Protein Alignment Mhc and Myo1b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_006495827.1
• Gene: Myo1b / 17912
• MGIID: 107752
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1143
• Identity: 343/1143 - (30%)
• Similarity: 536/1143 - (46%)
• Gaps: 181/1143 - (15%)

  Fly    90 DMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPH 154
            ||..|..||:.:.:.||::|:.:..||||.|...:::|||:..|:|:....:.||.:...|:.||
Mouse    19 DMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPH 83

  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSKGSLEDQ 218
            |||:||.||..:.....:|.:||||||||||||.:|.|::|.|.| |...:.::       :::|
Mouse    84 IFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQ-------VKEQ 141

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            ::|:|||||||||||||||||||||||::.|.|...|...|..|..|||||:||:.|...||::|
Mouse   142 LLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFH 206

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            :|||::||:...:.....|..:...|:.:|.....|..:|||..|.....|..|:||...|.|.|
Mouse   207 VFYQLLSGASEELLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAV 271

  Fly   349 YRITAAVMHMGGMKFKQRGR----EEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEF 409
            ..:.|||:.:|.::||...|    :|...:| :.|...:.:|...|...|.:......::...|.
Mouse   272 LEVVAAVLKLGNIEFKPESRVNGLDESKIKD-KNELKEICELTSIDQVVLERAFSFRTVEAKQEK 335

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK-RQHFIGVLDIAGFEIFEY--NG 471
            |:...||.|...:..||.|.::.|||.|||.:.||::..|.| |:..:|||||.||||||.  |.
Mouse   336 VSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFENADNS 400

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEE 535
            |||..||:.||||||.|.......|||||.||.||||.||:..:..:| |||| ...|||::|:|
Mouse   401 FEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIIC-DLIENNTNGILAMLDE 464

  Fly   536 ESMFP-KATDQTFSEKLTN---THLGKSAPFQKPKPPKPGQQAAH--FAIAHYAGCVSYNITGWL 594
            |.:.| ..||:||.|||..   ||....:...|...........|  |.|.||||.|.|.:.|::
Mouse   465 ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFV 529

  Fly   595 EKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSL 659
            :||.|.|...:.....|:.:.|:..:|.:       |..||....:.    .|..|.:|..:.:|
Mouse   530 DKNNDLLYRDLSQAMWKAGHSLIKSLFPE-------GNPAKVNLKRP----PTAGSQFKASVATL 583

  Fly   660 MTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYK 724
            |..|::..|:::|||.||:.|...:.:..||.||:...|:||.:|:.|.|:..|..|.....|||
Mouse   584 MRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYK 648

  Fly   725 IMCPKL---LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQMEEFRDERLGKIMS 785
            ::|.:.   .:|  ..:...|::...:::|.:::..|.:|:|.| ...|.|:|:.|.:||..:.:
Mouse   649 MLCKQTWPHWKG--PARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLAT 711

  Fly   786 WMQAWARGYLSRKGFKKLQEQRVALKVVQRNL---RKYLQ-----------LRTWPWYKL----- 831
            .:|...||:..|..|..::..:|.:....|..   ::|.|           :|.|...|:
Mouse   712 LIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELK 776

  Fly   832 ---------------WQKVKPLLNVSRIED----------------------EIARLEEKAKKAE 859
                           |...:....:.|::|                      |:.||:|:|::.
Mouse   777 HQKRCKEAATTIAAYWHGTQARRELRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRK- 840

  Fly   860 ELHAAEV--------KVRKE-----------------LEALNAKLLAEKTALLDSLS-------G 892
              ||..|        |||:|                 |:.:..|.|.|....:.|||       .
Mouse   841 --HAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPS 903

  Fly   893 EKGALQDYQERNAK----LTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDI 953
            ......|...:..|    |...|. ..:|..|.|:.:.:|:...::||:.||.......|.....
Mouse   904 RPYLFLDSTHKELKRIFHLWRCKK-YRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQG 967

  Fly   954 EDLELNVQKAEQDKATKDHQIRNLNDEIAHQ---DELINKLNKEKKMQGETNQK----TGEELQA 1011
            ..||:|          |:.:.:.|.|.|..:   .|::||:|   :..|::..:    |...|..
Mouse   968 AYLEIN----------KNPKYKKLKDAIEEKIIIAEVVNKIN---RANGKSTSRIFLLTNNNLLL 1019

  Fly  1012 AEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD-------VEKSKRKVEGDLKLTQEAVADLE 1069
            |:.|   ..::|:::     .|.|..:.....:.|       .|.|:...:||...:.:.:.::.
Mouse  1020 ADQK---SGQIKSEV-----PLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMA 1076

  Fly  1070 RN--KKELEQTIQRKDKELSSITAKLEDEQVVVLKHQR 1105
            ..  :..|.||.|:.:.|:|       ||.:|..:..:
Mouse  1077 TKLYRTTLSQTKQKLNIEIS-------DEFLVQFRQDK 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	251/682 (37%)
		Myosin_tail_1	842..1922	CDD:460256	67/338 (20%)
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	251/682 (37%)
		IQ	751..773	CDD:197470	4/21 (19%)
		Myosin_TH1	943..1120	CDD:461801	38/193 (20%)