DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and LOC1278822

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_061507801.1 Gene:LOC1278822 / 1278822 VectorBaseID:AGAMI1_005641 Length:3010 Species:Anopheles gambiae


Alignment Length:2555 Identity:516/2555 - (20%)
Similarity:904/2555 - (35%) Gaps:823/2555 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 EQRRIDQSKPYDSKKSCW-IPDEKE--GYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQVNPP 83
            ::||:...:...|....| :..||:  .:.|.||::....:.|.||.....||....|||:.|  
Mosquito   103 KERRLSAHEKPVSVMLLWPMHSEKDFHRFYLREIQSDVPWLDSYGLDPQILRDFIPFLLQKEN-- 165

  Fly    84 KYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148
              .:..|:..|..||:|::|.|||||:....||||.|...:|:||:|.:|:|..:..::|:.:|.
Mosquito   166 --REYPDLCQLPDLNEATLLENLRQRFEAGHIYTYVGSILIAVNPFKFHPIYNPKYVRLYQNQRI 228

  Fly   149 NEV-PPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSK 212
            ..: |||||||:|.||.:||....||.::|:||||:||||:|..::.:...:     :.:.|...
Mosquito   229 GPILPPHIFAIADNAYYNMLKEKRNQCIVISGESGSGKTESTNFLLHHLTAL-----SQKGAHGS 288

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
            | :|..::...|||||||||||..|:|||||||||::::...|.:.||.::.|||||:|::||..
Mosquito   289 G-VEQTILSAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVQGAVVQKYLLEKSRIVSQGH 352

  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            .||:||:||.::||:....:|...|.. ...||.::...:|:.:.|:..|||...|:.:::||:.
Mosquito   353 YERNYHVFYYLLSGATDAERDALHLLP-AEKYHYLNAKNLTLENCDEKYEFSRLKQSMEMVGFSA 416

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQR----GREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI 403
            :::..::.:.:||:.:|.::|..:    ..:|..:....:..|.:|:|.......|...|...|:
Mosquito   417 EKQRRLFNVLSAVLLLGNVEFFPKKSTYHHDESVQVRNPDVVGLISELLRVKQETLMSALTSKRV 481

  Fly   404 KVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL---DTQQKRQHFIGVLDIAGFE 465
            |...|.:.....:.:...:..||.|.::..||.|:|.:.|..|   |......|.||||||.|||
Mosquito   482 KASGETLIMQYKLPEAIAARDALAKCLYGALFDWIVLQVNHALLNKDQVLHTGHSIGVLDIFGFE 546

  Fly   466 IF-EYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMG 528
            .| ..|.|||||||:.||.||.:||.|:|..||:||:||||:||.|:| :|...|:.|.| ||.|
Mosquito   547 DFGPQNSFEQLCINYANEHLQYYFNLHVFKYEQKEYKREGIKWTDIEF-LDNYGCLQLFESKPSG 610

  Fly   529 ILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGW 593
            :|.||::...||.||::|..:|..:.|  |...|.:    ||.::...|.|.||||.|.|.:...
Mosquito   611 LLCILDDLCNFPGATNETLLQKFNSVH--KDNAFYE----KPQRKENAFIIKHYAGKVKYQVAEM 669

  Fly   594 LEKNKDPLNDTVVDQFKKSQ--------------------------------------------- 613
            .|||.|.:...:|...|.|.                                             
Mosquito   670 REKNLDLMRQDIVSVLKNSSMAFVRELVGADPVAVFRWAILRAFFRGYFAFRSAGIKHRKERADM 734

  Fly   614 --NKL------------------------------------------------------------ 616
              |||                                                            
Mosquito   735 SYNKLATKTRYRAPNDSIVSHLVTVSSVNLTINRIAKLFCARRPVRDAGMLDRYRNYSTKSATAK 799

  Fly   617 -----------------LIEIFADHA-------------------------------GQSGGGEQ 633
                             :.:|.:.|:                               |.:||..:
Mosquito   800 GGQRERRKNWPKRISNAMSDITSGHSNNQACSPNSNLAYHRQSLGNAGYGAAGAASPGATGGTPR 864

  Fly   634 ------------------------------------------------AKGGRGK---------- 640
                                                            ..||.||          
Mosquito   865 RSWSSFAFNNKNFPDGKLNYECNQQQDQTPQYHSKHLQSTAASSSSIYGSGGGGKSSANANSSAS 929

  Fly   641 --------------KGGGFA--------------------------------------------- 646
                          ||.|..                                             
Mosquito   930 GAPNSGGVTGTGSGKGYGLGSAAARNRFERSGQDVMARASQIVMKNKSFRPRERPKKGLKNLQSV 994

  Fly   647 -----------------------TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAH 688
                                   ||::.::..|.:||.||....|.|:|||..|..|.|...|..
Mosquito   995 KTLSAGQNLSNQTSAIKTRKQPLTVTAQFQNSLIALMETLNQANPFFIRCIKSNPNKIPNQFDDA 1059

  Fly   689 LVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPED 753
            .|..||...|:||.:||.|.|:..|:.|.:|...|:|:.||.|...:||.:.   .:..:||.:.
Mosquito  1060 TVTRQLRYTGMLETVRIRRAGYNVRLTYEEFIQLYRILLPKGLVSSQKDVRD---FMSTMDLNKQ 1121

  Fly   754 QYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLR 818
            .|:||.||::.|.....:::.....::...:..:|.|.|..|.|   ||..:.|.|...:|...|
Mosquito  1122 HYQLGLTKIYMRESQKMRLDISLHTKIIDSIICIQRWFRAILQR---KKYCQYRNAACTIQSYWR 1183

  Fly   819 KYLQLR------------------TWPWY---KLWQKVKP--LLNVSRIEDEIARLEEKAKKAEE 860
            .||:.:                  ||..|   |.:.|:|.  |:..:||....||...|...:::
Mosquito  1184 DYLREKQEKFTRKIRNHAATVIQATWRGYTVRKWYSKLKTGVLIIQARIRGNQARSRFKELLSKK 1248

  Fly   861 LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGA-----------LQDYQERNAKLTAQKNDL 914
            |.....|:| ..::|..:.....||...|..|..|.           :...:.|...:.|.....
Mosquito  1249 LQRERAKLR-STQSLPVERPIGTTAAGGSYGGGGGGAGGGGSTYPEIVHAIEHRKKPIPAVGRSF 1312

  Fly   915 ENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLND 979
            |..: ||..:       ...||     ||..:|.   |..|.:.:.::.|:::.|...|      
Mosquito  1313 ETAI-DIVNK-------NRALF-----ADDSMSA---DFIDDDEDEEEEEEEETTGSRQ------ 1355

  Fly   980 EIAHQDELINKLNKEKKMQGETNQKTGEELQAAED---KINH----LNKVKAKLEQTLDELEDS- 1036
                  ..|.....|::...|.:::..|:|...:|   ..|:    ::.||.....|.....:| 
Mosquito  1356 ------ATITATCGEEEEDEEDDEEGYEDLGLVDDPQYMANNRSALMHPVKTAAPVTTSPTVNSA 1414

  Fly  1037 -LER-EKKVR-------------------------GDVEKSKRKVEGDLKLTQEAVADLERNKKE 1074
             |:| ||.::                         |:.......|.|..:     .|.|:|.:..
Mosquito  1415 LLDRNEKYIKSLVISGGGGGGATASSSPSAGGGGGGNASSVGSSVSGAYQ-----KAPLQRQEDV 1474

  Fly  1075 LEQTIQRKDKELSSITAKLEDEQVVVLKHQR------QIKELQARIEELEEEVEAERQARAKAEK 1133
            |::.::..|.|.:| .:..:|.::...:::|      .:|....|::.....|......      
Mosquito  1475 LDRPLRMYDIERAS-KSTFDDTELAKYRYERGGGVSSTVKLPVRRVDSGPSSVAGSGTG------ 1532

  Fly  1134 QRADLARELEELGERLEEAGGATSAQIELNKKREAEL-----SKLRRDLEEANIQHESTLANLRK 1193
                              :||:|..:..:.:.|..:.     |.:.|:...:|..:.::...:..
Mosquito  1533 ------------------SGGSTMGRPGIQRFRYGDTASYGGSGMIRNQNHSNNSYSNSNVEIVF 1579

  Fly  1194 KHN--DAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK------AAQEKIAKQ 1250
            .:.  |:|...|......:...:.|.:..|.     |.:.:|.  :|..:      ::..:.:..
Mosquito  1580 VNTGLDSVGAPAGSGGTGSLSSSPAARNLNR-----NSISSGT--LTQTQVPPSLASSMRRDSLP 1637

  Fly  1251 LQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ-------LSKIKISLT 1308
            |.|.|. .::..||.|   :::...:::..::.....:|.::.:.|..|       ||....|:.
Mosquito  1638 LSHHLG-TRTPGDEIN---SNYHMHQQQQQLQQQHQQQQQQQQQQQQQQHQHQQQPLSPSSSSVA 1698

  Fly  1309 TQLEDTKRLADEESRERATL--------LGKFRNLE-------------HD---LDNLREQVEEE 1349
            :..:.: :.....|....:|        :|.::||:             |.   .:|..:.|...
Mosquito  1699 SHHQQS-QTGSPMSHSPQSLPLVGSAGHIGNYQNLQFPPTSNYHQHHHHHQQSVYNNNAQPVSTG 1762

  Fly  1350 AE----------GKADLQRQLSKANAEAQVWRSKYESD---------------------GVARSE 1383
            |:          |........:.|:|.:|...:.|..|                     |.|:||
Mosquito  1763 AKMVTSTPYGAAGSNSSYATGASASASSQRVSAAYPDDFAQNYYTTTTTTPKGKAAALLGTAKSE 1827

  Fly  1384 E-------LEEAKRKL-QARLAEAEET-----------------------IESLN---QKCIGL- 1413
            :       |.::|..| :|.||:|:.:                       |:|.|   ::.:|. 
Mosquito  1828 DSAVTNAGLGQSKYPLDRATLAKADSSDMVLSAGNKSAINQGAGNASGRRIKSTNLSEEQLVGSS 1892

  Fly  1414 ------------------------------------EKTKQRLSTEVEDLQ-LEVDRANAIANAA 1441
                                                :..|:|.|.....:. |||:|.|.:..::
Mosquito  1893 GSSVSYHPGTGLTRRGPVGTSASGGSGNTSSTGVAGDTLKRRNSDPTNKIPLLEVNRGNDMYQSS 1957

  Fly  1442 EKKQKAFDKIIGEWKLKVDDL-AAELDASQKECRNYSTELFR---------LKGAYEEGQEQLE- 1495
            .:     ..|.|....||..: .||..|..:|..::..|.:|         .|.....|.:.|: 
Mosquito  1958 TR-----INIAGHQFRKVQRINKAERCACCQEIDSFVNEGYRCLDCKVLVHTKCIQNGGIKSLQC 2017

  Fly  1496 AVRRENKNL--------------ADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEA 1546
            ||.:.:|.:              :....|....||.|..:..:|...|:..:: .|::.:..:|.
Mosquito  2018 AVAKRSKRIRTGGAGGGSGGLGGSSSKHDKHHPIGGGSASGQKISSTREYTDS-TDKIISDAKEL 2081

  Fly  1547 EAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEAL 1611
            :...:....|:.:.:.:..: ..|:||..::...||:          |::.|......:..::.|
Mosquito  2082 QLMQDFITQKICKMESDCEK-PSEVDRVFKQALREFK----------DNLVAQYSVAHRQNSDVL 2135

  Fly  1612 RMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERR 1676
            .:|                              |:..:.:.:..:|.....::|....:|::..|
Mosquito  2136 NIK------------------------------YRDLIANFEQVIETTSGRKNDFPLTMGVNAFR 2170

  Fly  1677 ANALQNELEESRTLLEQADRGRRQAEQELADAHEQLN---------------EVS---------- 1716
              ...||...||. .|:....|::.::...|.|...|               |:.          
Mosquito  2171 --GFMNEFMNSRE-TEKPKTKRKKDKKRKHDDHTTFNGHTFQLTILNIATACEICQQFLLWPIER 2232

  Fly  1717 ---AQNASISAAKR---KLESELQTLHSDLDELLNE----------------------------- 1746
               .||..::..|:   |..|..:..::|.:.||..                             
Mosquito  2233 GLVCQNCKLTCHKKCYQKSASCNKIANADPNSLLGAGGSGSAVVAGGCGPDGQPLYGGGIPTKLF 2297

  Fly  1747 -------AKNSEEKAK-KAMVDAARLADELRAEQDHAQTQEKL--RKALEQQIKELQVRLDEAEA 1801
                   ..||.:..| .|.::...:..|:     |....|.:  :..:..:||:|:.::|.|..
Mosquito  2298 GVPLTALCGNSSDGVKIPAQINKLIMMIEM-----HGLYSEGIYRKSGVSSKIKDLKAKMDRAVT 2357

  Fly  1802 NALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKE--LSFQSEEDRKNHERMQ 1864
            :|..||               .|:|.|..........|:...|.:.|  |:|...:|......:.
Mosquito  2358 SADGGG---------------GEMDFESYNVHVLTNVLKSFLREMPEPLLTFDRYDDFLRAADLS 2407

  Fly  1865 DLVDKLQQKIKTYKR--------------------QIEEAEEIAALNLA-----------KFRKA 1898
            |..|::|..:...|:                    ::|:...::|.:||           ::..|
Mosquito  2408 DGSDRVQTLLSLVKKIPPAHHCLFERLIFHLALVAKLEQYNRMSASSLAIVFAPCVLRTNRYVPA 2472

  Fly  1899 QQELEEAEERADLAEQAISK 1918
            |..|.:...:....|..|::
Mosquito  2473 QDSLNDIGRQTKCMETLITQ 2492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 12/44 (27%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 255/969 (26%)
Myosin_tail_1 842..1922 CDD:460256 218/1404 (16%)
LOC1278822XP_061507801.1 None

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