DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and LOC108190403

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_021327440.1 Gene:LOC108190403 / 108190403 -ID:- Length:2219 Species:Danio rerio


Alignment Length:2163 Identity:560/2163 - (25%)
Similarity:891/2163 - (41%) Gaps:487/2163 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 KGDIV----SVGLQ-GGEVR------------DIKSEKVEK------VNPPKFEKIEDMADMTVL 97
            |||.|    |.|:| |.|||            :.|..|::|      ::|.....::||..:..|
Zfish     6 KGDYVWVDCSDGVQIGAEVRLSDTGQLQLIDDEGKEHKIKKESTLKPMHPTSVNGVDDMIRLGDL 70

  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            |...:|.||..||....||||:|...||:|||:..|:||....:.|..:|..::|||:|||:|..
Zfish    71 NEAGLLRNLLVRYKEGAIYTYTGSILVAVNPYQLLPIYTPEQVEQYTDRRLGDLPPHVFAIADSC 135

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            :.:|..|..:|..:|:|||||||||:||.::.:.|.|...:..         :|.||::.||:||
Zfish   136 FFNMRRNRKDQCCIISGESGAGKTESTKLMLQFLAAVSGQRSW---------IEQQVLEANPILE 191

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            |||||||:||||||||||:|.|||..:|.:.||.||.|||||:||..|.|.||:|||||.::.| 
Zfish   192 AFGNAKTIRNDNSSRFGKYIDIHFNKSGAIEGARIEQYLLEKSRVCRQASQERNYHIFYCMLMG- 255

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGKVT-VASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVM 356
            :|..:...|...|..:|:.::.||.| ....||.:|::....|..||.||:.:..::.::.|:::
Zfish   256 MPADQKKILSLGNAAEYNYLTMGKCTSCEGRDDIKEYASFRSAMKILTFTENDTWEINKLLASIL 320

  Fly   357 HMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAE-----------------LYKNLLKPRIK 404
            |:|.:.|::.               .::.|.|||...                 |..:|.:..:.
Zfish   321 HLGNVDFEET---------------IMNNLEGCDILSSTHFKMATQLLEVAPNALDASLTQRSLM 370

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-----DTQQKRQHFIGVLDIAGF 464
            ...|.||:.....|..:...|..|.::.|||.|:|.|.|..:     |..:..:|.||:|||.||
Zfish   371 TNRESVTKPLTSAQALDGRDAFVKAIYGRLFVWIVTKINSAIYKPPSDDPKHVRHSIGLLDIFGF 435

  Fly   465 EIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFG-----MDLLACIDLIE 524
            |.|:.|.||||||||.||:|||||..|:|.|||:||.||.|.|..|:|.     :|:||.     
Zfish   436 ENFKNNSFEQLCINFANEQLQQFFVKHVFKLEQQEYAREDIVWKNIEFNDNQSTLDVLAI----- 495

  Fly   525 KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYN 589
            |.:.|||:::|||.|||.||.|...|: |.|.||...:..||    ......|.|.|:||.|.|:
Zfish   496 KSLNILSLIDEESRFPKGTDATMLNKM-NQHHGKGDIYMPPK----NNHETQFGIRHFAGVVHYD 555

  Fly   590 ITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF------------ADHAGQSGGGEQAKGGRGKKG 642
            ..|:||||:|.|:..::.....|.||||.:||            .:|...:......:....|| 
Zfish   556 SKGFLEKNRDALSSDIIQLIHTSSNKLLKQIFHSEISTIEGKTSINHTIVTPKSSLRQTADTKK- 619

  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707
             ...|::..:::.|:|||.||.:.||.|:|||.||:.|:|.:.|..|.:.||..:|::|.|||.:
Zfish   620 -QVPTLTGQFRQSLDSLMKTLTACQPFFIRCIKPNDFKKPMLFDRELCIRQLRYSGMMETIRIRK 683

  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLL--QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLG 770
            .|:|.|..:.:|..||:::....:  ...|..||..|.|.|.| |.||.:::|.||||.:.....
Zfish   684 AGYPIRHTFDEFLERYRVLLKSTVCDPQTETVKKCCESICKII-LTEDDWKIGKTKVFLKDFHDT 747

  Fly   771 QMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVAL-------------KVVQ---RNLRK 819
            .:|..||:.|.:....:|...|||..||.|.:.:...|.:             :|||   ..|:.
Zfish   748 VLELARDKALNEKALLIQKVLRGYKHRKAFLRKRGAAVTIQKTWRGHKGRKLYRVVQLGYARLQA 812

  Fly   820 YLQLRTWPW-YKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEK 883
            .::.|...| ||..:|...||. |:....:||.|.|.|:...:         .|:|.....||.|
Zfish   813 QVRSRKMAWEYKQKRKATLLLQ-SQTRGCLARKEWKRKRDAVI---------LLQAYTRGTLARK 867

  Fly   884 TALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ--EEDARNQLFQQKKKADQE- 945
            .  ::.:  ::.|....|||.|:..|.   ||.| |.::|.|.|  |.:|..||   :...||| 
Zfish   868 A--VNKM--KRDAFLSLQERRAEELAA---LERQ-RRLEEVLRQKREREAAQQL---ESITDQEM 921

  Fly   946 -----------ISGLK-------KDIEDLELNVQKAEQDKA------TKDHQIRNLNDEIAHQDE 986
                       :.|.:       :|:|.....:::.:.|.|      .:|:      |::   ||
Zfish   922 VDDIFGFLPSMVGGQEGQAPVGFEDLEGKRTVLEEVDLDDAPMMPIPEEDY------DDL---DE 977

  Fly   987 LINKLNKEKKMQG-----ETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
            ...........||     ...|:..:.|...||:    |.|.|.|......|        :..||
Zfish   978 YSFSKFASMYFQGAATPTHIRQRLRQPLLYHEDE----NDVLASLTVWWMIL--------RFMGD 1030

  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELS---SITAKLEDEQVVVLKHQRQIK 1108
            :.:.|.:|     :::...|..:|:.:  :....|:|:.||   .:..::.:.::|..|....:.
Zfish  1031 LPEPKAQV-----VSRSGTAFADRSVQ--KDVASRQDRRLSHMVGVDQRIRNSRIVQNKAVPTVP 1088

  Fly  1109 E--------------LQARIEELEEEVEAERQARAKAEK----QRADLARELEELGERLEEAGGA 1155
            |              |....:.::::....|:..|..|:    ::.....::.....:...|.|.
Zfish  1089 EEASRNRKSSTFTDLLSRSRKSVQDDGVPNRKLSALPEQGPRNRKTSTFTDIMSRNRKTSTAEGP 1153

  Fly  1156 TSAQIELNKKREAELSKLRRDLEE-ANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKE 1219
            .|     ||:...:.|.:..:.|: :.:..:||:..:.::.     ||  ..|.|...:.....|
Zfish  1154 PS-----NKRSARKPSVIAEEAEDGSEVPRQSTVQTISEED-----EM--NTDGLTLDRPMTSLE 1206

  Fly  1220 KNE----YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNE----------------------- 1257
            |..    |.....|||   |.|..:      |.||||...|.                       
Zfish  1207 KLHIIVGYAIVRRDLR---DEIYCQ------ICKQLQENSNRGSFFRGWILLSICLGIFPPTERF 1262

  Fly  1258 ---VQSKL------------DETNRTLN-----------DFDASKKKLSIENSDLLRQLEEAESQ 1296
               :||.|            :...||:.           :..|:|.|..|..|..|.........
Zfish  1263 IKYLQSFLRFGPVGYAPYCAERLRRTVANGVRGEPPSWLELQATKSKKPIAISVTLMDGRTISMP 1327

  Fly  1297 VSQLSKIK-----ISLTTQLEDT------KRLADEESRERATLLGKFRNLEHDLDNLREQVEEEA 1350
            |...|..|     :|...:|:||      ..|.|     :...||..|  ||.:|.: .|.|:|.
Zfish  1328 VDSASTSKEVCQMLSQKVKLQDTFGFSIYVALYD-----KVWSLGSGR--EHVMDAI-SQCEQEV 1384

  Fly  1351 EGKADLQRQLSKANAEAQVWRSKYE-----------SDGVARSEELEEAKRKLQ--ARLAEAEET 1402
            :.|...::...        ||..:.           .|.|:......:..|.|:  ....|.||.
Zfish  1385 KRKGGQEQHAP--------WRLYFRKEVFAPWHDCAQDNVSTDLIYRQVIRGLKYGEYQCEKEED 1441

  Fly  1403 IESLNQK--------CIGLEKTK---------QRLSTEVEDLQLE-VDRANAIANAAEKKQKAFD 1449
            ...|..|        .|.:|.||         :.|..:.||...: |:.|:|.......:.|: |
Zfish  1442 YVGLAAKHFYVQHGSDISMENTKTVVRECINSKLLEAKSEDKWAQMVNTAHAQGPFITSRTKS-D 1505

  Fly  1450 KIIGEWKLKVDDLAAELDASQKECRNYST--ELFRLKGAYEEGQEQLEAVRRENKNLADE-VKDL 1511
            |:    |.:|.|.     |.||....:|.  |:.:|.|......:.:.|:........|| .|:|
Zfish  1506 KV----KAEVVDF-----ARQKWPMFFSKFFEVAKLSGPPLPKSKFILAINSTGITFLDEREKNL 1561

  Fly  1512 L----DQIGEGGRNIHEIEKARKRLEAEKD-ELQA--ALEEAEAALEQEENKVLRAQ--LELSQV 1567
            |    .:: .|...|.| .|....|..:.| .|.|  |:|.::.........:.|:|  :.|.:|
Zfish  1562 LILSYPEL-TGVNTIRE-RKCVCLLTLKGDFTLNAIMAVEISDLVAMFLAGLIQRSQYAVALQEV 1624

  Fly  1568 RQEIDRRIQE----------KEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADIN 1622
            .::.||.|..          |:|||...|               ...|||.|.......:.||  
Zfish  1625 NRQDDRTILSFKKAELIYLIKDEEFSAAR---------------GWLKGKNERTGEIGAIPAD-- 1672

  Fly  1623 ELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNE--LE 1685
             ..:.|....|...|....|.....|.|   |.::...:..        ::||.|.:...|  :|
Zfish  1673 -AVLILPTLTKPTNEVLSLISLSPDQRK---TIIDNTSKGT--------LTERVAPSTLKEFSVE 1725

  Fly  1686 ESRTLLEQADR---GRRQAEQEL-ADAHEQLN-----------EVSAQNASISAA---------K 1726
            ..|..::..:|   .:....:.| |::.|.:.           ::|.|...:..|         .
Zfish  1726 YFRPPIKDVNRQVISKNATPERLWANSREPIRQPLLKRLVGNPDLSPQACQVFTAILKYMGDYPT 1790

  Fly  1727 RKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQ--QI 1789
            |:::|.|:.    .|::......:||           |.||:..:.....|....|.::||  |:
Zfish  1791 RQVQSPLEL----TDQIFGPPTQNEE-----------LRDEIYCQIMKQMTSNNNRYSIEQGWQL 1840

  Fly  1790 KELQVRLDEAEANALKGGKKAIQ--KLEQRVRELENELDGEQRR----------HADA-QKNLRK 1841
            ..|...|.....:.:|..::.|:  |.|....:....|.|.:|.          ..|| |:|   
Zfish  1841 LWLCCGLFPPSNSLMKHAQRFIETRKREPLATDCLQRLQGARRMDPRKLPPHQVEVDAIQQN--- 1902

  Fly  1842 SERRVKELSFQSEEDR----KNHERMQDLVDKLQQKI-----KTYKRQIEEAEEIAALNLAK-FR 1896
            |.:...::.|.::...    ..:.:::|||..:..|:     :.:...::..:::.:||... |.
Zfish  1903 STQIFHKIYFPNDSQEIFEVATNTKIRDLVRTIANKLMLSTAEGFSLFMKTPDKVLSLNETDYFF 1967

  Fly  1897 KAQQELEEAEERADLAEQ 1914
            .:.:::.:..:||....|
Zfish  1968 DSLRQITDWSKRAKRVNQ 1985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/33 (33%)
MYSc 81..777 CDD:214580 272/737 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 266/706 (38%)
Myosin_tail_1 842..1897 CDD:279860 249/1276 (20%)
V_Alix_like 1557..1877 CDD:187408 71/381 (19%)
ATP-synt_B <1671..1771 CDD:304375 22/125 (18%)
TMPIT 1739..>1825 CDD:285135 17/89 (19%)
LOC108190403XP_021327440.1 MYSc_Myo7 73..742 CDD:276832 266/706 (38%)
IQ 779..801 CDD:197470 1/21 (5%)
MyTH4 <1198..1307 CDD:214535 20/117 (17%)
B41 1314..1527 CDD:214604 52/238 (22%)
FERM_C1_MyoVII 1521..1614 CDD:270019 20/94 (21%)
SH3 1615..1676 CDD:327375 17/78 (22%)
MyTH4 1752..1900 CDD:214535 29/162 (18%)
B41 1907..2119 CDD:214604 11/79 (14%)
FERM_C2_MyoVII 2115..2210 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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