DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo5a

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_006510890.1 Gene:Myo5a / 17918 MGIID:105976 Length:1880 Species:Mus musculus


Alignment Length:2090 Identity:560/2090 - (26%)
Similarity:930/2090 - (44%) Gaps:445/2090 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SKPYDSKKSCWIPDEKEGY----LLGEIKATKGD-IVSVGLQGGETRDLKKD-----LLQQVNPP 83
            |:.|......||||.:|.:    ||.:.|  .|| ::.:.|:.|:..:.:.|     |....||.
Mouse     4 SELYTKFARVWIPDPEEVWKSAELLKDYK--PGDKVLLLHLEEGKDLEYRLDPKTGELPHLRNPD 66

  Fly    84 KYEKAEDMSNLTYLNDASVLHNLRQRYY-NKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKR 147
            ......|::.|:||::.:||||||.|:. :||||||.|:..||||||::.|:|.......|.|:.
Mouse    67 ILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQN 131

  Fly   148 RNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSK 212
            ..::.|||||:::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:
Mouse   132 MGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASE 189

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
            .::|::|:.:||::|:.|||||.||||||||||:|.|.|....::.||::.||||||:||:.|..
Mouse   190 ANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAE 254

  Fly   278 LERSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGF 340
            .||:||||||: .|..:|..|  .|...|...:|...| |...:..:|||:|.:.|.||..:||.
Mouse   255 EERNYHIFYQLCASAKLPEFK--MLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGI 317

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            ::..:..::||.|.::|:|.:.|..|..:........|.......|.|.|..|:...|...::..
Mouse   318 SESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCHRKLAT 382

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ..|...:..:..|.||:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|
Mouse   383 ATETYIKPISKLQATNARDALAKHIYAKLFNWIVDHVNQALHSAVKQHSFIGVLDIYGFETFEIN 447

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEE 535
            .|||.|||:.||||||.||.|:|.||||||.:|.|.||.||| .|.|.||:|||..:|||.:|:|
Mouse   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDE 511

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |...||.||.|:::||.||||.|.|.|:||:.....     |.|.|:|..|.|...|:||||||.
Mouse   512 ECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKA-----FIIKHFADKVEYQCEGFLEKNKDT 571

  Fly   601 LNDTVVDQFKKSQNKLLIEIFAD--------HAGQSG---------------GGEQAKGGRGKKG 642
            :.:..:...|.|:.|:|.|:|.|        .|..||               .|:.||  ..|| 
Mouse   572 VFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQTAK--EHKK- 633

  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707
                ||...::..|:.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||..
Mouse   634 ----TVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISA 694

  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLG 770
            .|||:|..|.:|..||:::..:  :.|..|:|.|  .::.|.| |.:|:|:.|.||:|||||.:.
Mouse   695 AGFPSRWTYQEFFSRYRVLMKQ--KDVLGDRKQTCKNVLEKLI-LDKDKYQFGKTKIFFRAGQVA 756

  Fly   771 QMEEFRDERL--------GKIMSWM---------------QAWARGYLSR---------KGFKKL 803
            .:|:.|.::|        ..|..|:               |.:.|||.:|         |....:
Mouse   757 YLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTI 821

  Fly   804 QE-------------QRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKA 855
            |:             :|.|..|:|..||.||....  :.|:.::.|.::...|:...:||...| 
Mouse   822 QKYWRMYVVRRRYKIRRAATIVIQSYLRGYLTRNR--YRKILREYKAVIIQKRVRGWLARTHYK- 883

  Fly   856 KKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNA----KLTAQKNDLEN 916
                    ..:|....|:....:::|::.  |..|..|..:::.|::.:.    |:...:..::.
Mouse   884 --------RTMKAIVYLQCCFRRMMAKRE--LKKLKIEARSVERYKKLHIGMENKIMQLQRKVDE 938

  Fly   917 QLRD---IQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
            |.:|   :.|:||..|...|          .|...|:.|:|.|:|    :|::......::.:|.
Mouse   939 QNKDYKCLMEKLTNLEGVYN----------SETEKLRNDVERLQL----SEEEAKVATGRVLSLQ 989

  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043
            :|||       ||.|:.       ::|..|.::.|::.:       |.:|..|:|..:|:.|..:
Mouse   990 EEIA-------KLRKDL-------EQTRSEKKSIEERAD-------KYKQETDQLVSNLKEENTL 1033

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRK-DKELSSITAKLEDEQVVVLKHQRQI 1107
               :::.|..:  :.::.::|        ||:.:|::|| .:|...:...|.||:   |::|..:
Mouse  1034 ---LKQEKETL--NHRIVEQA--------KEMTETMERKLVEETKQLELDLNDER---LRYQNLL 1082

  Fly  1108 KE---LQARIEELEEEVEAERQARAKAEKQRADLAR--------------ELEELGERLEEAGGA 1155
            .|   |:.|.::|:||:...... .|...:|.|...              |.|::..|.||   .
Mouse  1083 NEFSRLEERYDDLKEEMTLMLNV-PKPGHKRTDSTHSSNESEYTFSSEFAETEDIAPRTEE---P 1143

  Fly  1156 TSAQIELN-------KKREAELSKLRRDLEEANIQHESTLANLRKKHNDAV----AEMAEQVDQL 1209
            ...::.|:       :||..||.:.::.:::...:.|..:...:.|..:..    ||:..:..:.
Mouse  1144 IEKKVPLDMSLFLKLQKRVTELEQEKQLMQDELDRKEEQVFRSKAKEEERPQIRGAELEYESLKR 1208

  Fly  1210 NKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIA------KQLQHTLNEVQSKLDETNRT 1268
            .:|:::.:|.|||    ||:||..:    :||:|.|..|      :.|...|..|..:|      
Mouse  1209 QELESENKKLKNE----LNELRKAL----SEKSAPEVTAPGAPAYRVLMEQLTSVSEEL------ 1259

  Fly  1269 LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFR 1333
                |..|:::.|..|.|:.|.|..:.:..:  ......|..|||.:::.|:....:|.:..|..
Mouse  1260 ----DVRKEEVLILRSQLVSQKEAIQPKDDK--NTMTDSTILLEDVQKMKDKGEIAQAYIGLKET 1318

  Fly  1334 NLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAE 1398
            |....:|                   ..:.|.:.::| ..||.        |::|.|.|:::|..
Mouse  1319 NRSSTMD-------------------YQELNEDGELW-MVYEG--------LKQANRLLESQLQS 1355

  Fly  1399 AEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL- 1462
            .:.:.|:          ..:.|..|::.|:.|.:|                    :.:|...:| 
Mouse  1356 QKRSHEN----------EAEALRGEIQSLKEENNR--------------------QQQLLAQNLQ 1390

  Fly  1463 ---AAELDAS-QKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIH 1523
               .|.::|| |.|....:.|....:..|.:..::.::.|   .:|...:.||::|:.:..:.:.
Mouse  1391 LPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYR---ISLYKRMIDLMEQLEKQDKTVR 1452

  Fly  1524 EIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR--RIQEKEEEFENTR 1586
            :::|..|....:..||:..         |.||      :...|:..|..|  .|..||::|:...
Mouse  1453 KLKKQLKVFAKKIGELEVG---------QMEN------ISPGQIIDEPIRPVNIPRKEKDFQGML 1502

  Fly  1587 KNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKD 1651
            :..:.....:..:|..|.|.:..|:.:...|.|.|  |.:.:.||:..| :.||........:..
Mouse  1503 EYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYI--LFMCVRHADYLN-DDQKVRSLLTSTINS 1564

  Fly  1652 IQTALEE----------------------EQRARDDAREQLGISERRANALQN-ELEESRTLLEQ 1693
            |:..|::                      :|.:.::...:...|.:..:.|.| :|.|.|.:|..
Mouse  1565 IKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSD 1629

  Fly  1694 ADRGRRQAEQELADA---------------HEQLNEVSA--------QNASIS-AAKRKLESELQ 1734
            .   ..|..|:|...               ||.:..||.        :.:||: .....|:|.|:
Mouse  1630 L---AIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILR 1691

  Fly  1735 TLHSDLDELLNEAKNSE--EKAKKAM---VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQV 1794
            .|:|....:.....:.|  ::..|.|   |.|..|.:.|            |||.:....|.:|:
Mouse  1692 QLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLL------------LRKDMCSWSKGMQI 1744

  Fly  1795 RLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKN 1859
            |.:             :.:||:.:|:                |||..|..:              
Mouse  1745 RYN-------------VSQLEEWLRD----------------KNLMNSGAK-------------- 1766

  Fly  1860 HERMQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLAEQAIS 1917
             |.::.|: :..|.::..|:..::||.|.::       .:.|.......:.|.|||..::.....
Mouse  1767 -ETLEPLI-QAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTI 1829

  Fly  1918 KFRAKGRAGS 1927
            :.|.:.|..|
Mouse  1830 QMRLRDRKDS 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 12/46 (26%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 285/692 (41%)
Myosin_tail_1 842..1922 CDD:460256 225/1187 (19%)
Myo5aXP_006510890.1 COG5022 7..1448 CDD:227355 473/1616 (29%)
MYSc_Myo5 83..751 CDD:276831 285/692 (41%)
Myo5a_CBD 1506..1880 CDD:271262 72/397 (18%)

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