DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and AgaP_AGAP007523

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_308355.3 Gene:AgaP_AGAP007523 / 1269708 VectorBaseID:AGAP007523 Length:2003 Species:Anopheles gambiae


Alignment Length:1996 Identity:756/1996 - (37%)
Similarity:1204/1996 - (60%) Gaps:80/1996 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DEDPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL--QGGEV 69
            |.:.....::|:|:...:.   ...:..|:..|:|.|.:|::...||..:||.|.|.|  .|..|
Mosquito     7 DRNDPELKYLSVERNSFNDPATQAEWTQKRLVWVPHESQGFVAASIKGERGDEVEVELAETGKRV 71

  Fly    70 RDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPV 134
            ..:|.: ::|:|||||:|:||||::|.||...||||::.|||:.|||||||||||.:||||:.|:
Mosquito    72 LVLKDD-IQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPI 135

  Fly   135 YTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV 199
            ||.:..:.|:|.:|:|||||:|||:|.||..||.:..:||:|.||||||||||||||||.|.|.|
Mosquito   136 YTEKIMEKYKGIKRHEVPPHVFAITDTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAYV 200

  Fly   200 GASKKTD----------------------------EAAKS----------------KGSLEDQVV 220
            .|||...                            ||:.|                ||.||.|::
Mosquito   201 AASKPKGSVAVGVGCSLYFPWRSRNKHVQPCIDCWEASNSLAEGLSALREMRLLWGKGELEQQLL 265

  Fly   221 QTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIF 285
            |.||:||||||||||:|||||||||||||:|..:|.::||:||||||||:|.|.|...||::|||
Mosquito   266 QANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGYISGANIETYLLEKSRAIRQAKDERTFHIF 330

  Fly   286 YQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            ||:::|:.|..::..:| |::..|..:|.|.:.|..:||..||..|.::.:|:|.|.::...::|
Mosquito   331 YQLLAGASPEQRERFIL-DDVKTYPFLSNGGLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFR 394

  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 415
            |.:||:..|.|.|||....:||.........:::.|.|.:..::.|..|.||||||.:|||:.:.
Mosquito   395 IVSAVLLFGSMTFKQERNSDQATLPDNTVAQKIAHLLGLNVTDMTKAFLTPRIKVGRDFVTKAQT 459

  Fly   416 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINF 479
            .:||..::.|:.|..::::|||||.:.|.:|| |:::...|||:||:|||||||.|.|||||||:
Mosquito   460 REQVEFAVEAIAKACYEKMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINY 524

  Fly   480 TNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATD 544
            |||||||.|||.||:||||||:||||:|.|||||:||...||||:||.||:::|:||..||||||
Mosquito   525 TNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATD 589

  Fly   545 QTFSEKLTNTHLGKSAPFQKPKPPKPG-QQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608
            ::|.|||...|      ...||..|.. :..|.||:.||||.|.|:.|.||.||.||||:.||..
Mosquito   590 KSFVEKLAAAH------SMHPKFMKTDFRGVADFAVVHYAGKVDYSATKWLMKNMDPLNENVVSL 648

  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAK-----GGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQP 668
            .:.||:..:::|:.| |...|..:||.     |.|.:| |.|.|||..|||||..||.|||:|.|
Mosquito   649 LQASQDPFVVQIWKD-AEIVGMAQQALTDTQFGARTRK-GMFRTVSHLYKEQLAKLMDTLRNTNP 711

  Fly   669 HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-Q 732
            :||||||||..|:.|.:||.||:.||.||||||||||||:|||||:.:.:|:.||:::.|.:: :
Mosquito   712 NFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK 776

  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797
            |....|:|.|.:||.::|..:.||:|.:|:|||||||..:||.||.::..::...||:.||:|:|
Mosquito   777 GFMDGKRACEQMIKSLELDSNLYRIGQSKIFFRAGVLAHLEEERDYKITDLIVNFQAFCRGFLAR 841

  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862
            :.::|..:|..|::::|||...||:||.|.|::|:.||||||.|::.|:::.:.|::.::..:..
Mosquito   842 RNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELRQIRDKL 906

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927
            ....|..:|.|....:.:.|||.|.:.|..|.....:.:|..|:|.|:|.:||..::|::.|:.:
Mosquito   907 ENLSKNSQEYEKKYQQAMEEKTHLAEQLQAEIELCAEAEEGRARLVARKQELEELMQDLESRIEE 971

  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLN 992
            ||:..|.|..:|||....|..|::.:|:.|...||.:.:|...|.:::.:.:::|..::..:||.
Mosquito   972 EEERVNALTSEKKKLQINIQDLEEQLEEEEAARQKLQLEKVQLDAKLKKMEEDVALIEDQNHKLV 1036

  Fly   993 KEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGD 1057
            ||||:..|......:.|...|:|..||.|:|.|.|.|:.|||:.|.::.:.|.:.::||||:|.:
Mosquito  1037 KEKKLLEERANDLSQTLAEEEEKAKHLAKLKVKHESTIAELEERLLKDHQQRQEADRSKRKIETE 1101

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVE 1122
            :...:|.:.:.....:|::|.:.::::||:....::::|.......|:..:||::::.|::|::|
Mosquito  1102 VADLKEQINERRMQIEEMQQQLVKREEELAQTLVRIDEESAAKAAAQKTQRELESQLAEIQEDLE 1166

  Fly  1123 AERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHEST 1187
            ||:.||:|||||:.||..|||.|...|.::...|:||.||..|||.|::.|::.||:.:..||||
Mosquito  1167 AEKLARSKAEKQKRDLNEELEALKNELLDSLDTTAAQQELRSKREQEVATLKKTLEDESANHEST 1231

  Fly  1188 LANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ 1252
            |.::|.||...::.:.||::.|.|:|...||.|.:...:..||...:.::...:...::..||.:
Mosquito  1232 LMDMRHKHAQEISSINEQLENLKKMKGGLEKSKQQLEAENADLATELRNVNQSRQENDRRRKQAE 1296

  Fly  1253 HTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRL 1317
            ..:.|:|.||.:.:|...:......||..|:.::.:||:|||.:.|...|...:|.:||.:.::|
Mosquito  1297 TQIAELQVKLADVDRVRVELQDKVTKLQQESENITQQLDEAELKASAAIKSAGNLESQLTEAQQL 1361

  Fly  1318 ADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDG-VAR 1381
            .:||:|::..|..|.|.:|.:.:.|:||:||:.|.|.:.:::|::.|...|..:.:.|.|. :|:
Mosquito  1362 LEEETRQKLALSSKLRQIESEKEALQEQLEEDEEAKTNYEKKLAELNFTIQEMKKRSEEDSDIAK 1426

  Fly  1382 SEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446
              ||||:|:|:...:...:..|:.|......|:|:|:::.:|:||..:|:|.........|||||
Mosquito  1427 --ELEESKKKMNKDIETLQRQIQELQAANDRLDKSKKKIQSELEDATIELDTQRTKVLELEKKQK 1489

  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511
            .|||::.|.|...:.:|.|.||:::|.|...|::..|....:|..|:::.:..:.|.|.:|:.:|
Mosquito  1490 NFDKVLAEEKAISEQVAQERDAAEREAREKETKVLSLTRELDEAFEKIDELETKRKGLQNELDEL 1554

  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576
            .:..|...:|:||:|||::.||::..||:|..||.|..|:..|:..||.::.:..:|.:.:|.||
Mosquito  1555 ANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRAQFERDIQ 1619

  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641
            .|||:.|..|:...:||..::|.|:.|.|.:|.|:..|||||.|:.::|..|:..||...:|.|.
Mosquito  1620 AKEEQSEEKRRGLVKALRDLEAELDEERKQRAAAVAAKKKLEGDLKDMEATLEMNNKVKEDALKQ 1684

  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELA 1706
            .|:.|.|:||.....||.:.|:::.......|||:...|:.:|.:....|..::|.||.||.|..
Mosquito  1685 AKKLQAQIKDAIRDAEEAKAAKEELAAISKESERKVKTLEADLMQLTEDLSSSERARRAAEGERD 1749

  Fly  1707 DAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLADEL 1768
            :..|::|..|::.:.:...||:||:.:..|..:|:|   |..|.|   ::.:||.:...:|..||
Mosquito  1750 ELLEEINSNSSKGSLMIDEKRRLEARIAALEEELEE---EQSNLELMVDRNRKAQLTIEQLTTEL 1811

  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            ..|:.::|..|.|:..||:..|||:.:|.|.|.......|.|....|.:...||.:|:.|.:...
Mosquito  1812 ATEKSNSQNNETLKCGLERLNKELKAKLSEQETALRTKLKAATAASEAKNLNLEKQLENETKERL 1876

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898
            ..||..||.|:|:|||:...|::|::.::.::.::|...::||.||.::||||.........|||
Mosquito  1877 AVQKANRKLEKRIKELTMNIEDERRHADQYKEQIEKANNRMKTLKRNLDEAEEEIQKEKTLKRKA 1941

  Fly  1899 QQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRPQ 1944
            |:|.|:..|..:...:.::..::|.|.|    ||..:..:|.:.|:
Mosquito  1942 QRECEDMLESHEALSREVNALKSKLRRG----GAMGSLSSTRLTPK 1983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 13/38 (34%)
MYSc 81..777 CDD:214580 368/747 (49%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 347/716 (48%)
Myosin_tail_1 842..1897 CDD:279860 327/1058 (31%)
V_Alix_like 1557..1877 CDD:187408 101/322 (31%)
ATP-synt_B <1671..1771 CDD:304375 30/102 (29%)
TMPIT 1739..>1825 CDD:285135 27/88 (31%)
AgaP_AGAP007523XP_308355.3 Myosin_N 36..73 CDD:280832 13/36 (36%)
Myosin_head 89..809 CDD:278492 354/728 (49%)
MYSc_Myh2_insects_mollusks 101..809 CDD:276876 347/716 (48%)
Myosin_tail_1 886..1966 CDD:279860 334/1084 (31%)
RILP-like <1525..1624 CDD:304877 32/98 (33%)
GBP_C <1832..1963 CDD:303769 40/130 (31%)
coiled coil 1931..1943 CDD:293879 3/11 (27%)
coiled coil 1952..1963 CDD:293879 0/10 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
TreeFam 00.000 Not matched by this tool.
43.920

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