Protein Alignment Mhc and Myh2

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001034634.2
• Gene: Myh2 / 17882
• MGIID: 1339710
• Length: 1942
• Species: Mus musculus
• Alignment Length: 1925
• Identity: 1066/1925 - (55%)
• Similarity: 1429/1925 - (74%)
• Gaps: 16/1925 - (0%)

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDL 76
            :..|||..|.::|...|::|:|:|.|.::.:.||.::.|.|::.....|:|..:.|.|..:|:|.
Mouse    12 EAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATLTVKEDQ 76

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:|||||:|.|||:.:|:|::.:||:||::||...:||||||||||.:||||..|||......
Mouse    77 IFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Mouse   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   205 TDEA--AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:||  .|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Mouse   207 KEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||.|...|.:.::.|:|.|.|||..||||:::||||||.||...||
Mouse   272 EKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::|:|.|.
Mouse   337 SAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.|:||||::|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
Mouse   402 LCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM 527
            |||||::|..||||||||||||||||||||||||||||::||||||||||||||..||:||||||
Mouse   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...||||||.|||||..| |:..|||::.||||.|.|||||
Mouse   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVK-GKAEAHFSLIHYAGTVDYNITG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF-----ADHAGQSGGGEQAKGGRGKKGGGFATVSSAY 652
            ||:|||||||:|||..::||..|.|..:|     |:....|||.  ||.|..|||..|.|||:.:
Mouse   596 WLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGA--AKKGAKKKGSSFQTVSALF 658

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            :|.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.
Mouse   659 RENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYA 723

  Fly   718 DFKMRYKIM-CPKLLQGVEKD-KKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            |||.|||:: ...:.:|...| |||:|.::..||:...||:.|:|||||:||:||.:||.||::|
Mouse   724 DFKQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 788

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||:|:|..::|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|
Mouse   789 AQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETE 853

  Fly   846 DEIARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:|. ::|..:|.| |||||.....||.||..|...:..|...|.|.:||..:|..
Mouse   854 KEMATMKEEFQKTKDDLAKSEAK-RKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIK 917

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
Mouse   918 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 982

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
Mouse   983 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1047

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||::.|:|..|::|::.:::|:.|:|::.:|:||||.:.::.|
Mouse  1048 EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQ 1112

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
Mouse  1113 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1177

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.|
Mouse  1178 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1242

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.::..|...||:.:.|:..::|::||.:|..|.:||....:.:|..|:.:..|||:|.|:.|||
Mouse  1243 ETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQ 1307

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||
Mouse  1308 LSRGKQAFTQQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1372

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            :|...||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.|
Mouse  1373 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1437

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:..||||::|.||||..:||
Mouse  1438 DVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQL 1502

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
Mouse  1503 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1567

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
Mouse  1568 IQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEM 1632

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|:|:..|||.:|.:..|..|||.|..|::..|.::|.:|||.:.|||||.||.|:||.|.
Mouse  1633 EIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRA 1697

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||
Mouse  1698 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1762

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||
Mouse  1763 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1827

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:|:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||
Mouse  1828 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1892

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:..||:||||.|.||||||||||:||..::|.|.|.|
Mouse  1893 EEQSNTNLSKFRKIQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	12/41 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	426/675 (63%)
		Myosin_tail_1	842..1922	CDD:460256	575/1080 (53%)
Myh2	NP_001034634.2	Myosin_N	33..77	CDD:460670	13/43 (30%)
		Motor_domain	100..773	CDD:473979	426/675 (63%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	662..684		18/21 (86%)
		Myosin_tail_1	853..1930	CDD:460256	575/1077 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1130..1175		37/44 (84%)