DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and didum

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_061498899.1 Gene:didum / 1277086 VectorBaseID:AGAMI1_009889 Length:1868 Species:Anopheles gambiae


Alignment Length:2089 Identity:566/2089 - (27%)
Similarity:898/2089 - (42%) Gaps:476/2089 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEK---EGYLLG-EIKATKGDIVSVGLQGGE-TRDLK--KDLLQQVNPPKYEKAEDMSNLTY 96
            |||..:   ||.::. :.|.....:..|..:|.| |..||  .||....||.......|::.|:|
Mosquito    14 WIPHPETVWEGAVVAQDYKQDDKQLKLVTDRGVEHTVPLKTPADLPPLRNPTILIGQNDLTALSY 78

  Fly    97 LNDASVLHNLRQRYYNK-LIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160
            |::..||:||..|:.:: .||||.|:..||||||...|:|.....:.|||....|:.|||||:|:
Mosquito    79 LHEPDVLYNLEVRFCDRQAIYTYCGIVLVAINPYAELPLYGPDLIRAYRGHAMGELEPHIFAVSE 143

  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225
            .||..:.....:.|::::||||||||.:.|..:.|||.||.|       :|:..:|.:|:.::|:
Mosquito   144 EAYAKLEREKCDISIIVSGESGAGKTVSAKYAMRYFAAVGGS-------ESETQIEKKVLASSPI 201

  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHF--GPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQI 288
            :||.|||||.|||||||||||.::.|  ..:..|.|..::||||||:||..|...||:||||||:
Mosquito   202 MEAIGNAKTTRNDNSSRFGKFTKLLFLNNHSMALTGGTMQTYLLEKSRVCFQAPGERNYHIFYQL 266

  Fly   289 MSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRIT 352
            .:|.....:   |:.|:...:|.::||: ..::.:.|.::|..|..|...|||...|..|:.::.
Mosquito   267 CAGREQWPE---LMLDHQDKFHFLNQGQSPNISKLSDRDQFEDTLGALKTLGFDDAEIGDIMKVV 328

  Fly   353 AAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKL---FGC-----DTAELYKNLLKPRIKVGNEF 409
            |:|:|:|.:.|..|.:.:.:|.|.|......:.|   ..|     |..||.|.|:..:|:..|:.
Mosquito   329 ASVLHLGNVVFNHRQKSQTSEVDSEACSIASNDLHLNVACDILQLDRGELRKWLVTRQIESMNDS 393

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQH--FIGVLDIAGFEIFEYNGF 472
            |....|.|....:..||.|.::..||:.:|:|.|..| ...|:|:  |||||||.|||.|:.|.|
Mosquito   394 VLIPMNKQTAEATRDALAKHIYAELFQHIVQKINRNL-AGSKKQNCCFIGVLDIYGFETFDINSF 457

  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEES 537
            ||.|||:.||||||.||.|:|.||||:|.||||||..||| .|.|.||||||..:|||.:|:||.
Mosquito   458 EQFCINYANEKLQQQFNQHVFKLEQEQYLREGIEWKMIDF-YDNQPCIDLIESKLGILDLLDEEC 521

  Fly   538 MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLN 602
            ..|:.:|.::..||.. ..||...|.:   |:.|..|  |.|.|::..|.|...|:||||:|.::
Mosquito   522 RMPRGSDDSWVGKLME-KCGKYPHFDR---PRFGTSA--FLIKHFSDTVQYESRGFLEKNRDTVS 580

  Fly   603 DTVVDQFKKSQNKLLIEIFADHAGQSGGGE------QAKGGR-----------GKKGGGFA---- 646
            ..:|...|.|..:|...:..  |.:.|||:      .|.|.:           .||.....    
Mosquito   581 RELVSVLKASGMRLCQRLMV--AQEEGGGDGDAKTAPAAGVKIMVSAARTQSVDKKKKPMTQKQQ 643

  Fly   647 --TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKG 709
              ||.|.::|.|..|:|||.:|.||:||||.||:.|.|...:|..::.||...||||.:||...|
Mosquito   644 RKTVGSQFRESLTQLITTLHNTTPHYVRCIKPNDDKAPFKWEAPKIVQQLRACGVLETVRISAAG 708

  Fly   710 FPNRMMYPDFKMRYKIMCPKLLQGVEKDKKA--TEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            ||:|..|.||..||:::| |..|.|:...||  |.|:..:: |.||:||||||::|||||.:..:
Mosquito   709 FPSRWKYEDFYERYRLLC-KRAQIVDWHVKATCTNIVRNWL-LDEDKYRLGNTQIFFRAGQVAYL 771

  Fly   773 EEFRDE-----------------------RLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ 814
            |:.|.:                       ||.:....:|..|||.|:||....|::.|.|: ::|
Mosquito   772 EQVRSDTRKKHIIVVQSLIRRFVCRRRYLRLKQTALGLQRHARGMLARKRADNLRKNRAAI-IIQ 835

  Fly   815 RNLR------KYLQLRTWPWYKLWQKVKPLLNV-SRIEDEIARLEEKAKKAEELHAAEVKVRKEL 872
            |..|      :|:|:||           .:|.: :|....:||  .|.:.|.:.:.|     .|:
Mosquito   836 RYTRGWLQRKRYVQIRT-----------AVLGLQTRARGFMAR--RKFRAALDNYKA-----TEV 882

  Fly   873 EALNAKLLAEK--TALLDSLSGEKGALQDYQERNA--KLTAQK----------NDLENQLRDIQE 923
            :......||.:  .|.||.:...:.|::.:..|.|  ||.|:.          ..|||::.::|:
Mosquito   883 QRFCRGYLARRRYRARLDHIIKCQAAVRRFLARRAFKKLKAEARTVAHIQKMYKGLENKIIELQQ 947

  Fly   924 R---LTQEEDARNQLFQQKKKADQEISGLKK---DIEDLELN-VQKAEQDKATKDHQIRNLNDEI 981
            |   |::|..|..:...:..:..|::.|:|:   :::.|:|. |||.|:...:    ||.|..| 
Mosquito   948 RHDVLSKENAALKKQNVEVVEMRQKLDGMKRLEGELKLLQLQLVQKDEKLMLS----IRQLEGE- 1007

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
                       :::|||....::..||.:|.|                    .|:.|:|      
Mosquito  1008 -----------RDEKMQLLEEKQREEEERARE--------------------RDAFEQE------ 1035

  Fly  1047 VEKSKRKVEGDLKLTQEAVADL--ERNKKELEQTIQR--KDKELSSITAKLEDEQVVVLKHQRQI 1107
            :.|.:|:|.....:||...|.|  :.:.:|:....||  |||::      ||:|.|.:.:..|::
Mosquito  1036 LAKVRREVTEITAVTQIEQARLVSQADTEEIHAAYQRTVKDKDV------LENENVALRQEVRRL 1094

  Fly  1108 KELQARIEELEEEVEAERQARAKAE--------KQRADLARELEELGERLEEAGGATSAQIELNK 1164
            :.:.|...||:....:...|.:..|        :...|:.|......|  .:||||.........
Mosquito  1095 QRIMADSHELKTHSRSVSNASSTNEEDYGYTSGRNTLDIRRASPHPYE--GDAGGAGGGSAGRGS 1157

  Fly  1165 KREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLND 1229
            .|....|      ..:|....||:          ||...|         ::.|::::.:......
Mosquito  1158 HRSGGGS------VGSNYSVSSTI----------VASHGE---------SRREEKRHPFVDYERV 1197

  Fly  1230 LRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETN---RTLNDFDASKKKLSIENSDLLRQLE 1291
            .|...|.|...|...:.       |:.|...| |:|.   |....|:..|.|     |:.||:  
Mosquito  1198 YRTPPDAIGMLKDPSDS-------TVGESPEK-DQTAIILRMRKLFEEEKSK-----SEQLRK-- 1247

  Fly  1292 EAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADL 1356
                   :|:::|.|.|...||:.|.::               ||.:.:.||:..        :|
Mosquito  1248 -------ELARLKKSSTFSTEDSIRASE---------------LEVENEKLRQDY--------NL 1282

  Fly  1357 QRQLSKANAEAQVWRSKYESDGVARSEELEEAKRK---LQARLAEAEETIESLNQKCIGLEKTKQ 1418
            .|...|...|::...::|.    |..|||:..:.:   |:|.||:..:::.||.|...|.| |..
Mosquito  1283 LRNSIKRGVESREMDAQYG----ALQEELKRRREECISLKAVLAQQSQSLRSLGQTANGAE-TSL 1342

  Fly  1419 RLSTEVE-----------DLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAA-------- 1464
            |:..|.|           :.||| ....||.:|..:.....::||...:.:..:|.|        
Mosquito  1343 RIHDEGELMEAFQAQKLVNRQLE-SELRAITDANNETLVENNRIIDGLRTENGELQAILQQHVEQ 1406

  Fly  1465 -----ELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHE 1524
                 :|:..::..:....||.:...||.|.||||..:..:|..|..:...|.:::.:.|.|...
Mosquito  1407 VGEEVDLETVRQNEQYLRHELRKSTAAYVELQEQLNELLAKNNELLKKNNILSNRLRDHGLNDSI 1471

  Fly  1525 IEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ----VRQEIDRRIQEK------- 1578
            :         ..||..:.:            .|::.|.:.||    .|||.:.:|.::       
Mosquito  1472 L---------MNDEFHSMV------------AVVKKQTQSSQGILKYRQEDESKIMQRLVTDLKP 1515

  Fly  1579 ------------EEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIAL--- 1628
                        ...|...|......:|.:..||      ....::|.|:|....|.:|:.:   
Mosquito  1516 RVAVTLAPSLPAYVVFMCIRYTDLVNMDQLVRSL------LTRFVQMIKRLYRGANSVEVRVMWL 1574

  Fly  1629 -----------------DH----ANKANAEAQKN---------------------IKRYQQQLKD 1651
                             |:    .:..||:..||                     |::.|..||.
Mosquito  1575 ANTLTLHNLMKQFGGYKDYMKYNTDVQNAQQLKNFDLAEYRQVIHETIISMHSVLIRQVQDSLKQ 1639

  Fly  1652 --IQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAE---QELADAHEQ 1711
              :...|..::.||..:|..:.:.                  ...::||.:.|   |:|...:..
Mosquito  1640 YIVPAILHHDETARGKSRRTMSLD------------------ISPEQGRSEPELLVQQLGCVYNH 1686

  Fly  1712 LNEVSAQNASISAAKRKLESEL-------QTLHSD----------------LDELLNEAKNSEEK 1753
            |:....:...|....::|...:       ..|..|                ||:.:.:.|...: 
Mosquito  1687 LSSFGLEGCYIEQIFKQLMHYICAVSVNNLMLRGDLCMWKTGMKLRYNMGCLDDWVRKMKMGPD- 1750

  Fly  1754 AKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRV 1818
            ..|..:...:::..|:|.    :|:|.:...|     ||...|..|:.      .|.|:  ..:.
Mosquito  1751 VMKPFLPLNQISSILQAR----KTEEDVHTLL-----ELSTALSTAQV------LKIIK--SYKT 1798

  Fly  1819 RELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEE 1883
            .:.||::..........|.||| ||:|..:.....||          ||..|....|..:..:||
Mosquito  1799 DDCENQIRPAFIEKLTQQLNLR-SEQRESDTYMMDEE----------LVSPLVVLFKYSEINLEE 1852

  Fly  1884 AEEIAALNL 1892
            .:....|||
Mosquito  1853 IDLPPELNL 1861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 12/42 (29%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 280/703 (40%)
Myosin_tail_1 842..1922 CDD:460256 240/1210 (20%)
didumXP_061498899.1 None

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