Protein Alignment Mhc and LOC101730386

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_031747221.1
• Gene: LOC101730386 / 101730386
• XenbaseID: XB-GENE-29084515
• Length: 1937
• Species: Xenopus tropicalis
• Alignment Length: 1923
• Identity: 1072/1923 - (55%)
• Similarity: 1431/1923 - (74%)
• Gaps: 12/1923 - (0%)

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQ 79
            |:|....::|...|:||:|:|.||::.|:||.|:.|.:.:..|..|:|.....:|..:::|.:..
 Frog    15 PFLRKPEKERLEAQNKPFDAKNSCFVHDDKELYVKGTVVSRDGGKVTVNTVDDKTVTVREDQVNP 79

  Fly    80 VNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .||||::|.|||:.||:||:||||:||::||...:||||||||||.:||||..|||.......||
 Frog    80 QNPPKFDKIEDMAMLTHLNEASVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAGYR 144

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT---VGASKKTD 206
            ||:|.|.|||||:|||.||..|..:..|||:|||||||||||.|||:||.||||   :|.|||.:
 Frog   145 GKKRQEAPPHIFSISDNAYQFMSQDRENQSILITGESGAGKTVNTKRVIQYFATIAAIGDSKKKE 209

  Fly   207 EAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKAR 271
            ...:.:|:||||::|.||:|||||||||||||||||||||||||||.|||||.||||||||||:|
 Frog   210 STNRLQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSR 274

  Fly   272 VISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFD 336
            |..|.|.||||||||||::...|.:.::.|||.|.|||..:|||::.|.||||.||...||.|.|
 Frog   275 VTFQLSAERSYHIFYQILTNKKPEIVEMLLLTTNPYDYAFISQGEIAVKSIDDEEELMATDSAID 339

  Fly   337 ILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKP 401
            |||||.:||..:|::|.||||.|.|||||:.||||||.||.|...::..|.|.::|:|.|.|..|
 Frog   340 ILGFTTEEKMGIYKMTGAVMHKGNMKFKQKQREEQAEPDGTEVADKIGYLMGLNSADLLKALCYP 404

  Fly   402 RIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEI 466
            |:||||||||:|:.||||.|:||||.|.|:::||.|:|.:.|:.|||:..||:||||||||||||
 Frog   405 RVKVGNEFVTKGQTVQQVYNAIGALSKSVYEKLFLWMVARINQQLDTKLPRQYFIGVLDIAGFEI 469

  Fly   467 FEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILS 531
            |:.|..||||||||||||||||||||||||||||::|||:|.||||||||..||:||||||||.|
 Frog   470 FDLNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFS 534

  Fly   532 ILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEK 596
            |||||.|||||||.:|..||.:.||||...|:||||.| |:..|||::.||||.|.|||.|||:|
 Frog   535 ILEEECMFPKATDTSFKNKLYDQHLGKCKNFEKPKPAK-GKAEAHFSLVHYAGTVDYNICGWLDK 598

  Fly   597 NKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMT 661
            ||||||:|||..::||..|||..:::.::|....|:.||.|:.|||..|.|||:.::|.||.|||
 Frog   599 NKDPLNETVVGLYQKSPVKLLSFLYSSYSGADSAGDGAKSGKKKKGSSFQTVSALFRENLNKLMT 663

  Fly   662 TLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIM 726
            .||||.||||||:||||.|.||:::.||::|||.||||||||||||||||:|::|.|||.||||:
 Frog   664 NLRSTHPHFVRCLIPNESKTPGIMENHLIIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKIL 728

  Fly   727 CPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQ 788
            ....:   |.:: .|||:|.::..||:...|||.|:|||||:||:||.:||.||::|.:|::..|
 Frog   729 NANAIPEGQFID-SKKASEKLLTSIDIDHTQYRFGHTKVFFKAGLLGVLEEMRDDKLAEIITKTQ 792

  Fly   789 AWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL-E 852
            |..||:|.|..|||:.|:|.|:.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.: |
 Frog   793 ALCRGFLMRVEFKKMVERRDAIYVIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKE 857

  Fly   853 EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQ 917
            |.||..|.|..::.: :||||.....||.||..|......|...|.|.:||...|...|.:||.:
 Frog   858 EFAKTKEALTKSDAR-KKELEEKMVALLQEKNDLQLQCQSESENLADAEERCEGLIKNKINLEAK 921

  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982
            ::::.|||..||::..:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|
 Frog   922 IKELTERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 986

  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDV 1047
            ..||.|:::.||||...|.:|:|.::|||.|||::.|:|.|.||||.:|:||.|||:|||:|.|:
 Frog   987 GLDENISRITKEKKALQEAHQQTLDDLQAEEDKVSSLSKAKTKLEQQVDDLEGSLEQEKKLRLDL 1051

  Fly  1048 EKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQA 1112
            |::|||:||||||:||.:.|||.:|::.|:.:::||.|:|.:.:|:||||.:..:.|::||||||
 Frog  1052 ERAKRKLEGDLKLSQETIMDLENDKQQTEEKLKKKDFEMSQLQSKIEDEQTLASQLQKKIKELQA 1116

  Fly  1113 RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDL 1177
            ||||:|||:||||.||||.||||:||:|||||:.|||||||||||||||:|||||||..||||||
 Frog  1117 RIEEVEEEIEAERAARAKVEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKLRRDL 1181

  Fly  1178 EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKA 1242
            ||:.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.:::::..||
 Frog  1182 EESTLQHEATSAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKA 1246

  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307
            ..||:::.|:..|:|::|:.||..|.:||..|.|.:|..|..:..|||||.||.:||||:.|.:.
 Frog  1247 NIEKVSRVLEDQLSEIKSRDDEHQRIINDLTAQKARLQTETGEQSRQLEEKESLISQLSRAKQAF 1311

  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372
            |.|.|:.||..:|||:.:..|....::..||.|.||||.|||.|.||:|||.|||||.|...||:
 Frog  1312 TQQTEELKRQLEEESKAKNALAHALQSSRHDCDLLREQFEEEQEAKAELQRSLSKANTEVSQWRT 1376

  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAI 1437
            |||:|.:.|:|||||||:||..||.||||.:|::|.||..||||||||..|||||.::|:|||:.
 Frog  1377 KYETDAIQRTEELEEAKKKLAQRLQEAEEQVEAVNSKCASLEKTKQRLQAEVEDLMVDVERANSA 1441

  Fly  1438 ANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENK 1502
            |.|.:|||:.|||::.|||.|.::..:||:|:|||.|:.|||:|::|.||||..|.||.::||||
 Frog  1442 AAALDKKQRNFDKVLVEWKQKYEEGQSELEAAQKEARSLSTEIFKMKNAYEEALEHLETMKRENK 1506

  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567
            ||..|:.||.:|:||..:||||:|||:|::|.||.:|||||||||.:||.||.|:||.||||:||
 Frog  1507 NLQQEISDLTEQMGETVKNIHELEKAKKQVEQEKGDLQAALEEAEGSLEHEEAKILRIQLELNQV 1571

  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632
            :.|:||:|.||:||.|..::|.||.:|:||::|::|.:.:.:|||:|||:|.|:|||||.|.|||
 Frog  1572 KSEVDRKIAEKDEEIEQLKRNTQRVIDTMQSTLDSEIRSRNDALRLKKKMEGDLNELEIQLGHAN 1636

  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697
            :...||||.::..|.||||.|..|::..||:||.:|||.:.|||.|..|.|:||.|:.|||.:|.
 Frog  1637 RQAGEAQKQLRNVQAQLKDTQLQLDDATRAQDDMKEQLAVVERRNNLQQAEIEEMRSALEQTERS 1701

  Fly  1698 RRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAA 1762
            |:.|||||.||.|::..:.:||.|:...|:||||::..|.::::|.:.||:|:|||||||:.|||
 Frog  1702 RKVAEQELLDASERVQLLHSQNTSLLNTKKKLESDIVQLQNEVEESVQEARNAEEKAKKAITDAA 1766

  Fly  1763 RLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDG 1827
            .:|:||:.|||.:...|:::|.|||.:|:||.||||||..|:|||||.:||||.||||||||||.
 Frog  1767 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLESRVRELENELDA 1831

  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNL 1892
            ||:|.::..|.:||.|||||||::|:||||||..|:||||||||.|:|.||||.||:||.|...|
 Frog  1832 EQKRGSEGIKGVRKYERRVKELTYQTEEDRKNVLRLQDLVDKLQLKVKAYKRQAEESEEQANAYL 1896

  Fly  1893 AKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGR 1930
            |:|||.|.||||:|||||:||..::|.|||.|  .:|:
 Frog  1897 ARFRKVQHELEESEERADIAESQVNKLRAKSR--DIGK 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	13/41 (32%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	421/670 (63%)
		Myosin_tail_1	842..1922	CDD:460256	578/1080 (54%)
LOC101730386	XP_031747221.1	Myosin_N	33..77	CDD:460670	14/43 (33%)
		MYSc_class_II	100..769	CDD:276951	421/670 (63%)
		Myosin_tail_1	849..1926	CDD:460256	578/1077 (54%)