---LQQKIKTYKR 1879
            :.:||..|.|         |||.:|..               .:.|:.|:..   ||.|.||:  
Mouse  1717 ISQLEEWLRG---------KNLHQSGA---------------VQTMEPLIQAAQLLQLKKKTH-- 1755

  Fly  1880 QIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLA 1912
              |:||.|.:|       .:.|.......|.|.|||..::
Mouse  1756 --EDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVS 1793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/45 (27%)
MYSc 81..777 CDD:214580 281/727 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 272/696 (39%)
Myosin_tail_1 842..1897 CDD:279860 249/1183 (21%)
V_Alix_like 1557..1877 CDD:187408 67/366 (18%)
ATP-synt_B <1671..1771 CDD:304375 22/106 (21%)
TMPIT 1739..>1825 CDD:285135 16/96 (17%)
Myo5bXP_006525777.1 COG5022 11..>1268 CDD:227355 424/1386 (31%)
MYSc_Myo5 83..750 CDD:276831 272/696 (39%)
EnvC 1136..>1449 CDD:227278 95/420 (23%)
Myo5b_CBD 1475..1846 CDD:271261 72/375 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.