Protein Alignment Mhc and hum-8

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001294574.1
• Gene: hum-8 / 176872
• WormBaseID: WBGene00002041
• Length: 1279
• Species: Caenorhabditis elegans
• Alignment Length: 1242
• Identity: 353/1242 - (28%)
• Similarity: 571/1242 - (45%)
• Gaps: 253/1242 - (20%)

  Fly    23 QRRIDQ------SKPYDSKKSCWIPDEKEGYLLG---EIKATKGDIVSVGLQGGETRDLKKDLLQ 78
            :||.::      ..|.|..::.||.|..:|:...   ::.||...:..:...|.....:.:|:|.
 Worm    58 ERRAEKVGINVSQPPPDYGRTVWITDATDGFRAARIIDLSATGFTLRLLDNTGDTVTRVFEDVLA 122

  Fly    79 QVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYP-VYTNRCAKM 142
            ..:..: ...||...|.:||:|::|:|:|.||.|..||:|.....::||||:... .|:.:..|.
 Worm   123 CEDDSR-RHVEDNCQLMHLNEATLLNNIRLRYQNGKIYSYVANILISINPYQTIDGFYSLQKIKE 186

  Fly   143 YRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDE 207
            ||||...:..||||||:|.:|.:|:.:..:||::::|||||||||:.|.|:.|..        :.
 Worm   187 YRGKSLGQKEPHIFAIADKSYREMIRHRKSQSIIVSGESGAGKTESQKAVLRYLC--------EN 243

  Fly   208 AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARV 272
            .....|.::.::::|||:|||||||||:||:||||||||::|||..||.:||..:..||||.:|:
 Worm   244 WGSGAGEIQKRLLETNPILEAFGNAKTLRNNNSSRFGKFVQIHFADTGNVAGGYVSHYLLETSRI 308

  Fly   273 ISQQSLERSYHIFYQIMSGSVPGV-KDICLLTDNIYDY----------------------HIVSQ 314
            ..|.:.||:||||||:::||.|.: |.:.|...|.::|                      :.:|.
 Worm   309 CRQAAGERNYHIFYQLIAGSSPELFKFLALGQPNQFNYLKRGFIGFFTHPSSGTTSKIPKNRLSD 373

  Fly   315 GKVTVAS-IDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE 378
            .|.|..| :||..:|...:.|..:.|.::||...::...||::|:|.::|     ||..:   :.
 Worm   374 PKFTQDSMVDDFSDFQRLEYALKLTGLSEQEIHFIWTTIAAILHLGNVEF-----EESLD---DS 430

  Fly   379 EGG------------RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ------QVTNSIGA 425
            .||            :.::|.|.:|.|| |..|..||....:...:|..::      :..:...|
 Worm   431 RGGCKVFNGSEQDLIQAARLLGLETMEL-KMGLCARIMQTTKGGARGTLIRVPLKPHEACSGRDA 494

  Fly   426 LCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNH 490
            |.|.::.:||.|||.:.|:::.. :|..:|:||||:||||.:..|.|||.||||.|||||.|||.
 Worm   495 LSKAIYSKLFDWLVSRINDSIPF-EKSTNFVGVLDVAGFEFYAKNSFEQFCINFCNEKLQNFFNQ 558

  Fly   491 HMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNT 554
            .:...|||.|::||:....|:| :|.|.||:|.| |..|:..:|:||:.||.:..::|:::   .
 Worm   559 RILREEQELYEKEGLNVRKIEF-IDNQDCIELFELKGNGLFDLLDEEAKFPTSNYKSFTKR---A 619

  Fly   555 HLGKSAPFQKPKPPKPGQQAAH--------FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            |......|:...|.| .:..:|        ..|.||||.|.|....::|||.|.|::::....::
 Worm   620 HEENRKHFRLDTPRK-SKVKSHRELRDDEGLLIRHYAGSVCYETKHFVEKNDDLLHNSLQILIEQ 683

  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676
            |..:||:.:|...|..:....:|           .:|.:.:|.||::|:..|.||..||||||.|
 Worm   684 STIRLLVSLFGSTAYPTKSKLKA-----------LSVGAKFKNQLSTLLIKLESTGTHFVRCIKP 737

  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT 741
            |....|...|...::.||.|.|:...:::.:.|||:|..:.|....|:...|..|..:: .:...
 Worm   738 NNQMIPFEFDGSAILSQLQCAGMTSVLKLMQDGFPSRTGFGDLYACYQKKLPPKLSKLD-PRMFC 801

  Fly   742 EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDE-------RLGKIMSWMQ----------- 788
            :.:.:.:.|.:..::.|.||||||||...:.::...:       .:.|:..|:.
 Worm   802 KCLFRALGLDQHDFQFGLTKVFFRAGKFAEFDQMMKQDPETMTSLIQKVNEWLVGARWKQSQYAV 866

  Fly   789 ----------AW-----------ARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832
                      ||           |||||:|:.|.:    ::||      .||.:.|
 Worm   867 WSVIKLKNKIAWRSAQVTRLQSIARGYLTRQRFSR----QIAL------YRKSVAL--------- 912

  Fly   833 QKVKPLLNVSRIEDEIARLEE--KAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKG 895
                 |.|...||..:.||.|  :||.....|:    ..::||.|.:.:
 Worm   913 -----LKNSKEIEKILFRLNEHSRAKYTSSAHS----TIRDLEKLVSHI---------------- 952

  Fly   896 ALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNV 960
                      |||...||             ..|.|.|......|:.|..|:.|||
 Worm   953 ----------KLTTSAND-------------HFEKAENAYEHYVKRVDSMIADLKK--------- 985

  Fly   961 QKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAK 1025
                |.|:.:..:|.....|...::.|..:..||.:.|.|..:|..|:.|.|:.:  |.|.:.::
 Worm   986 ----QQKSDELAEIERKRRESEEKERLEIEAKKEAERQREIKRKLEEQQQNAQKE--HENYLISE 1044

  Fly  1026 LEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSIT 1090
            :.:..:|.|...:.|:|.:.|...|.|..|.|      .|| |..:|.|:|.         ||.:
 Worm  1045 IHKAAEETEKKRQNEEKEKLDKMVSNRLAEAD------GVA-LISSKMEIEP---------SSGS 1093

  Fly  1091 AKLEDEQVVV-----------LKHQRQIKELQARIEELEEEVEAERQARAK-AEKQ-----RADL 1138
            |...|.:..|           :.....|..|:|..||....:....:.::: |..|     ||.|
 Worm  1094 ATFRDGKYDVGGCSFAYLRDTINTSMDINLLKACEEEFRRRLRIYNEWKSRNAPVQDRPPARAAL 1158

  Fly  1139 ARELEEL 1145
            :...|||
 Worm  1159 STVCEEL 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	8/44 (18%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	240/716 (34%)
		Myosin_tail_1	842..1922	CDD:460256	73/323 (23%)
hum-8	NP_001294574.1	MYSc_Myo6	143..825	CDD:276833	240/716 (34%)
		CBD_MYO6-like	836..987	CDD:409646	43/230 (19%)
		tolA_full	983..>1076	CDD:274303	26/107 (24%)
		MyUb_Myo6	1099..1139	CDD:439319	6/39 (15%)
		Myosin-VI_CBD	1180..1276	CDD:465157