Protein Alignment Mhc and myo-1

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 1951
• Identity: 1002/1951 - (51%)
• Similarity: 1365/1951 - (69%)
• Gaps: 43/1951 - (2%)

  Fly     8 QEDEDP-TPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIK--ATKGDIVSVGLQGGEV 69
            :.::|| ..||..|.||:..|||:||||||:.||||.:|||:.|.||  ..|.|.|.| ..||:.
 Worm     4 EHEKDPGWQYLKRSREQQLADQSRPYDSKKNVWIPDAEEGYIEGVIKGPGPKADTVIV-TAGGKD 67

  Fly    70 RDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPV 134
            ..:|.:.|::||||||||.|||:::|.||...||.|||.||.|.|||||||||||.||||||.|:
 Worm    68 VTLKKDIVQEVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRLPI 132

  Fly   135 YTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV 199
            ||:..|:|:.||||.|:|||:||:||.||..||.:|.||||||||||||||||||||||.|||||
 Worm   133 YTDSVARMFMGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYFATV 197

  Fly   200 GASKKTDEAAKSKG----SLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            |||:|   ||..:|    :||||:||||||||||||||||||:|||||||||||||...|.||..
 Worm   198 GASQK---AALKEGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASC 259

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325
            |||.|||||:|||.|...||.|||||||.|...|.::|..||...|.:|..|:|.::.:..|||.
 Worm   260 DIEHYLLEKSRVIRQAPGERCYHIFYQIYSDFKPQLRDELLLNHPISNYWFVAQAELLIDGIDDT 324

  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390
            |||.|||:|||:|.|:..||.|.||:.:|.||||.||||||.||||||.||::|..|...::|.|
 Worm   325 EEFQLTDEAFDVLKFSPTEKMDCYRLMSAHMHMGNMKFKQRPREEQAEPDGQDEAERACNMYGID 389

  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK---R 452
            ..:..|.|:.||:|||.|:|::|:||.||..:|||:.||::.|:|.|||||||.|||  ||   |
 Worm   390 VDQFLKALVSPRVKVGTEWVSKGQNVDQVHWAIGAMAKGLYARVFHWLVKKCNLTLD--QKGIDR 452

  Fly   453 QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLL 517
            .:|||||||||||||::|.||||.|||.||||||||||||||||||||.||||.|.|||||:||.
 Worm   453 DYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQ 517

  Fly   518 ACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHY 582
            |||:|||||:||:|:|:||.:.|||||.|.::|||:.||||...|:||||||..|..||||:.||
 Worm   518 ACIELIEKPLGIISMLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPPKGKQGEAHFAMRHY 582

  Fly   583 AGCVSYNITGWLEKNKDPLNDTVVDQFKKS-QNKLLIEIFADHAGQSGGGEQAKGGRGKKG---G 643
            ||.|.||:..||||||||||||||...|.| :|.||:||:.|:..|......||.|.|:||   |
 Worm   583 AGTVRYNVLNWLEKNKDPLNDTVVSVMKASKKNDLLVEIWQDYTTQEEAAAAAKAGGGRKGGKSG 647

  Fly   644 GFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRK 708
            .|.|||..|:|.||.|||.|..|.|||:|||||||.||.|::||.||::||||||||||||||||
 Worm   648 SFMTVSMMYRESLNKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRK 712

  Fly   709 GFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFI----DLPEDQYRLGNTKVFFRAGVL 769
            |||||..:|||..||.|:..|..:..:..|.....|::.:    .|.::|:|:|:|||||:|||:
 Worm   713 GFPNRTQHPDFVQRYAILAAKEAKSSDDMKTCAGAILQALINQKQLNDEQFRIGHTKVFFKAGVV 777

  Fly   770 GQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQK 834
            ..:|:.||::|.:|::..|:..|.|.:.......::|..:..::|||:|.:..||||.|:.|:.|
 Worm   778 AHIEDLRDDKLNQIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRSWCVLRTWDWFLLFGK 842

  Fly   835 VKPLLNVSRIEDEIAR-------LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSG 892
            ::|.|...::.:|:.:       ||.:|||||       ..||..|...|||.||::.||::|..
 Worm   843 LRPQLKCGKMAEEMIKMAEEQKVLEAEAKKAE-------SARKSQEEAYAKLSAERSKLLEALEL 900

  Fly   893 EKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLE 957
            .:|.....:|:..:|.:.:.::|..|.|..:||::.|:....|.:|::||.||:..|||.||.::
 Worm   901 TQGGSAAIEEKLTRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQRRKAQQEVENLKKSIEAVD 965

  Fly   958 LNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKV 1022
            .|:.|:.::||.|::||.:|.||:..|||.|.|:|||||:..|.|::..::|||.|.|....|::
 Worm   966 GNLAKSLEEKAAKENQIHSLQDEMNSQDETIGKINKEKKLLEENNRQLVDDLQAEEAKQAQANRL 1030

  Fly  1023 KAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELS 1087
            :.||||||||:|:::||||::|.:.|||||||||:||..||.:.:|...|.|.:.::::|:.::.
 Worm  1031 RGKLEQTLDEMEEAVEREKRIRAETEKSKRKVEGELKGAQETIDELSAIKLETDASLKKKEADIH 1095

  Fly  1088 SITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEA 1152
            ::..::||||.:..:..||.||...||.|:|:|:|.|||:|:||::.||:|.|||:||.|||:|.
 Worm  1096 ALGVRIEDEQALANRLTRQSKENAQRIIEIEDELEHERQSRSKADRARAELQRELDELNERLDEQ 1160

  Fly  1153 GGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAE 1217
            ......|.:.|||:::|:.|.||||:|.|:.:|..:|.:|:|:||.::.:...:|.|.|.|||.|
 Worm  1161 NKQLEIQQDNNKKKDSEIIKFRRDLDEKNMANEDQMAMIRRKNNDQISALTNTLDALQKSKAKIE 1225

  Fly  1218 KEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIE 1282
            |||.....:|:|:.|.||..|..:..||::|||.:..:.|:|.|:||.:|.:.::.::|.:||.:
 Worm  1226 KEKGVLQKELDDINAQVDQETKSRVEQERLAKQYEIQVAELQQKVDEQSRQIGEYTSTKGRLSND 1290

  Fly  1283 NSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVE 1347
            ||||.||:||.|..::.:::.|.:.::||.:.|:.|::|..||.......:||||:||...|.:|
 Worm  1291 NSDLARQVEELEIHLATINRAKTAFSSQLVEAKKAAEDELHERQEFHAACKNLEHELDQCHELLE 1355

  Fly  1348 EEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG 1412
            |:..||.|:|||||:.|:|...|:::||.:|:..||||||.|||...|:.:.:|.:.:...|.|.
 Worm  1356 EQINGKDDIQRQLSRINSEISQWKARYEGEGLVGSEELEELKRKQMNRVMDLQEALSAAQNKVIS 1420

  Fly  1413 LEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYS 1477
            |||.|.:|..|.||.:.:|||...:..:.||||:|||||:.:||.||||:..|:||:.::.||.|
 Worm  1421 LEKAKGKLLAETEDARSDVDRHLTVIASLEKKQRAFDKIVDDWKRKVDDIQKEIDATTRDSRNTS 1485

  Fly  1478 TELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAA 1542
            ||:|:|:.:.:...||:|.:|||||..:.|::|:.:||.:|||...|:.|:.:|||.||||||.|
 Worm  1486 TEVFKLRSSMDNLSEQIETLRRENKIFSQEIRDINEQITQGGRTYQEVHKSVRRLEQEKDELQHA 1550

  Fly  1543 LEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGK 1607
            |:|||||||.||:||||.|:|:.|:|.||::||||||||||||||||||||:|:|||||.|||.|
 Worm  1551 LDEAEAALEAEESKVLRLQIEVQQIRSEIEKRIQEKEEEFENTRKNHQRALESIQASLETEAKSK 1615

  Fly  1608 AEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGI 1672
            ||..|.|||||.|||:||||||||||||.:||||:|:...|:|::|..:::|||.|::.||....
 Worm  1616 AELARAKKKLETDINQLEIALDHANKANVDAQKNLKKLFDQVKELQGQVDDEQRRREEIRENYLA 1680

  Fly  1673 SERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLH 1737
            :|:|.....:|.|:....:|.:|:.::|.|.|.|:......|:...||::||.|||:|:|:|...
 Worm  1681 AEKRLAIALSESEDLAHRIEASDKHKKQLEIEQAELKSSNTELIGNNAALSAMKRKVENEVQIAR 1745

  Fly  1738 SDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEAN 1802
            ::|||.|||.|.|||:|:||..||.|||:|:|.||:||...::.||:||...||||.::|:||..
 Worm  1746 NELDEYLNELKASEERARKAAADADRLAEEVRQEQEHAVHVDRQRKSLELNAKELQAKIDDAERA 1810

  Fly  1803 ALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLV 1867
            .::.|.||:.|:|.|||.||.||..|||||.::.|...|.|||.:||.||.|||:|..:|:|:.|
 Worm  1811 MIQFGAKALAKVEDRVRSLEAELHSEQRRHQESIKGYTKQERRARELQFQVEEDKKAFDRLQENV 1875

  Fly  1868 DKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGA 1932
            :||||||:..|||||||||:|..||:|||:.|..||.|||||::||.::.:.|     |.|.|.|
 Worm  1876 EKLQQKIRVQKRQIEEAEEVATQNLSKFRQIQLALENAEERAEVAENSLVRMR-----GQVVRSA 1935

  Fly  1933 S 1933
            :
 Worm  1936 T 1936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	17/38 (45%)
		MYSc	81..777	CDD:214580	440/710 (62%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	422/679 (62%)
		Myosin_tail_1	842..1897	CDD:279860	490/1061 (46%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	41/99 (41%)
		TMPIT	1739..>1825	CDD:285135	45/85 (53%)
myo-1	NP_492053.1	Myosin_N	33..71	CDD:280832	17/38 (45%)
		Myosin_head	86..773	CDD:278492	428/691 (62%)
		MYSc_class_II	98..773	CDD:276951	422/679 (62%)
		Myosin_tail_1	854..1918	CDD:279860	498/1070 (47%)
		P-loop_NTPase	<863..>1071	CDD:304359	91/214 (43%)
		DUF2213	<1074..1224	CDD:303028	59/149 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I24
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2227	1.000	Inparanoid score	I15
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm14456
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870