DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and nmy-3

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_501620.2	Gene:	nmy-3 / 177750	WormBaseID:	WBGene00012437	Length:	1464	Species:	Caenorhabditis elegans

Alignment Length:	1610	Identity:	484/1610 - (30%)
Similarity:	800/1610 - (49%)	Gaps:	217/1610 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGY-LLGEIKATKGDIVSVGLQGGEVRDIKSE 75
            |..|.:...|:.::::: :..|.....||.|:..|| ::..|.....|:: ||.: .|....:.:
Worm     8 DLEPNILRHLQTKKVEE-RIEDLNNQIWIEDDLYGYRMVTVIDEGLSDLL-VGFR-DEQGFFEKK 69

  Fly    76 KVEKVN---PPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTN 137
            ::||..   |......||:..:|..|...||:.|:.||.:.:|:|:.|||||.|||::..|:|::
Worm    70 RIEKTKCEVPSLNNYSEDLCTLTQPNAATVLNALKIRYTSNVIHTFCGLFCVVINPWRNIPIYSD 134

  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202
            ...::|  :.:|::|||:::::..|:..:|....|||:||||||||||||||||:|.:..:...|
Worm   135 EVKQLY--QLQNDLPPHVYSVAQNAFHGILKGGRNQSILITGESGAGKTENTKKIIDFILSSSVS 197

  Fly   203 KKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            ..|         :.|.||.:..:|||.|||:|..|.|||||||||||.|....||.||.||.|||
Worm   198 NNT---------IGDCVVTSGVLLEAMGNARTTHNSNSSRFGKFIRIEFDENSKLIGAKIECYLL 253

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGV-KDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLT 331
            ||:||:.|...:|::|||||::|...... |....|:..:.:|..:....   :.|||||...:|
Worm   254 EKSRVVFQSDGDRNFHIFYQMLSNYFDNPHKSFLKLSKKVNEYKYLRNDD---SMIDDAETAKMT 315

  Fly   332 DQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYK 396
            |:||..:|.:::||..:::|.:||:.:|.:||.:|...:.:..:..:|...:::|....:::|..
Worm   316 DEAFTRIGLSEEEKIWIFQILSAVLWIGDIKFGERSGLDVSFVESMQEVDNIAELLEMKSSKLVD 380

  Fly   397 NLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL---DTQQ--KRQHFI 456
            .|.:|.|||.::.:.:.:|:.:..:|..|:.|.:::|||.|:||:||:..   ||:.  :...||
Worm   381 ALTQPTIKVHDKLIRKNQNLAKTLSSASAMAKILYERLFGWIVKRCNDAFSVDDTESTCRLSRFI 445

  Fly   457 GVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACID 521
            .|||||||||.|.|.|||.|||:|||||||||||.||..||.:|..|||.|..::|...|...||
Worm   446 AVLDIAGFEIIEKNSFEQFCINYTNEKLQQFFNHFMFAKEQSDYLEEGIKWTQVNFANHLQPTID 510

  Fly   522 LIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCV 586
            ||||||||||.||||.:.|..::::..|||. ::|...:.|:|.|..:......||.:.||||.|
Worm   511 LIEKPMGILSFLEEECVVPNGSEKSLLEKLC-SNLSNDSSFKKSKQTQKCSTIRHFYVQHYAGEV 574

  Fly   587 SYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA 651
            .|||.|||:||:|.:..:|:|...:|.:.||..:|......:     .|..||....  :|||..
Worm   575 HYNIDGWLDKNRDNVETSVLDILSQSTHPLLKLLFPPVPVNN-----LKTRRGTITN--STVSFL 632

  Fly   652 YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMY 716
            ||.||..|:.||.|:..||:||::.|..|.||.:||.||:.||.||||||||||||:|:|:|:.:
Worm   633 YKNQLQCLLDTLNSSSAHFIRCVVSNYEKLPGKIDAPLVLAQLKCNGVLEGIRICREGYPSRLSH 697

  Fly   717 PDFKMRYKIMCPKLLQGVEKDKKATE-----IIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFR 776
            .:|..||.:    |::..|:.|.|:|     :|.:...:.:::|.:|.||:|.:.||:.::|..|
Worm   698 SEFIERYSL----LMKNKEQSKGASEKEKCTLICQDAQVRKERYAVGKTKLFCKVGVISELETKR 758

  Fly   777 DERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVV---QRNLRKYLQLRTWPWYKLWQKVKPL 838
            :..:...:..:||..| ||:.:  |.|.|:|..|:.|   |.|:|::.:|..||||:::...:.|
Worm   759 NNYISSFIILIQANIR-YLNIQ--KDLIERRKKLEAVVTIQDNVRQFAELSQWPWYRIYHLTRGL 820

  Fly   839 LNVSRIEDEIARLE-EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQE 902
            :..:|.::.|..|| ||.|..||:...|:|..:.|:. |.||    :.|||            :|
Worm   821 IPRNRDKERIEELENEKLKLEEEIQEMEIKNEEALKE-NLKL----SMLLD------------RE 868

  Fly   903 RNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELN--VQKAEQ 965
            ::.|:..||     :|.::      |:..|.:|.:::::       .:|.:|::|.|  :....:
Worm   869 KSEKVKVQK-----ELEEV------EKQGREKLLEKERE-------FRKTMEEMEQNEEIFNVLE 915

  Fly   966 DKATKDH-QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQT 1029
            .|..:.| ::..:||.:...:..|.:||.||......|||..|.....:...::|.|...:....
Worm   916 RKYNEQHKKVMKMNDVLREYERKIEQLNMEKTDLENENQKLRETQNRQDSHYSNLEKEVMEKSSL 980

  Fly  1030 LDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLE 1094
            :|||::.:::                         ::| |.|::.|         .::.:...||
Worm   981 IDELQNQIQK-------------------------LSD-ENNEQRL---------TIAKLETALE 1010

  Fly  1095 DEQVVVLKHQRQIKELQARIEELEEEVEA-------ERQARAKAEKQRADLARELEELGERLEEA 1152
            ||:....:....|.::|..|.||.|::..       ||.:..|.|:::..|..||....|.:::.
Worm  1011 DEKARFARQNNTIGDMQKLISELNEKIARFDNIALNERNSTRKIEREKEKLNEELTTAKEIIQKQ 1075

  Fly  1153 GGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAE 1217
            ........|..:||:.|.|:|.|.||:........:..|:..|.:.:.||.::|:.:.:..:|.|
Worm  1076 AKKIDELKEECRKRKNEASRLERKLEDKEAMMADCVKELKDSHKERLKEMEQKVEDVKRKNSKLE 1140

  Fly  1218 KEKNEYYGQLNDLR----AGVDHITNEKAAQEKIAKQLQHT-------------------LNEVQ 1259
            .|.:....|:...:    ...|:..:.......:.:|...|                   ::::.
Worm  1141 NENSTQKSQIETFQRESSVDSDYGRSSSGRLSTLGRQYSLTSIGSFSSIRTVGLGSRKDSISDMT 1205

  Fly  1260 SKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR-------- 1316
            |.:....|..:.:|.:...:.::.|....|:.|.|.::.:|.|.|.::.|.|:..||
Worm  1206 SSMYSLRRRDSTYDMTSSTIGLQRSPSTSQVMEKERRILELEKEKAAINTDLQLVKRELDVYKSQ 1270

  Fly  1317 LADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGV-A 1380
            |:..|| |:.:|....|...:.|.....|:....:...:|..:|.||.|:...|:.|:|...| :
Worm  1271 LSAVES-EKESLQTANRKQSNQLQETTRQLNSAQKNADNLALRLKKALADCDEWKKKHEESIVES 1334

  Fly  1381 RSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQ 1445
            ::|.|.|.||.:. |....|:..|....:...:|..:..|..|:...|.|:||...|....|:..
Worm  1335 KTEILMERKRAMD-RAEACEKETELKQSRMATIESARMELGGELARTQSELDRCRQIIIQLEENL 1398

  Fly  1446 KAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL-EAVRRENKNLADEVK 1509
            |:                                           ||.| .:..|...||..|::
Worm  1399 KS-------------------------------------------QESLGNSFGRHQTNLNFEIE 1420

  Fly  1510 DLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            :|.|:        :...||:.|.:.::.||....:|....|...||||.|
Worm  1421 NLRDE--------NCALKAKIRRQYKQIELLTQQDETNDELNHFENKVER 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/37 (27%)
		MYSc	81..777	CDD:214580	286/709 (40%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	278/675 (41%)
		Myosin_tail_1	842..1897	CDD:279860	161/762 (21%)
		V_Alix_like	1557..1877	CDD:187408	2/3 (67%)
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
nmy-3	NP_501620.2	MYSc_class_II	97..747	CDD:276951	278/675 (41%)
nmy-3	NP_501620.2	Smc	864..>1463	CDD:224117	146/717 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820