DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myh7ba

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001311408.1	Gene:	myh7ba / 100884147	ZFINID:	ZDB-GENE-100914-2	Length:	1938	Species:	Danio rerio

Alignment Length:	1945	Identity:	1052/1945 - (54%)
Similarity:	1418/1945 - (72%)	Gaps:	18/1945 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQ 65
            |.:.:..:|..:..|:|..|..:....|:..:|.||..||||:|:.|:..|||...||.|.|..:
Zfish     1 MSRMLDMKEFGEAAPFLRKSDLELLAAQTVAFDGKKRAWIPDDKDAYIEVEIKQIDGDRVEVETK 65

  Fly    66 GGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYK 130
            .|:...:|.:.::::|||||:.|||||.:|.||...||.|||:||.:.:||||||||||.:||||
Zfish    66 DGKCLTVKEDDIQQMNPPKFDLIEDMAMLTHLNEASVLFNLRRRYSSWMIYTYSGLFCVTVNPYK 130

  Fly   131 RYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAY 195
            ..||||......|:||||:|.||||::|:|.||.|||.|..|||||||||||||||.|||:||.|
Zfish   131 WLPVYTAPVVAAYKGKRRSEAPPHIYSIADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQY 195

  Fly   196 FATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260
            ||.|.|  ..:.|||..|:||||:::.||.:||||||||:|||||||||||||||||||||||.|
Zfish   196 FAIVAA--LGEAAAKKGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASA 258

  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325
            ||:.|||||:|||.||..||||||:|||||...|.:.|:.|::.|.||||..|||..||.::||.
Zfish   259 DIDIYLLEKSRVIFQQPGERSYHIYYQIMSQKKPELLDMLLVSSNPYDYHFCSQGVTTVENMDDG 323

  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390
            :|...||.|.||||||.:||...|:|..|:||.|.|||||:.||||||.||.|...:.|.|.|..
Zfish   324 QELMATDHAMDILGFTPEEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKASYLMGVS 388

  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHF 455
            :|:|.|.||.||:|||||:|.:|:||:||..::|||.|..:||:|||||.:.|.||.|...||.|
Zfish   389 SADLIKGLLHPRVKVGNEYVVKGQNVEQVNYAVGALAKATYDRMFKWLVGRINRTLYTALPRQFF 453

  Fly   456 IGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACI 520
            |||||||||||||.|.||||||||||||||||||||||:|||||||||||:|.|||||:||.|||
Zfish   454 IGVLDIAGFEIFELNSFEQLCINFTNEKLQQFFNHHMFILEQEEYKREGIEWTFIDFGLDLQACI 518

  Fly   521 DLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGC 585
            ||||||:||:||||||.|||||||.:|..||.:.||||||.||||:|.|..:..|||.:.||||.
Zfish   519 DLIEKPLGIMSILEEECMFPKATDNSFKAKLFDNHLGKSANFQKPRPDKKRKYEAHFELVHYAGV 583

  Fly   586 VSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG--RGKKGGGFATV 648
            |.|||.|||:|||||||:|||..|:||.||||..::..:.......:...||  :.||...|.||
Zfish   584 VPYNIIGWLDKNKDPLNETVVICFQKSSNKLLASLYEKYVSSDSASDPKTGGKEKRKKAASFQTV 648

  Fly   649 SSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNR 713
            |..:||.||.|||.||||||||||||||||.|.||::|:.:|:|||.||||||||||||||||||
Zfish   649 SQLHKENLNKLMTNLRSTQPHFVRCIIPNETKTPGIMDSFMVLHQLRCNGVLEGIRICRKGFPNR 713

  Fly   714 MMYPDFKMRYKIMCPKLLQGVEKDK-----KATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQME 773
            |:|.:||.||:|:.|   ..:..||     ||.|.::..:|:..:|||.|:|||||:||:|||:|
Zfish   714 MLYAEFKQRYRILNP---HAIPDDKFVDSRKAAEKLLASLDIDHNQYRFGHTKVFFKAGLLGQLE 775

  Fly   774 EFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPL 838
            |.|||||.||::.:||.:||.:.|....|:.:::.||.::|.|:|.:..::.|||.||:.|:|||
Zfish   776 EMRDERLAKILTLLQAASRGKIMRMELNKMTQRKEALMIIQWNIRAFNIVKNWPWMKLFFKIKPL 840

  Fly   839 LNVSRIEDEIARLEEKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQE 902
            |..:..|.|:|.|:|:..|.:| |..:|.| |||||.....|:.||..|...|..|:..|.|.::
Zfish   841 LRSAATEKELAALKEEFLKLKEALEKSEAK-RKELEEKQVSLIQEKNDLSLQLQAEQDNLADAED 904

  Fly   903 RNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDK 967
            |...|...|..||.:::::.|||..||:....:..:|:|.:.|.:.|||||:|||:.:.|.|::|
Zfish   905 RCDLLIKTKIQLEAKVKEMTERLEDEEEMNATVLAKKRKLEDECAELKKDIDDLEITLAKVEKEK 969

  Fly   968 ATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDE 1032
            ...:::::||.:|:|..||.|.||.||||...|::|:|.::||..|||:|.|.|.||||||.:|:
Zfish   970 HATENKVKNLIEEMAALDETILKLTKEKKALQESHQQTLDDLQTEEDKVNTLTKAKAKLEQQVDD 1034

  Fly  1033 LEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQ 1097
            ||.|||:|||:|.|:|:||||:||||||:.|:|.|||.:|::||:.:::||.|::.|::|:||:|
Zfish  1035 LEGSLEQEKKLRMDLERSKRKLEGDLKLSMESVMDLENDKQQLEEKLKKKDFEMNQISSKIEDDQ 1099

  Fly  1098 VVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIEL 1162
            |::::.|::||||||||||||||:||||..|||.||.|:|.::|||||.|||||||||||||||:
Zfish  1100 VLIIQLQKKIKELQARIEELEEEMEAERSTRAKMEKHRSDSSKELEELSERLEEAGGATSAQIEM 1164

  Fly  1163 NKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQL 1227
            ||||||:..|||||||||.:.||:..|.|||||.|:|.|::||:|.|.::|.|.|||::|...:.
Zfish  1165 NKKREADFLKLRRDLEEAILHHEAMTAALRKKHADSVVELSEQIDSLQRVKQKLEKERSEAKMEA 1229

  Fly  1228 NDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEE 1292
            :||.:.::.:...||..||..:..:..:||.::|::|..|.|:|.:..:.:...|:::|.|:|||
Zfish  1230 DDLTSNLEQLAKGKATAEKTCRLYEDQMNESKAKVEELQRQLSDTNTQRARAQAESAELGRKLEE 1294

  Fly  1293 AESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQ 1357
            .|:.||||.:.|.:.:..:|:.|:..:|||:.:..|....::..||.|.||||.:||.|||::||
Zfish  1295 REALVSQLQRSKNTFSQNIEELKKQLEEESKSKNALTHALQSSRHDCDLLREQYDEEQEGKSELQ 1359

  Fly  1358 RQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLST 1422
            |.|||||||...||:|||:|.:.::|||||||:||..||.|:||.:|:.|.||..|||||.||.:
Zfish  1360 RALSKANAEVAQWRTKYETDAIQKTEELEEAKKKLATRLQESEEQVEASNAKCSSLEKTKHRLQS 1424

  Fly  1423 EVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAY 1487
            |:|||.|:::|:||.|.|.:|||:.||||:.||:.|.::..:||::||||.||.|||||:||.:|
Zfish  1425 EIEDLVLDLERSNAAATALDKKQRQFDKILAEWRHKYEECQSELESSQKESRNLSTELFKLKNSY 1489

  Fly  1488 EEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQ 1552
            ||..:.||:::||:|||.:|:.||.|||.:||:.|||:||.:|.|:.||.|:||||||||..||.
Zfish  1490 EEALDHLESIKRESKNLQEEISDLNDQISQGGKTIHELEKIKKGLDLEKTEIQAALEEAEGTLEH 1554

  Fly  1553 EENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKL 1617
            ||:|.||.||||:|::.:.||::.||:||.:|.|:||||||:||||:|:||||.::||:|:|||:
Zfish  1555 EESKTLRIQLELNQIKADTDRKLAEKDEEIDNLRRNHQRALESMQATLDAEAKSRSEAIRVKKKM 1619

  Fly  1618 EADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQN 1682
            |.|:||:|:.|:|||....|:||.::..|.|:||:|..|:|.....::.:||..::|||.|.|..
Zfish  1620 ENDLNEMEVQLNHANWLATESQKMVRNLQTQIKDLQMELDETVHQNEELKEQSAVTERRNNLLTA 1684

  Fly  1683 ELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEA 1747
            |:||.|..|||.||.|:.||.||.:..|::|.:.:||.|:...|:|||::|.||.|::|:.:.|.
Zfish  1685 EVEELRCQLEQNDRARKLAEFELLETTERVNLLHSQNTSMLNQKKKLENDLATLSSEVDDAVQEC 1749

  Fly  1748 KNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQ 1812
            :|:|||||||:.|||.:|:||:.|||.:...|:::|.:||.||:||:||||||..|||||||.||
Zfish  1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQLRLDEAEQIALKGGKKQIQ 1814

  Fly  1813 KLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTY 1877
            |||.:||:||:||:.||::..:.||.:||.|||:|||::|:||||||..|:|:|:||||.|:|||
Zfish  1815 KLESKVRDLESELESEQKKSNELQKGIRKYERRIKELTYQTEEDRKNIARLQELIDKLQAKVKTY 1879

  Fly  1878 KRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPR 1937
            |||.|:|||.|..||.|::|.|.||::||||||:||..::|.|.:.|    ..|:...|:
Zfish  1880 KRQAEDAEEQANSNLTKYKKIQHELDDAEERADIAESQVNKLRTRSR----DSGSKTTPK 1935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	15/36 (42%)
		MYSc	81..777	CDD:214580	444/702 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	423/671 (63%)
		Myosin_tail_1	842..1897	CDD:279860	539/1055 (51%)
		V_Alix_like	1557..1877	CDD:187408	168/319 (53%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
myh7ba	NP_001311408.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1098	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2094	1.000	Inparanoid score	I40
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24867
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.870