Protein Alignment Mhc and Myh1

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_109604.1
• Gene: Myh1 / 17879
• MGIID: 1339711
• Length: 1942
• Species: Mus musculus
• Alignment Length: 1925
• Identity: 1066/1925 - (55%)
• Similarity: 1430/1925 - (74%)
• Gaps: 16/1925 - (0%)

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDL 76
            :..|||..|.::|...|:||:|:|.|.::.|.||.::...:::.:|..|:...:||.|..:|.|.
Mouse    12 EAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESFVKATVQSREGGKVTAKTEGGTTVTVKDDQ 76

  Fly    77 LQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:|||||:|.|||:.:|:|::.:||:||::||...:||||||||||.:||||..|||......
Mouse    77 VYPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
Mouse   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 206

  Fly   205 TDEA--AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:||  .|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
Mouse   207 KEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||||...|.:.::.|:|.|.|||..||||::||.||||.||...||
Mouse   272 EKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..|:..:|::|.||||.|.|||||:.||||||.||.|...:.:.|...::|:|.|.
Mouse   337 SAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.||||.||:|||.|.|::::|.|:|.:.|:.|||:|.||:||||||||
Mouse   402 LCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM 527
            |||||::|..||||||||||||||||||||||||||||::|||||.||||||||..||:||||||
Mouse   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...|||||..||||||.| |:..|||::.||||.|.|||.|
Mouse   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAK-GKVEAHFSLVHYAGTVDYNIAG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHA----GQSGGGEQAKGGRGKKGGGFATVSSAYK 653
            ||:|||||||:|||..::||..|.|..:|:..|    .:||||...||.: |||..|.|||:.::
Mouse   596 WLDKNKDPLNETVVGLYQKSSMKTLAYLFSGAAAAAEAESGGGGGKKGAK-KKGSSFQTVSALFR 659

  Fly   654 EQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPD 718
            |.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.|
Mouse   660 ENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 724

  Fly   719 FKMRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            ||.|||::....:   |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.||::|
Mouse   725 FKQRYKVLNASAIPEGQFID-SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 788

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||||:|..::|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|
Mouse   789 AQLITRTQAMCRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETE 853

  Fly   846 DEIARLEEKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:||:| |..||.| |||||.....|:.||..|...:..|..:|.|.:||..:|..
Mouse   854 KEMANMKEEFEKAKENLAKAEAK-RKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIK 917

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
Mouse   918 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 982

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
Mouse   983 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1047

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||:..|:|.:|::|::.:::|:.|:|::.:|:||||.:.::.|
Mouse  1048 EKKIRMDLERAKRKLEGDLKLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQ 1112

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
Mouse  1113 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1177

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.:
Mouse  1178 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1242

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.|:..|...||:.:.|:..::|:::|.:|..|.:|:..|.:.:|..|:.:..|||:|.:|.|||
Mouse  1243 EVISKSKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQ 1307

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.::.|....::..||.|.||||.|||.|.||:|||.:||||
Mouse  1308 LSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1372

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            :|...||:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..||||||||..|||||.:
Mouse  1373 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1437

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:.|||||::|.||||..:.|
Mouse  1438 DVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDHL 1502

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
Mouse  1503 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILR 1567

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
Mouse  1568 IQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1632

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|:|:..|||.:|.:..|..|||.|..|::..|.::|.:|||.:.|||||.||.|:||.|.
Mouse  1633 EIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRA 1697

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||
Mouse  1698 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1762

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|||
Mouse  1763 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVR 1827

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|.||||.|||
Mouse  1828 ELEGEVENEQKRNVEAIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEA 1892

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:.:|||||||.|.||||||||||:||..::|.|.|.|
Mouse  1893 EEQSNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	12/41 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	424/675 (63%)
		Myosin_tail_1	842..1922	CDD:460256	575/1080 (53%)
Myh1	NP_109604.1	Myosin_N	33..77	CDD:460670	13/43 (30%)
		MYSc_Myh1_mammals	100..773	CDD:276875	424/675 (63%)
		Actin-binding. /evidence=ECO:0000250	662..684		18/21 (86%)
		Actin-binding. /evidence=ECO:0000250	764..778		8/13 (62%)
		Myosin_tail_1	853..1930	CDD:460256	575/1077 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1175		17/18 (94%)