DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and unc-15

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001379131.1	Gene:	unc-15 / 172491	WormBaseID:	WBGene00006754	Length:	872	Species:	Caenorhabditis elegans

Alignment Length:	851	Identity:	336/851 - (39%)
Similarity:	548/851 - (64%)	Gaps:	20/851 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1085 ELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERL 1149
            :|.|:| :|||                 :|..|:|::|:||:.|.:.|::||||:.::..|.:||
Worm    31 DLGSLT-RLED-----------------KIRLLQEDLESERELRNRVERERADLSVQVIALTDRL 77

  Fly  1150 EEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKA 1214
            |:|.|.|.:|||.|:|||.||||||:.|||:.::.|..:..|||||.|:..:..:|::||.|..|
Worm    78 EDAEGTTDSQIESNRKREGELSKLRKLLEESQLESEDAMNVLRKKHQDSCLDYQDQIEQLQKKNA 142

  Fly  1215 KAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKL 1279
            |.::|:.....::.:|.|.:|.:..:|...||.|::.:...||:.:|:::.|:.:||....:::|
Worm   143 KIDRERQRVQHEVIELTATIDQLQKDKHTAEKAAERFEAQANELANKVEDLNKHVNDLAQQRQRL 207

  Fly  1280 SIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLRE 1344
            ..||:|||:::.:.:.|:..|..:|.:|..|||:.:|..::..|||:.|..:...::.:||::|.
Worm   208 QAENNDLLKEVHDQKVQLDNLQHVKYTLAQQLEEARRRLEDAERERSQLQSQLHQVQLELDSVRT 272

  Fly  1345 QVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQK 1409
            .::||:..::|.:.:|:.||.|...|:||::::.....||:|:.::|:..:.||.||.||.:.||
Worm   273 ALDEESIARSDAEHKLNLANTEITQWKSKFDAEVALHHEEVEDLRKKMLQKQAEYEEQIEIMLQK 337

  Fly  1410 CIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECR 1474
            ...|||.|.||.:|||.|.:::::|.......|:.::..::.:||.|:::|::..||:|:|:|.|
Worm   338 ISQLEKAKSRLQSEVEVLIVDLEKAQNTIALLERAREQLERQVGELKVRIDEITVELEAAQRELR 402

  Fly  1475 NYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL 1539
            ..:.||.::|..||:..||.||:.||||.|.||:.:..:.:.:..|.:||::....||..|..||
Worm   403 AVNAELQKMKHLYEKAVEQKEALARENKKLHDELHEAKEALADANRKLHELDLENARLAGEIREL 467

  Fly  1540 QAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASL-EAE 1603
            |.||:||:|.....||:..||..||..:|.|::||:||||||.|..|||.|..:|.:.|:| :||
Worm   468 QTALKEADAQRRDAENRAQRALAELQALRIEMERRLQEKEEEMEALRKNLQFEIDRLIAALADAE 532

  Fly  1604 AKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDARE 1668
            |:.|:|..|:|||.:|:|.|||:.:|:.|:||.||||.||:..:|||.:|.:||:.||......:
Worm   533 ARMKSEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKILQASLEDTQRQLQQVLD 597

  Fly  1669 QLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESEL 1733
            |..:::|:..||..||||.:|.|:.|.|.|:|||.:|.:|:.:::::.:.|.::::.|.|||:||
Worm   598 QYALAQRKVAALSAELEECKTALDNAIRARKQAEVDLEEANGRISDLISINNNLTSIKNKLETEL 662

  Fly  1734 QTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDE 1798
            .|..:||||:..|...::|:|.:|:.||||..::|..||:|:...:.|||:||:|:|:|||::.|
Worm   663 STAQADLDEVTKELHAADERANRALADAARAVEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQE 727

  Fly  1799 AEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERM 1863
            |||.||.|||:.|.|||.|:|:||..||.|.|||.:.|..|||.:||:||:....:|:.||....
Worm   728 AEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQQLVDEEHKNFVMA 792

  Fly  1864 QDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSV 1928
            ||..|:|.:|:...|||:.|:|.:...||.:.|:.|.|||:||.|||.||.::...|||.|:..|
Worm   793 QDTADRLTEKLNIQKRQLAESESVTMQNLQRVRRYQHELEDAEGRADQAESSLHLIRAKHRSSVV 857

  Fly  1929 -GRGAS 1933
             |:.:|
Worm   858 TGKSSS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874
		Myosin_tail_1	842..1897	CDD:279860	317/812 (39%)
		V_Alix_like	1557..1877	CDD:187408	145/320 (45%)
		ATP-synt_B	<1671..1771	CDD:304375	38/99 (38%)
		TMPIT	1739..>1825	CDD:285135	43/85 (51%)
unc-15	NP_001379131.1	Myosin_tail_1	<32..839	CDD:396244	325/824 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910