DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh11

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	1939	Identity:	775/1939 - (39%)
Similarity:	1179/1939 - (60%)	Gaps:	31/1939 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSK-PYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDIKS 74
            |...:|||.........:: .:.:||..|:|.||:|:....||..|||.|.|.| :.|:...:..
Mouse     9 DDEKFLFVDKNFMNSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGK 73

  Fly    75 EKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRC 139
            :.::|:|||||.|:||||::|.||...||||||:||::.|||||||||||.:||||..|:|:.:.
Mouse    74 DDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKI 138

  Fly   140 AKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKK 204
            ..||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|.|
Mouse   139 VDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHK 203

  Fly   205 -------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADI 262
                   |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||:|
Mouse   204 GKKDSSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 268

  Fly   263 ETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEE 327
            |||||||:|.|.|...||::||||.:::|:...:|. .||.::...|..:|.|.|.:.:..|.|.
Mouse   269 ETYLLEKSRAIRQARDERTFHIFYYLLAGAKEKMKS-DLLLESFNSYTFLSNGFVPIPAAQDDEM 332

  Fly   328 FSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTA 392
            |..|.:|..|:||.::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:..
Mouse   333 FQETLEAMSIMGFNEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVT 397

  Fly   393 ELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFI 456
            :..:.:|.||||||.:.|.:.:..:|...:|.||.|..::|||:|::.:.|:.|| |.::...|:
Mouse   398 DFTRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFL 462

  Fly   457 GVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACID 521
            |:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.|||||:||..||:
Mouse   463 GILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIE 527

  Fly   522 LIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583
            |||:   |.|:|::|:||..||||||::|.|||.:.. |....|||||..|   ....|:|.|||
Mouse   528 LIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQ-GNHPKFQKPKQLK---DKTEFSIIHYA 588

  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGRGK 640
            |.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:.|
Mouse   589 GKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTK 653

  Fly   641 KGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRI 705
            | |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||||
Mouse   654 K-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRI 717

  Fly   706 CRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVL 769
            ||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|||
Mouse   718 CRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVL 782

  Fly   770 GQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQK 834
            ..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:.|
Mouse   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK 847

  Fly   835 VKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQD 899
            |||||.|:|.|:|:...||:.:|.:|.........||||..:.:|..|||.|.:.|..|.....:
Mouse   848 VKPLLQVTRQEEEMQAKEEEMQKIKERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETELYAE 912

  Fly   900 YQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAE 964
            .:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||.:
Mouse   913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

  Fly   965 QDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQT 1029
            .:|.|.:.:|:.|.|:|...|:..:||:||:|:..|........|...|:|..:|.|:|:|.|..
Mouse   978 LEKVTAEAKIKKLEDDILVMDDQNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHESM 1042

  Fly  1030 LDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLE 1094
            :.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:|:
Mouse  1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

  Fly  1095 DEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQ 1159
            :|........::|:||:..|.:|:|::::||.||.|||||:.||..|||.|...||:...:|:.|
Mouse  1108 EEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

  Fly  1160 IELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYY 1224
            .||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|....
Mouse  1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLE 1237

  Fly  1225 GQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQ 1289
            .:..||...:..:...|...|...|:|:..|.::|||..:..|...:......||..|...:...
Mouse  1238 KENADLAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGM 1302

  Fly  1290 LEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKA 1354
            |.|||.:..:|:|...||.:||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.|.
Mouse  1303 LNEAEGKAIKLAKDVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQ 1367

  Fly  1355 DLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQR 1419
            :|:|.:|..|.:....:.|.: |..:..|.:||.|::||..:....:..|........|||||.|
Mouse  1368 NLERHVSTLNIQLSDSKKKLQ-DFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLEKTKNR 1431

  Fly  1420 LSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLK 1484
            |..|::||.:::|....:.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...|.
Mouse  1432 LQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

  Fly  1485 GAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAA 1549
            .|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|..
Mouse  1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

  Fly  1550 LEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMK 1614
            |:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.|...|
Mouse  1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

  Fly  1615 KKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANA 1679
            ||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..|::.:.:||:.......:|::|.:
Mouse  1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKAKS 1691

  Fly  1680 LQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHSDLDEL 1743
            |:.:|.:.:..|..|:|.|:||:.|..:..|:| :.:|.:| ::...||:||:.:..|..:|:|.
Mouse  1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-TLQDEKRRLEARIAQLEEELEEE 1755

  Fly  1744 LNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGK 1808
            ....:...::.:||.:.|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|.......|
Mouse  1756 QGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLQEVEGAVKAKLK 1820

  Fly  1809 KAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQK 1873
            ..:..||.::.:||.:::.|.|....|.|:|::.::::||:..|.|::||..|:.::..:|...|
Mouse  1821 STVAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEVLLQVEDERKMAEQYKEQAEKGNTK 1885

  Fly  1874 IKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            :|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
Mouse  1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	15/37 (41%)
		MYSc	81..777	CDD:214580	356/715 (50%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	336/684 (49%)
		Myosin_tail_1	842..1897	CDD:279860	353/1055 (33%)
		V_Alix_like	1557..1877	CDD:187408	100/320 (31%)
		ATP-synt_B	<1671..1771	CDD:304375	28/100 (28%)
		TMPIT	1739..>1825	CDD:285135	27/85 (32%)
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160	16/37 (43%)
		MYSc_class_II	99..778	CDD:276951	336/684 (49%)
		Myosin_tail_1	855..1935	CDD:366712	361/1081 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8157
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720