DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh6

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_006518740.1	Gene:	Myh6 / 17888	MGIID:	97255	Length:	1939	Species:	Mus musculus

Alignment Length:	1921	Identity:	1088/1921 - (56%)
Similarity:	1443/1921 - (75%)	Gaps:	20/1921 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKV 80
            ||..|.::|...|::|:|.:..|::||:||.|:..::.:.:|..|:...:.|:...||.::|.:.
Mouse    15 YLRKSEKERLEAQTRPFDIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTIKEDQVMQQ 79

  Fly    81 NPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRG 145
            |||||:||||||.:|.|:.|.||:||::||.|.:||||||||||.:||||..|||.......|||
Mouse    80 NPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRG 144

  Fly   146 KRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKTD 206
            |:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||::.|    |||.:
Mouse   145 KKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKEN 209

  Fly   207 EAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKAR 271
            ..| :||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:|
Mouse   210 PNA-NKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSR 273

  Fly   272 VISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFD 336
            ||.|...||:|||||||:|...|.:.|:.|:|:|.|||..||||:|:||||||:||...||.|||
Mouse   274 VIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338

  Fly   337 ILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKP 401
            :|.||.:||..||::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..|
Mouse   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHP 403

  Fly   402 RIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEI 466
            |:|||||:||:|::||||..|||||.|.|::::|.|:|.:.|.||:|:|.||:||||||||||||
Mouse   404 RVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEI 468

  Fly   467 FEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILS 531
            |::|.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:|
Mouse   469 FDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMS 533

  Fly   532 ILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEK 596
            |||||.|||||:|.||..||.:.|||||..||||:..| |:|.|||::.||||.|.|||.|||||
Mouse   534 ILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVK-GKQEAHFSLVHYAGTVDYNIMGWLEK 597

  Fly   597 NKDPLNDTVVDQFKKSQNKLLIEIFADHA----GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLN 657
            ||||||:|||..::||..||:..:|:.:|    |.||.|   |||: |||..|.|||:.::|.||
Mouse   598 NKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKG---KGGK-KKGSSFQTVSALHRENLN 658

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            .|||.|::|.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.|
Mouse   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 723

  Fly   723 YKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIM 784
            |:|:.|..:   |.:: .:|..|.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|:
Mouse   724 YRILNPAAIPEGQFID-SRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRII 787

  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849
            :.:||.|||.|.|..|||:.|:|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|
Mouse   788 TRIQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMA 852

  Fly   850 RLEEKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
            .::|:..:.:: |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|..
Mouse   853 NMKEEFGRVKDALEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
            ||.:::::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.
Mouse   917 LEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 981

  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043
            :|:|..||:|.||.||||...|.:|:..::|||.|||:|.|.|.|.||||.:|:||.|||:||||
Mouse   982 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKV 1046

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108
            |.|:|::|||:|||||||||::.|||.:|.:||:.:::|:.::|...:|:||||.:.|:.|:::|
Mouse  1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLK 1111

  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
            |.||||||||||:||||.||||.||.|:||:|||||:.|||||||||||.|||:|||||||..|:
Mouse  1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1176

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238
            |||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|.
Mouse  1177 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1241

  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI 1303
            ..||..||:::.|:...||.:.||:|..|:||||...:.||..||.:|.|||||.|:.:|||::.
Mouse  1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRG 1306

  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQ 1368
            |:|.|.|:||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|..
Mouse  1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVA 1371

  Fly  1369 VWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDR 1433
            .||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|
Mouse  1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436

  Fly  1434 ANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVR 1498
            :||.|.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..:
Mouse  1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501

  Fly  1499 RENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLE 1563
            ||||||.:|:.||.:|:||||:|:||:||.||:||.||.|||:|||||||:||.||.|:||||||
Mouse  1502 RENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566

  Fly  1564 LSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIAL 1628
            .:|::.||:|::.||:||.|..::||.|.:||:|.||:||.:.:.||||:|||:|.|:||:||.|
Mouse  1567 FNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1631

  Fly  1629 DHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQ 1693
            ..||:..:||||::|..|..|||.|..|::...|.||.:|.:.|.|||.|.||.||||.|.::||
Mouse  1632 SQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696

  Fly  1694 ADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAM 1758
            .:|.|:.|||||.:..|::..:.:||.|:...|:|:||:|..|.::::|.:.|.:|:|||||||:
Mouse  1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAI 1761

  Fly  1759 VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELEN 1823
            .|||.:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.|||||||
Mouse  1762 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 1826

  Fly  1824 ELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIA 1888
            ||:.||:|:|::.|.:||||||:|||::|:|||:||..|:||||||||.|:|.||||.|||||.|
Mouse  1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQA 1891

  Fly  1889 ALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ..||:||||.|.||:|||||||:||..::|.|||.|
Mouse  1892 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	452/706 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	432/675 (64%)
		Myosin_tail_1	842..1897	CDD:279860	564/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	47/99 (47%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
Myh6	XP_006518740.1	Myosin_N	34..72	CDD:367160	9/37 (24%)
		MYSc_class_II	99..768	CDD:276951	432/675 (64%)
		Myosin_tail_1	848..1925	CDD:366712	580/1077 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1105	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2092	1.000	Inparanoid score	I42
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm43784
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860