DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhc and Myo15

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_034992.2	Gene:	Myo15 / 17910	MGIID:	1261811	Length:	3511	Species:	Mus musculus

Alignment Length:	843	Identity:	278/843 - (32%)
Similarity:	444/843 - (52%)	Gaps:	48/843 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP 133
            :|::.|.:..:.:  :.:.:|||..:..|....||.||:.|:...|||||.|...|::|||:.:.
Mouse  1191 IRNLPSMRSREQH--REDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFA 1253

  Fly   134 VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT 198
            :|.....:.|.|:...|.|||:|||::.|:..||....||.::|:||||:||||.||.::...|.
Mouse  1254 IYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAA 1318

  Fly   199 VGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIE 263
            :...:...:..|        :::..|:|||||||||||||||||||||:.| |...|.:.||...
Mouse  1319 MNQRRDVMQQIK--------ILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITS 1374

  Fly   264 TYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEF 328
            .|||||:|::.|...||:|||||::::|....::....|.:....|::...|...:|...||::|
Mouse  1375 QYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDF 1439

  Fly   329 SLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE--------EGGRVSK 385
            .....|.::||||.::::.::||.|:::|:|.:.|      |:.|.|.:|        |...|::
Mouse  1440 RRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYF------EKHETDAQEVASVVSAREIQAVAE 1498

  Fly   386 LFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQ 450
            |.......|.|.:.....:...|.:.....|:...::..|:.|.::..||.||:.:.|..:..:|
Mouse  1499 LLQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQ 1563

  Fly   451 KRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMD 515
            .... |.:|||.|||...:|.|||||||:.||.||..||..:|..|||||.||.:||..|.|. |
Mouse  1564 DTLS-IAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFA-D 1626

  Fly   516 LLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAI 579
            ...||:||. ||.|||.||:::..||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.|
Mouse  1627 NQPCINLISLKPYGILRILDDQCCFPQATDHTFLQK-CHYHHGANPLYSKPKMPLP-----EFTI 1685

  Fly   580 AHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGG 644
            .||||.|:|.:..:|:||.|.:...|:|.|..|:.:::..:|:.||.|:......|.....:...
Mouse  1686 KHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYK 1750

  Fly   645 FATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKG 709
            ..||::.:::.|..|:..:....|.||||:.||..|:||:.:..::|.||..:||||.:||.::|
Mouse  1751 AHTVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEG 1815

  Fly   710 FPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEE 774
            ||.|:.:..|..||:.:....|...........::.:...:..|.||:|.:|:|.:..:...:|.
Mouse  1816 FPVRLPFQVFIDRYRCLVALKLNVPADGDMCVSLLSRLCTVTPDMYRVGISKLFLKEHLHQLLES 1880

  Fly   775 FRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL---RKYLQLRTWPWYKLWQKVK 836
            .|:....:....:|.:.||:..::.|:.|:.:.:.|:...|..   ::|.|:|. ...|....|.
Mouse  1881 MRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQ-SLLKFRSLVH 1944

  Fly   837 PLLNVSRIEDEIARLEEKAKKA-----EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK 894
            ..:|..|.....|....:|::|     |||...||...:.||     :.||...||.:.:|.|
Mouse  1945 TYVNRRRYLKLRAEQRRRAQEAWLREQEELSKREVVPVRHLE-----VPAEVAGLLQAAAGLK 2002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	1/3 (33%)
		MYSc	81..777	CDD:214580	245/704 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	240/673 (36%)
		Myosin_tail_1	842..1897	CDD:279860	17/58 (29%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo15	NP_034992.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..1030
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1135
		MYSc	1201..1883	CDD:214580	245/706 (35%)
		MYSc_Myo15	1220..1871	CDD:276838	240/673 (36%)
		Actin-binding. /evidence=ECO:0000255	1776..1783		4/6 (67%)
		FliJ	1870..1960	CDD:280262	17/90 (19%)
		Neck or regulatory domain	1872..2013		32/137 (23%)
		Tail	2014..3511
		MyTH4	2049..2195	CDD:214535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2330..2359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2392..2425
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2460..2509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2565..2584
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2629..2648
		SH3	2852..2931	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2964..2984
		MyTH4	3031..3185	CDD:214535
		B41	3195..3400	CDD:214604
		FERM_B-lobe	3290..3390	CDD:271216
		FERM_C_MyoXV	3396..3497	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000