Protein Alignment Mhc and Myh3

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001093105.1
• Gene: Myh3 / 17883
• MGIID: 1339709
• Length: 1940
• Species: Mus musculus
• Alignment Length: 1918
• Identity: 1073/1918 - (55%)
• Similarity: 1430/1918 - (74%)
• Gaps: 14/1918 - (0%)

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQ 79
            |:|..|.::|...|::|:|:|..|::.|.||.|:.|:||:::...|:|..:...|..:|.:.:..
Mouse    15 PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYVKGKIKSSQDGKVTVETEDSRTLVVKPEDVYA 79

  Fly    80 VNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            :||||::|.|||:.||:||:.:||:||:.||.:.:||||||||||.:||||..|||.......||
Mouse    80 MNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYR 144

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205
            ||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:.|    :||.
Mouse   145 GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKK 209

  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270
            |  :|.||:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||:
Mouse   210 D--SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKS 272

  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335
            ||..|...||||||||||:|...|.:.::.|:|.|.|||..:|||::.|||||||||...||.|.
Mouse   273 RVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337

  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400
            ||||||.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::::|.|.|..
Mouse   338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCF 402

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            ||:|||||:||:|:.|.||.:::.||.|.|:::||.|:|.:.|:.|||:..||||||||||||||
Mouse   403 PRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFE 467

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGIL 530
            |||||..||||||||||||||||||||||||||||::||||||||||||||..||:||||||||.
Mouse   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIF 532

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            ||||||.|||||||.:|..||.:.|||||..|||||..| |:..|||::.||||.|.|:::||||
Mouse   533 SILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK-GKAEAHFSLVHYAGTVDYSVSGWLE 596

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLM 660
            |||||||:|||..::||.|:||..::|..|.....|.:.|..: |||..|.|||:.::|.||.||
Mouse   597 KNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAK-KKGSSFQTVSALFRENLNKLM 660

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            :.||:|.|||||||||||.|.||.::..||:|||.||||||||||||||||||::|.|||.||::
Mouse   661 SNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRV 725

  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787
            :....:   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.|||||.|:::..
Mouse   726 LNASAIPEGQFID-SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRT 789

  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852
            ||..||:|.|..|:|:.::|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
Mouse   790 QAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK 854

  Fly   853 EKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
            |:.:|. :||..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|..||.
Mouse   855 EEFQKTKDELAKSEAK-RKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA 918

  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981
            :::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:
Mouse   919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEL 983

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
            |..||.|.||.:|||...|.:|:|.::|||.|||:|.|:|:|:||||.:|:||.|||:|||:|.|
Mouse   984 AGLDETIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVD 1048

  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQ 1111
            :|::|||:||||||.||::.|||.:|::|::.:::||.|.|.:.:|:||||.:.|:.|::|||||
Mouse  1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQ 1113

  Fly  1112 ARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRD 1176
            |||||||||:||||..|||.||||:|.|||||||.||||||||.||.|||||||||||..|||||
Mouse  1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178

  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241
            ||||.:|||:|:|.|||||.|:.||:|||:|.|.::|.|.||||:|:..:::||.:.|:.::..|
Mouse  1179 LEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVSKSK 1243

  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306
            |..|||.:.|:..|:|.:.|.:|..|:|::....|.:|..|..:|.|||||.||.|||||:.|.:
Mouse  1244 ANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308

  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371
            .|.|:|:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|...||
Mouse  1309 FTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373

  Fly  1372 SKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANA 1436
            :|||:|.:.|:|||||||:||..||.::||.:|::|.||..||||||||..|||||.::|:|||:
Mouse  1374 TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438

  Fly  1437 IANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501
            :|.|.:|||:.|||::.|||.|.::..|||:|:.||.|:.|||||:||.||||..:|||.|:|||
Mouse  1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKREN 1503

  Fly  1502 KNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ 1566
            |||..|:.||.:||.|.|::|||:||:||::|.||.::|.||||||||||.||.|:||.||||:|
Mouse  1504 KNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQ 1568

  Fly  1567 VRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHA 1631
            |:.||||:|.||:||.|..::|:||.:::||.:|:||.:.:.||:|:|||:|.|:||:||.|.||
Mouse  1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633

  Fly  1632 NKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADR 1696
            |:..||..|:::..|.||||.|..|::..|.::|.:|||.|.|||||.||.|:||.|..|||.:|
Mouse  1634 NRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTER 1698

  Fly  1697 GRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA 1761
            .|:.|||||.|::|::..:..||.|:...|:|||::|..|.|::::...:|:|:|||||||:.||
Mouse  1699 ARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDACRDARNAEEKAKKAITDA 1763

  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826
            |.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|:||||.||:
Mouse  1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALN 1891
            |||:|:.::.|.|||.|||||||::||||||||..|:||||||||.|:|:||||.|||:|.|..:
Mouse  1829 GEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893

  Fly  1892 LAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.||||||.||||||||||:||..::|.|||.|
Mouse  1894 LTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/41 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	418/671 (62%)
		Myosin_tail_1	842..1922	CDD:460256	585/1080 (54%)
Myh3	NP_001093105.1	Myosin_N	33..77	CDD:460670	14/43 (33%)
		MYSc_Myh3	100..767	CDD:276878	418/671 (62%)
		Actin-binding. /evidence=ECO:0000250	656..678		16/21 (76%)
		Actin-binding. /evidence=ECO:0000250	758..772		8/13 (62%)
		Myosin_tail_1	847..1924	CDD:460256	585/1077 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1289		7/28 (25%)