DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo15a

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_034992.2 Gene:Myo15a / 17910 MGIID:1261811 Length:3511 Species:Mus musculus


Alignment Length:952 Identity:298/952 - (31%)
Similarity:467/952 - (49%) Gaps:121/952 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PKPVANQE--DEDPTPYLFVSLEQRRIDQSKPYDSKKSC-------WIPDE------------KE 45
            |.||...|  |:||        ||....|        :|       |.|.:            .:
Mouse  1113 PAPVQPPEHPDQDP--------EQGPAPQ--------ACSLRWPRLWPPTDAHCLWSRIRTYSSQ 1161

  Fly    46 GYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQVNPPKYEK---------------------AE 89
            .:|.|              .||   |..|.|.::..|..::.                     .|
Mouse  1162 SHLRG--------------HGG---DCHKSLWKKTRPQSWQNKMHSIRNLPSMRSREQHREDGVE 1209

  Fly    90 DMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPH 154
            ||:.|..|.:.:||.||:.|:...|||||.|...|::|||:.:.:|.....:.|.|:...|.|||
Mouse  1210 DMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPPH 1274

  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219
            :|||::.|:..||....||.::|:||||:||||.||.::...|.:...:...:..|        :
Mouse  1275 LFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAAMNQRRDVMQQIK--------I 1331

  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHI 284
            ::..|:|||||||||||||||||||||:.| |...|.:.||....|||||:|::.|...||:|||
Mouse  1332 LEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQAKNERNYHI 1395

  Fly   285 FYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVY 349
            ||::::|....::....|.:....|::...|...:|...||::|.....|.::||||.::::.::
Mouse  1396 FYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIF 1460

  Fly   350 RITAAVMHMGGMKFKQRGREEQAEQDGEE--------EGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            ||.|:::|:|.:.|      |:.|.|.:|        |...|::|.......|.|.:.....:..
Mouse  1461 RILASILHLGNVYF------EKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVTETI 1519

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            .|.:.....|:...::..|:.|.::..||.||:.:.|..:..:|.... |.:|||.|||...:|.
Mouse  1520 REKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTLS-IAILDIYGFEDLSFNS 1583

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEE 535
            |||||||:.||.||..||..:|..|||||.||.::|..|.|. |.|.||:||. ||.|||.||::
Mouse  1584 FEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFA-DNQPCINLISLKPYGILRILDD 1647

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            :..||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.|.||||.|:|.:..:|:||.|.
Mouse  1648 QCCFPQATDHTFLQK-CHYHHGANPLYSKPKMPLP-----EFTIKHYAGKVTYQVHKFLDKNHDQ 1706

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            :...|:|.|..|:.:::..:|:.||.|:......|.....:.....||::.:::.|..|:..:..
Mouse  1707 VRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMER 1771

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            ..|.||||:.||..|:||:.:..::|.||..:||||.:||.::|||.|:.:..|..||:.:....
Mouse  1772 CNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALK 1836

  Fly   731 LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYL 795
            |...........::.:...:..|.||:|.:|:|.:..:...:|..|:....:....:|.:.||:.
Mouse  1837 LNVPADGDMCVSLLSRLCTVTPDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRYLRGFF 1901

  Fly   796 SRKGFKKLQEQRVALKVVQRNL---RKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK 857
            .::.|:.|:.:.:.|:...|..   ::|.|:|. ...|....|...:|..|.....|....:|::
Mouse  1902 IQRHFRSLRRKIILLQSRARGFLARQRYQQMRQ-SLLKFRSLVHTYVNRRRYLKLRAEQRRRAQE 1965

  Fly   858 A-----EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK 894
            |     |||...||...:.||     :.||...||.:.:|.|
Mouse  1966 AWLREQEELSKREVVPVRHLE-----VPAEVAGLLQAAAGLK 2002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 8/60 (13%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 240/673 (36%)
Myosin_tail_1 842..1922 CDD:460256 17/58 (29%)
Myo15aNP_034992.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
PRK10263 <310..>559 CDD:236669
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..690
PHA03247 <673..1147 CDD:223021 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1135 10/37 (27%)
MYSc_Myo15 1220..1871 CDD:276838 240/673 (36%)
Actin-binding. /evidence=ECO:0000255 1776..1783 4/6 (67%)
Neck or regulatory domain 1872..2013 32/137 (23%)
IQ 1909..1930 CDD:197470 3/20 (15%)
Tail 2014..3511
MyTH4 2049..2195 CDD:214535
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2330..2359
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2392..2425
PHA03247 <2415..2653 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2460..2509
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2565..2584
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2648
SH3 2852..2931 CDD:473055
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2964..2984
MyTH4 3031..3185 CDD:214535
FERM_M 3280..3400 CDD:459788
FERM_C_MyoXV 3396..3497 CDD:270022
Blue background indicates that the domain is not in the aligned region.

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