Protein Alignment Mhc and Myo1b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_038938878.1
• Gene: Myo1b / 117057
• RGDID: 70994
• Length: 1147
• Species: Rattus norvegicus
• Alignment Length: 1145
• Identity: 342/1145 - (29%)
• Similarity: 533/1145 - (46%)
• Gaps: 190/1145 - (16%)

  Fly    97 LNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDG 161
            ||:.:.:.||::|:.:..||||.|...:::|||:..|:|:....:.||.:...|:.|||||:||.
  Rat    26 LNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDE 90

  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSKGSLEDQVVQTNPV 225
            ||..:.....:|.:||||||||||||.:|.|::|.|.| |...:.::       :::|::|:.||
  Rat    91 AYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQ-------VKEQLLQSTPV 148

  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290
            ||||||||||||||||||||::.|.|...|...|..|..|||||:||:.|...||::|:|||::|
  Rat   149 LEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLS 213

  Fly   291 GSVP-------GVKDICL----LTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQE 344
            |:..       |..:..|    |..:...|:.:|.....|..:|||..|.....|..|:||:..|
  Rat   214 GASEELLRKSMGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFSDPE 278

  Fly   345 KEDVYRITAAVMHMGGMKFK----QRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            .|.|..:.|||:.:|.::||    ..|.:|...:| :.|...:.:|...|...|.:......::.
  Rat   279 AESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKD-KNELKEICELTSIDQVVLERAFSFRTVEA 342

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK-RQHFIGVLDIAGFEIFEY 469
            ..|.|:...||.|...:..||.|.::.|||.|||.:.||::..|.| |:..:|||||.||||||.
  Rat   343 KQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFED 407

  Fly   470 NGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSIL 533
            |.|||..||:.||||||.|.......|||||.||.||||.||:..:..:| |||| ...|||::|
  Rat   408 NSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIIC-DLIENNTNGILAML 471

  Fly   534 EEESMFP-KATDQTFSEKLTN---THLGKSAPFQKPKPPKPGQQAAH--FAIAHYAGCVSYNITG 592
            :||.:.| ..||:||.|||..   ||....:...|...........|  |.|.||||.|.|.:.|
  Rat   472 DEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEG 536

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLN 657
            :::||.|.|...:.....|:.:.|:..:|.:       |..||....:.    .|..|.:|..:.
  Rat   537 FVDKNNDLLYRDLSQAMWKAGHALIKSLFPE-------GNPAKVNLKRP----PTAGSQFKASVA 590

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            :||..|::..|:::|||.||:.|...:....||.||:...|:||.:|:.|.|:..|..|.....|
  Rat   591 TLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLER 655

  Fly   723 YKIMCPKL---LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQMEEFRDERLGKI 783
            ||::|.:.   .:|  ..:...|::...:::|.::|..|.:|:|.| ...|.|:|:.|.:||..:
  Rat   656 YKMLCKQTWPHWKG--PARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDL 718

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL---RKYLQ-----------LRTWPWYKL--- 831
            .:.:|...||:..|..|..::..:|.:....|..   ::|.|           :|.|...|:
  Rat   719 ATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRE 783

  Fly   832 -----------------WQKVKPLLNVSRIED----------------------EIARLEEKAKK 857
                             |...:......|::|                      |:.||:|:|::
  Rat   784 LKHQKRCKEAATTIAAYWHGTQARKERRRLKDEARNKHAIAVIWAFWLGSKARRELKRLKEEARR 848

  Fly   858 AEELHAAEV--------KVRKE-----------------LEALNAKLLAEKTALLDSLS------ 891
            .   ||..|        |||:|                 |:.:..|.|.|....:.|||
  Rat   849 K---HAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNW 910

  Fly   892 -GEKGALQDYQERNAK----LTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKK 951
             .......|...:..|    |...|. ..:|..|.|:.:.:|:...::||:.||.......|...
  Rat   911 PSRPYLFLDSTHKELKRIFHLWRCKK-YRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPF 974

  Fly   952 DIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQ---DELINKLNKEKKMQGETNQK----TGEEL 1009
            ....||:|          |:.:.:.|.|.|..:   .|::||:|   :..|::..:    |...|
  Rat   975 QGAYLEIN----------KNPKYKKLKDAIEEKIIIAEVVNKIN---RANGKSTSRIFLLTNNNL 1026

  Fly  1010 QAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD-------VEKSKRKVEGDLKLTQEAVAD 1067
            ..|:.|   ..::|:::     .|.|..:.....:.|       .|.|:...:||...:.:.:.:
  Rat  1027 LLADQK---SGQIKSEV-----PLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIE 1083

  Fly  1068 LERN--KKELEQTIQRKDKELSSITAKLEDEQVVVLKHQR 1105
            :...  :..|.||.|:.:.|:|       ||.:|..:..:
  Rat  1084 MATKLYRTTLSQTKQKLNIEIS-------DEFLVQFRQDK 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	253/691 (37%)
		Myosin_tail_1	842..1922	CDD:460256	67/338 (20%)
Myo1b	XP_038938878.1	MYSc_Myo1	29..699	CDD:276829	253/691 (37%)
		IQ	760..782	CDD:197470	4/21 (19%)
		Myosin_TH1	952..1129	CDD:461801	38/193 (20%)