Protein Alignment Mhc and Myh8

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_036012291.1
• Gene: Myh8 / 17885
• MGIID: 1339712
• Length: 1966
• Species: Mus musculus
• Alignment Length: 1949
• Identity: 1066/1949 - (54%)
• Similarity: 1426/1949 - (73%)
• Gaps: 41/1949 - (2%)

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDL 76
            :..|||..|.::|...|:||:|:|.|.::.:.||.|:...|::..|..|:|..:.|.|..:|:|.
Mouse    14 EAAPYLRKSEKERIEAQNKPFDAKTSVFVAEPKESYVKSVIQSKDGGKVTVKTESGATLTVKEDQ 78

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:|||||:|.|||:.:|:|::..||:||::||...:||||||||||.:||||..|||......
Mouse    79 VFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 143

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Mouse   144 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 208

  Fly   205 TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEK 269
            .:|:.|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||
Mouse   209 KEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEK 273

  Fly   270 ARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQA 334
            :||..|...||||||||||.|...|.:.::.|:|.|.|||..||||::||.||||.||...||.|
Mouse   274 SRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSA 338

  Fly   335 FDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLL 399
            .|||||:.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|.|.
Mouse   339 IDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQCLNSADLLKALC 403

  Fly   400 KPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGF 464
            .||:|||||:||:|:.||||.|::|||.|.|::::|.|:|.:.|:.|||:|.||:||||||||||
Mouse   404 YPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGF 468

  Fly   465 EIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGI 529
            |||::|..||||||||||||||||||||||||||||::||||||||||||||..||:|||||:||
Mouse   469 EIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGI 533

  Fly   530 LSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWL 594
            .||||||.|||||||.:|..||.:.|||||..||||||.| |:..|||::.||||.|.|||||||
Mouse   534 FSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPTK-GKAEAHFSLVHYAGTVDYNITGWL 597

  Fly   595 EKNKDPLNDTVVDQFKKSQNKLLIEIFADHA-GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNS 658
            :|||||||||||..::||..|.|..:|:.:| .::.||  ||.|..|||..|.|||:.::|.||.
Mouse   598 DKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADGG--AKKGAKKKGSSFQTVSALFRENLNK 660

  Fly   659 LMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRY 723
            |||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|||.||
Mouse   661 LMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRY 725

  Fly   724 KIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMS 785
            |::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|.:|::
Mouse   726 KVLNASAIPEGQFID-SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIIT 789

  Fly   786 WMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR 850
            ..||..||||.|..::|:..:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.
Mouse   790 RTQAVCRGYLMRVEYQKMLLRRESIFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMAT 854

  Fly   851 LEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDL 914
            ::|:.:|. :||..:|.| |||||.....||.||..|...:..|..:|.|.:||..:|...|..|
Mouse   855 MKEEFQKTKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQL 918

  Fly   915 ENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLND 979
            |.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:
Mouse   919 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 983

  Fly   980 EIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVR 1044
            |:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|
Mouse   984 EMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLR 1048

  Fly  1045 GDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKE 1109
            .|:|::|||:||||||.||:..|:|.:|::|::.:::|:.|:|::.:|:||||.|.::.|::|||
Mouse  1049 MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEISNLISKIEDEQAVEIQLQKKIKE 1113

  Fly  1110 LQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLR 1174
            |||||||||||:||||.:||||||||:||:|||||:.|||||||||||||:|:|||||.|..|||
Mouse  1114 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEMNKKRETEFQKLR 1178

  Fly  1175 RDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITN 1239
            ||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:..:.|..
Mouse  1179 RDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAK 1243

  Fly  1240 EKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIK 1304
            .|...||:.:.|:..::|::||.:|..|.:|:..|.:.:|..|..:..|||:|.::.|||||:.|
Mouse  1244 AKGNLEKMCRTLEDQVSELKSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK 1308

  Fly  1305 ISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQV 1369
            .:.|.|:|:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|...
Mouse  1309 QASTQQIEELKRQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373

  Fly  1370 WRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRA 1434
            ||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.::|:|.
Mouse  1374 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1438

  Fly  1435 NAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRR 1499
            ||...|.:|||:.|||::.||:.|.::..|||::.|||.|..|||||::|.||||..:.||.:||
Mouse  1439 NAACAALDKKQRNFDKVLSEWRQKYEETQAELESCQKESRTLSTELFKVKNAYEESLDHLETLRR 1503

  Fly  1500 ENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLEL 1564
            |||||..|:.||.:||.|||::|||:||.:|::|.||.|:|||||||||:||.||.|:||.||||
Mouse  1504 ENKNLQQEISDLTEQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLEL 1568

  Fly  1565 SQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALD 1629
            :||:.||||:|.||:||.:..::||.|.:::||::|:||.:.:.:|||:|||:|.|:||:||.|:
Mouse  1569 NQVKSEIDRKIAEKDEEIDQLKRNHVRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLN 1633

  Fly  1630 HANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQA 1694
            |||:..||:.:|.:..|..|||.|..|::..|.::|.:|||.|.|||||.||.|:||.|..|||.
Mouse  1634 HANRLAAESLRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELRATLEQT 1698

  Fly  1695 DRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMV 1759
            :|.|:.|||||.||.|::..:..||.|:...|:|||:::..|.|:::|::.|::|:|||||||:.
Mouse  1699 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAIT 1763

  Fly  1760 D-----------------------------AARLADELRAEQDHAQTQEKLRKALEQQIKELQVR 1795
            |                             ||.:|:||:.|||.:...|:::|.:||.:|:||.|
Mouse  1764 DVSTTHITLPTPVLPATTRAYFCLDLFASQAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHR 1828

  Fly  1796 LDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNH 1860
            |||||..|||||||.|||||.||||||.|::.||:|:|:|.|.|||.|||||||::|:||||||.
Mouse  1829 LDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1893

  Fly  1861 ERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            .|:||||||||.|:|:||||.|||||.:..|||||||.|.||||||||||:||..::|.|.|.|
Mouse  1894 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	13/41 (32%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	422/670 (63%)
		Myosin_tail_1	842..1922	CDD:460256	575/1109 (52%)
Myh8	XP_036012291.1	Myosin_N	35..79	CDD:460670	14/43 (33%)
		Motor_domain	102..769	CDD:473979	422/670 (63%)
		Myosin_tail_1	849..1955	CDD:460256	575/1106 (52%)