Protein Alignment Mhc and Myh4

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_034985.2
• Gene: Myh4 / 17884
• MGIID: 1339713
• Length: 1939
• Species: Mus musculus
• Alignment Length: 1922
• Identity: 1065/1922 - (55%)
• Similarity: 1431/1922 - (74%)
• Gaps: 13/1922 - (0%)

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDL 76
            :..|||..|.::|...|:||:|:|.|.::.|.||.|:...:::.:|..|:...:||.|..:|.|.
Mouse    12 EAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAKTEGGATVTVKDDQ 76

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:|||||:|.|||:.:|:|::.:||:||::||...:||||||||||.:||||..|||......
Mouse    77 VFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Mouse   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   205 TDEA--AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:||  .|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Mouse   207 KEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||||...|.:.::.|:|.|.||:..||||::||.||||.||...||
Mouse   272 EKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.|||||:..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|.
Mouse   337 TAVDILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.||||.||:|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
Mouse   402 LCYPRVKVGNEYVTKGQTVQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM 527
            |||||::|..||||||||||||||||||||||||||||::|||:|.||||||||..||:||||||
Mouse   467 GFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...|||||..||||||.| |:..|||::.||||.|.|||.|
Mouse   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAK-GKAEAHFSLVHYAGTVDYNIIG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFA-DHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656
            ||:|||||||:|||..::||..|.|..:|: ..|.::.||...|||: |||..|.|||:.::|.|
Mouse   596 WLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGGGKKGGK-KKGSSFQTVSALFRENL 659

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            |.|||.|:||.||||||:||||.|.||.::..||:|||.||||||||||||||||:|::|.|||.
Mouse   660 NKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQ 724

  Fly   722 RYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKI 783
            |||::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|.::
Mouse   725 RYKVLNASAIPEGQFID-SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQL 788

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI 848
            ::..||..||||.|..|||:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:
Mouse   789 ITRTQAVCRGYLMRVEFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEM 853

  Fly   849 ARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKN 912
            |.::|..:|| |:|..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|.
Mouse   854 ANMKEDFEKAKEDLAKSEAK-RKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKI 917

  Fly   913 DLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL 977
            .||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||
Mouse   918 QLEAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982

  Fly   978 NDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKK 1042
            .:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||
Mouse   983 TEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKK 1047

  Fly  1043 VRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQI 1107
            :|.|:|::|||:||||||.||:..|:|.:|::|::.:::|:.|:|::.:|:||||.:.::.|::|
Mouse  1048 LRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKI 1112

  Fly  1108 KELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSK 1172
            |||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||..|
Mouse  1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1177

  Fly  1173 LRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHI 1237
            :|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.::.:
Mouse  1178 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETV 1242

  Fly  1238 TNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSK 1302
            :..|...||:.:.|:..|:||::|.:|..|.:|:....|.:|..|:.:..|||:|.::.|||||:
Mouse  1243 SKAKGNLEKMCRTLEDQLSEVKTKEEEQQRLINELSTQKARLHTESGEFSRQLDEKDAMVSQLSR 1307

  Fly  1303 IKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA 1367
            .|.:.|.|:|:.||..:|||:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|.
Mouse  1308 GKQAFTQQIEELKRQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEV 1372

  Fly  1368 QVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVD 1432
            ..||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..||||||||..|||||.::|:
Mouse  1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE 1437

  Fly  1433 RANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAV 1497
            |:||...|.:|||:.|||::.|||.|.::..|||:|||||.|:.|||||::|.||||..:|||.:
Mouse  1438 RSNAACAALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETL 1502

  Fly  1498 RRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQL 1562
            :||||||..|:.||.:||.|||::|||:||.:|:::.||.||||:||||||:||.||.|:||.||
Mouse  1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQL 1567

  Fly  1563 ELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIA 1627
            ||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|||:|||:|.|:||:||.
Mouse  1568 ELNQVKSEIDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632

  Fly  1628 LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLE 1692
            |:|||:..|||.:|::..|..|||.|..|::..|.:||.:|||.:.|||||.:|.|:||.|..||
Mouse  1633 LNHANRQAAEAIRNLRNTQGMLKDTQLHLDDALRGQDDLKEQLAMVERRANLMQAEIEELRASLE 1697

  Fly  1693 QADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKA 1757
            |.:|.||.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:|||||||
Mouse  1698 QTERSRRVAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762

  Fly  1758 MVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELE 1822
            :.|||.:|:||:.|||.:...|:::|.:||.:|:||.||||||..|||||||.|||||.||||||
Mouse  1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827

  Fly  1823 NELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEI 1887
            ||::.||:|:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|.||||.|||||.
Mouse  1828 NEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQ 1892

  Fly  1888 AALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            :.:|||||||.|.||||||||||:||..::|.|.|.|
Mouse  1893 SNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSR 1929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	13/41 (32%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	418/672 (62%)
		Myosin_tail_1	842..1922	CDD:460256	576/1080 (53%)
Myh4	NP_034985.2	Myosin_N	33..77	CDD:460670	14/43 (33%)
		MYSc_Myh4	100..770	CDD:276879	418/672 (62%)
		Actin-binding. /evidence=ECO:0000250	659..681		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	761..775		8/13 (62%)
		Myosin_tail_1	850..1927	CDD:460256	576/1077 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1147		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1153..1172		17/18 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1276..1299		7/22 (32%)