DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and AgaP_AGAP011138

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_564385.3 Gene:AgaP_AGAP011138 / 1270789 VectorBaseID:AGAP011138 Length:1909 Species:Anopheles gambiae


Alignment Length:1846 Identity:434/1846 - (23%)
Similarity:740/1846 - (40%) Gaps:492/1846 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 GEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKR 131
            ||...|..:.:|..||...:.:||:..:..||...|||.||||:...||:|.:|...:.:||...
Mosquito   295 GEELLIDEDDLEVANPATLDLVEDVCQLPHLNESSVLHVLRQRFANNLIHTRAGPVLLIVNPMAP 359

  Fly   132 YPVYTNRCAKMYRG-KRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAY 195
            ..:|:.:.|.|:|| |..:::||||||.:..||..||....:||::..|.||||||.:.|..: |
Mosquito   360 LALYSEKVASMFRGCKAEDDMPPHIFAQAQTAYRAMLETRRDQSLIFLGRSGAGKTTSFKHAL-Y 423

  Fly   196 FATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            :.|: ||:...:.|..:....::|.....:|:||||.:|..|.|:::|.:...:.|..:|::...
Mosquito   424 YLTL-ASRPEVQPAVQRALTVEKVSAIGTILDAFGNERTALNGNATKFTQIFALDFDHSGQIVSG 487

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGV--KDICLLTDNIYDYHIVSQGKVTVASID 323
            .|:...:::.|.....:...:....:..::|...|.  |:: ||.....|......|.|...|||
Mosquito   488 SIQIMPIDRMRPAGGSNRGTAGVPRWSFLAGVDGGALRKEL-LLEPVAGDASAGGNGTVEQESID 551

  Fly   324 DAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHM---------GGMKFKQRGREEQAEQDGEEE 379
                :....|||.:|...:.....::.:.||:.|:         |.::|......::|       
Mosquito   552 ----YQRLCQAFRVLNIDQGAVRGIWYVLAAIHHLSQSGAVIVAGRVQFVNPRAAQKA------- 605

  Fly   380 GGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIG--ALCKGVFDRLFKWLVKKC 442
                :.|.|....:|...:. |....|.   |...::...|.:.|  |..:.::..||..||...
Mosquito   606 ----AMLLGIPMEDLLSYVF-PETGSGG---TSKASLSTATVAEGLTAFTEALYTELFYTLVGLI 662

  Fly   443 NETLDTQQKRQHFIGVL--DIAGFEIFEYNG-------FEQLCINFTNEKLQQFFNHHMFVLEQE 498
            |:::......|....||  |:.||:.....|       ...|..|:.:|:||..|::.|.|..:.
Mosquito   663 NKSIAAVTPHQTIGSVLLVDVPGFQNPASVGGGTAASTLADLRFNYLHERLQLLFHNAMLVQPRA 727

  Fly   499 EYKREGIDWAFIDFGMDLL-------------ACIDLIEK-PM------GILSILEEES------ 537
            .|.:|.:.   ::..:.|:             |.:.|::| |.      |:|.:|:||.      
Mosquito   728 RYAQEMVT---VEDSLALMATDSAGSGHSSPAAMVALLDKVPQSHEPRKGLLWMLDEEQLLNPVG 789

  Fly   538 ----------MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGC--VSYNI 590
                      :|....|:...|.|.   |..|.|          ..|....:.|..|.  |.|::
Mosquito   790 MAKGGDSNARLFAAYGDRETRETLL---LRASVP----------TGACDVVLQHLLGTNPVLYSV 841

  Fly   591 TGWL-----------EKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGG--EQAKGGRGKK- 641
            |.||           ::..:.|.|:|    |...|.|.:       |..||.  ..|.||.|.. 
Mosquito   842 TSWLREAAAQAHYMPQRALNCLRDSV----KPEINGLFV-------GTLGGAMDSLAFGGGGSSQ 895

  Fly   642 ------------------GGGFATVSSA---YKEQLNSLMTTLRSTQPHFVRCIIP--------- 676
                              |.||...:|.   .|..::.|:.|||.|..|||.|.:|         
Mosquito   896 QLQQQSLRRMSSIRRTYTGTGFPKRNSVIVQVKYTVDCLIDTLRRTGMHFVYCYLPQHNGGTAMA 960

  Fly   677 ------------------NEMK----QPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF 719
                              :||.    :..:::..|:..||..:.:|:..|:.|.|||..:...:|
Mosquito   961 MTGCLFDQQQQQHHHQLTHEMNGRRAEDDIINIPLLRSQLRGSQMLDFARLYRLGFPISVPLGEF 1025

  Fly   720 KMRYKIMCPKLLQGV------------------EKDK----------------KATEIIIKFIDL 750
            .:|:.::......|.                  |.:|                |..|.::...:.
Mosquito  1026 VIRFGLLAEGGTTGSDWSEDSGRMSNENLDLFGEPEKPNGSSAAVAAAAPLPGKLNESLLGIFEN 1090

  Fly   751 PEDQYRLGN------------------------------TKVFFRAGVLGQMEEFRDERLGKIMS 785
            .:.|....|                              ::||||:||||.:|..||:.|...:.
Mosquito  1091 AQSQTTTTNLESVPSTFLIVAVIRPLNVSICFFFFSPLISQVFFRSGVLGALEAKRDDLLSDRVI 1155

  Fly   786 WMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR 850
            .:||..||||:|:...:.:.|.:|:|.:|||:|.:|::|.|||::|..:|.|||.|.|.|     
Mosquito  1156 QLQAHCRGYLARRRLARRRLQELAVKCIQRNVRAFLKVRDWPWWRLLVRVTPLLAVHRTE----- 1215

  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE 915
                    |:|.||.|    ||:.:.|||  ||   ::|            ||| :|.|..:.||
Mosquito  1216 --------EQLKAATV----ELQQVRAKL--EK---IES------------ERN-ELKATNHKLE 1250

  Fly   916 NQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE 980
            .:|.||...|.:|..:.|.:.::......|...|:|::::.|                       
Mosquito  1251 ARLSDITSELAEEHSSSNLITERLAAETSERLRLEKEVKEYE----------------------- 1292

  Fly   981 IAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRG 1045
                       :|.:.:| |:::|...||..|:.::|             .:.:|.         
Mosquito  1293 -----------SKYRHLQ-ESSEKMEMELLCAKSELN-------------CDFDDC--------- 1323

  Fly  1046 DVEKSKRKVEGDLKLTQEAVA-DLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKE 1109
                   ...||.:|..|.|| :||..||.| ||....|.           ||:|.||     |:
Mosquito  1324 -------STLGDYRLRYERVARELEFTKKRL-QTQHEHDL-----------EQLVGLK-----KQ 1364

  Fly  1110 LQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLR 1174
            |:.::.:..||||.:||..|:.:::...:..|:.:|....||.....:...:..:|.:||.    
Mosquito  1365 LEKKLADAYEEVEEQRQVVAQWKRKAQKMTNEMNDLRMLYEEQNSRNNLLEKRQRKFDAEC---- 1425

  Fly  1175 RDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITN 1239
                       .||.:..::...|...||.:.|.|...|.|.|:       .::|:|..::    
Mosquito  1426 -----------QTLQDSARQERQAKERMAREKDVLMAEKCKLEQ-------TVSDIRLELE---- 1468

  Fly  1240 EKAAQEKIAKQLQHTLNEV------QSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVS 1298
              ..:||:. .||..|:|:      :.::.:..|..|:.|...|:..       .:|:|...|:.
Mosquito  1469 --LKEEKVT-ALQQELDEMAFGGGTEEEIAQLKRQKNELDRRCKEQD-------EELDEMAGQIQ 1523

  Fly  1299 QLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEH-DLDNLREQVEEEAE-------GKAD 1355
            .|.:.|:.|...||.:::.|.:|:::|...:.:.|...: .:.:|..|:|:|.|       .|.:
Mosquito  1524 LLEQAKLRLEMSLETSRKEARKEAQQRDDEMEEIRGASYKKIKSLECQLEQEHEERTQLLRDKHE 1588

  Fly  1356 LQRQLS---------KANAEAQVWRSKYESDGVAR---------SEELEEAK---------RKLQ 1393
            |:|:|:         :|..||.|.|.|.:    ||         ..:|:.||         |:|:
Mosquito  1589 LERKLASLEDQDRAERAAEEAMVQRLKRD----ARKYRALLRDAQSQLDRAKGDSASKALVRQLR 1649

  Fly  1394 ARLAEAEET-IESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKL 1457
            .:|.:||.. :.:|        |.:|.|..|::|.||..:......|.||.:.....:...|.:.
Mosquito  1650 NQLEDAESARVAAL--------KARQVLEGELQDAQLLFEETQRARNEAEDRATVAQRDRAELQA 1706

  Fly  1458 KVDDLAAELDASQKECRNYSTELFRLK------GAYEEGQEQLEAVRRENKNLADEVKDL----- 1511
            ::|:...|:....|:   ||..:.:|.      ..||....:||.   |.|:|.::|.:|     
Mosquito  1707 QIDENEEEMAELMKK---YSATVKQLSSEQSLIAEYELRVSELEG---EKKSLKEQVVELATRLE 1765

  Fly  1512 -LDQIGEGGRNIHEIEKARKRLEAEKDELQAALE-------EAEAALEQEENKVLRAQLELSQVR 1568
             ::.|||...::     |.||||....||::.||       ..|..|.:.::.:.:.|.||||.|
Mosquito  1766 SVETIGEPSNSM-----AFKRLELRTKELESRLEFEQATRARIEIQLARHKDSLEKLQGELSQAR 1825

  Fly  1569 QEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANK 1633
                    .:|.:.::..|..|:.:..::..|...|....|.| :|:|      |||..::.|..
Mosquito  1826 --------NREAQAQDALKKGQKTVRELRDELSTLANRDQEGL-LKRK------ELEKRIETAES 1875

  Fly  1634 ANAEAQKNIKRYQQQLKDIQTALEEE 1659
            ..|.|:.:::...|::.|:|.|:|||
Mosquito  1876 ETASARADLRLALQRIADLQQAMEEE 1901

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 2/5 (40%)
MYSc 81..777 CDD:214580 198/886 (22%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 185/855 (22%)
Myosin_tail_1 842..1897 CDD:279860 204/880 (23%)
V_Alix_like 1557..1877 CDD:187408 28/103 (27%)
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
AgaP_AGAP011138XP_564385.3 PDZ_signaling 89..189 CDD:238492
MYSc 309..1033 CDD:214580 182/772 (24%)
Motor_domain 328..1057 CDD:277568 177/777 (23%)
Tropomyosin 1214..1482 CDD:278679 91/412 (22%)
Uso1_p115_C 1230..>1309 CDD:282695 27/131 (21%)
TPH 1363..1726 CDD:290579 92/413 (22%)
PRK13923 1440..1608 CDD:276343 41/188 (22%)
TPH 1553..1900 CDD:290579 92/384 (24%)
Ax_dynein_light <1727..1807 CDD:287215 23/87 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.