DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and Myh2

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:1925 Identity:1068/1925 - (55%)
Similarity:1428/1925 - (74%) Gaps:16/1925 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||..|.::|...|::|:|:|.|.::.:.||.::.|.|::.....|:|..:.|....:|.::
Mouse    12 EAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATLTVKEDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
Mouse    77 IFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Mouse   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   205 TDEA--AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:||  .|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Mouse   207 KEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||.|...|.:.::.|:|.|.|||..||||:::||||||.||...||
Mouse   272 EKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::|:|.|.
Mouse   337 SAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.|:||||::|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
Mouse   402 LCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM 527
            |||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||
Mouse   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...||||||.|||||..| |:..|||::.||||.|.|||||
Mouse   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVK-GKAEAHFSLIHYAGTVDYNITG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF-----ADHAGQSGGGEQAKGGRGKKGGGFATVSSAY 652
            ||:|||||||:|||..::||..|.|..:|     |:....|||.  ||.|..|||..|.|||:.:
Mouse   596 WLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGA--AKKGAKKKGSSFQTVSALF 658

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            :|.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.
Mouse   659 RENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYA 723

  Fly   718 DFKMRYKIM-CPKLLQGVEKD-KKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            |||.|||:: ...:.:|...| |||:|.::..||:...||:.|:|||||:||:||.:||.||::|
Mouse   724 DFKQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 788

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||:|:|..::|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|
Mouse   789 AQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETE 853

  Fly   846 DEIARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:|. ::|..:|.| |||||.....||.||..|...:..|...|.|.:||..:|..
Mouse   854 KEMATMKEEFQKTKDDLAKSEAK-RKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIK 917

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
Mouse   918 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 982

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
Mouse   983 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1047

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||::.|:|..|::|::.:::|:.|:|::.:|:||||.:.::.|
Mouse  1048 EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQ 1112

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
Mouse  1113 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1177

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.|
Mouse  1178 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1242

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.::..|...||:.:.|:..::|::||.:|..|.:||....:.:|..|:.:..|||:|.|:.|||
Mouse  1243 ETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQ 1307

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||
Mouse  1308 LSRGKQAFTQQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1372

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            :|...||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.|
Mouse  1373 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1437

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:..||||::|.||||..:||
Mouse  1438 DVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQL 1502

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
Mouse  1503 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1567

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
Mouse  1568 IQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEM 1632

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|:|:..|||.:|.:..|..|||.|..|::..|.::|.:|||.:.|||||.||.|:||.|.
Mouse  1633 EIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRA 1697

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||
Mouse  1698 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1762

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||
Mouse  1763 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1827

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:|:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||
Mouse  1828 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1892

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:..||:||||.|.||||||||||:||..::|.|.|.|
Mouse  1893 EEQSNTNLSKFRKIQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/36 (22%)
MYSc 81..777 CDD:214580 448/706 (63%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 428/675 (63%)
Myosin_tail_1 842..1897 CDD:279860 558/1055 (53%)
V_Alix_like 1557..1877 CDD:187408 171/319 (54%)
ATP-synt_B <1671..1771 CDD:304375 47/99 (47%)
TMPIT 1739..>1825 CDD:285135 50/85 (59%)
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 8/36 (22%)
Myosin_head 88..773 CDD:278492 436/687 (63%)
Motor_domain 100..773 CDD:277568 428/675 (63%)
Myosin_tail_1 853..1930 CDD:279860 575/1077 (53%)
RILP-like 968..1101 CDD:304877 63/132 (48%)
MIT_CorA-like <1302..>1414 CDD:294313 59/111 (53%)
DUF342 <1673..1770 CDD:302792 46/96 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1105 1.000 Domainoid score I20
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2092 1.000 Inparanoid score I42
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm43784
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.870

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