Protein Alignment Mhc and LOC100495968

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_002935256.2
• Gene: LOC100495968 / 100495968
• -ID: -
• Length: 1941
• Species: Xenopus tropicalis
• Alignment Length: 1914
• Identity: 1036/1914 - (54%)
• Similarity: 1397/1914 - (72%)
• Gaps: 14/1914 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85
            |:.||: |:||:|:|.:.:|.|....::.|.|.|..||.::|..:.|....:...::.:.||||:
 Frog    21 EKERIEAQNKPFDAKNTVYIDDTNTLFVKGFITARDGDKITVKTEDGRTETVTESQIYQQNPPKY 85

  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :||||||.||.||.|.||.||::||.|.:|||||||||:.:||||..|||.......||||:|.|
 Frog    86 DKIEDMAMMTHLNEPSVLFNLKERYAAWMIYTYSGLFCITVNPYKWLPVYNPEVVAGYRGKKRVE 150

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVG----ASKKTDEAAKS 211
            .|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||||.    |.||.......
 Frog   151 APPHIFSISDNAYQSMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAAIGDAGKKKQADNNL 215

  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            ||:||||::|.||:|||||||||:|||||||||||||||||.||||:.||||||||||:||..|.
 Frog   216 KGTLEDQIIQANPLLEAFGNAKTLRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQL 280

  Fly   277 SLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341
            |.||||||||||::..:|.:.::.|||.|.|||..:|||::.|.||||.:||..|:.|.::|||.
 Frog   281 SAERSYHIFYQILTNKIPELIEMLLLTTNPYDYPTISQGELKVKSIDDEDEFMATESAIEVLGFN 345

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            .:|:..:|::|.||||.|.|||||:.||||||.||.|...::|.|.|.::|:|.|.|..||:|||
 Frog   346 AEERVSIYKMTGAVMHHGNMKFKQKQREEQAEPDGTEVADKISYLMGLNSADLLKALCYPRVKVG 410

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            |||||:.:.|.||.||:|||||.|:::||.|:|.:.|:.|||:|.||.|||||||||||||::|.
 Frog   411 NEFVTKSQTVPQVCNSVGALCKSVYEKLFLWMVTRINQQLDTKQPRQFFIGVLDIAGFEIFDFNS 475

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEE 536
            .||||||||||||||||||||||.||||||:|||:|.||||||||.|||:||||||||.||||||
 Frog   476 LEQLCINFTNEKLQQFFNHHMFVQEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEE 540

  Fly   537 SMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPL 601
            .||||||:.:|..||...||||...|:||||.| |:..|||::.||||.|.|||:|||:||||||
 Frog   541 CMFPKATETSFKNKLYEQHLGKCKNFEKPKPGK-GKAEAHFSLVHYAGIVDYNISGWLDKNKDPL 604

  Fly   602 NDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--GGRGKKGGGFATVSSAYKEQLNSLMTTLR 664
            ||:||..::||..|||..:::.:|....|.:.:.  ||:.|||..|.|||:.::|.||.|||.||
 Frog   605 NDSVVQLYQKSSVKLLSFLYSSYASADSGSDSSSKGGGKKKKGSSFQTVSAVFRENLNKLMTNLR 669

  Fly   665 STQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPK 729
            ||.||||||:||||.|.||::|.:|::|||.|||||||||||.||||:|:.|.|||.||||:...
 Frog   670 STHPHFVRCLIPNETKTPGIMDNYLIIHQLRCNGVLEGIRICTKGFPSRIQYGDFKQRYKILNAS 734

  Fly   730 LL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWA 791
            .:   |.:: .|||.|.::..||:..:|||.|:|||||:||:||.:||.|||.|..:::.:|::.
 Frog   735 AIPDGQFID-SKKAAEKLLGSIDVDHNQYRFGHTKVFFKAGLLGTLEEMRDEMLAHVITRIQSYC 798

  Fly   792 RGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAK 856
            ||||.|..|||:..:|.||.|:|.|||.::.::.|||.||:.|:||||..:..|.|:|.::|:.:
 Frog   799 RGYLMRIEFKKMNSRREALFVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMANIKEEYE 863

  Fly   857 KAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRD 920
            |.:| |..||.: :||||.....||.||..|:.....|...|.|.:||...|...|..||:::::
 Frog   864 KIKEALEKAEAR-KKELEEKMVVLLQEKNDLMLQAQAESETLADAEERCESLIKGKIQLESKIKE 927

  Fly   921 IQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQD 985
            :.|||..||::..:|..:|:|.:.|.|.|||||::||:.:.|.|::|...:::::||.:::|..|
 Frog   928 MTERLEDEEESNAELSAKKRKLEDECSELKKDIDELEITLSKVEKEKHATENKVKNLTEDMAALD 992

  Fly   986 ELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKS 1050
            :.|:|:.||||...|.:|:|.::||..|||:|.|:|.|:||||.:|:||.|||:|||:|.|:|::
 Frog   993 DNISKVTKEKKSLQEAHQQTLDDLQTEEDKVNTLSKAKSKLEQQVDDLEGSLEQEKKLRLDLERT 1057

  Fly  1051 KRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIE 1115
            |||:|.|||||||.|.|.|.:|::.|:.:::||.|:|.:.:|:||||.:..:.|::|||||||.|
 Frog  1058 KRKLECDLKLTQETVLDFENDKQQAEERLKKKDYEISQLLSKIEDEQALSSQLQKKIKELQARTE 1122

  Fly  1116 ELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEA 1180
            |||||:||||..|||||||||.:.|||||:.||||||||||:.|||:|||||.|..|:|||||||
 Frog  1123 ELEEEIEAERTVRAKAEKQRALITRELEEISERLEEAGGATAVQIEMNKKRENEFQKMRRDLEEA 1187

  Fly  1181 NIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQE 1245
            |::||:...||||||.|.|||:.||:|.|.::|.|.||||:|...:::|..:.:|:.:..||..|
 Frog  1188 NLRHETIACNLRKKHADTVAELGEQLDNLQRIKQKLEKEKSELKMEIDDFASNLDNTSKLKANFE 1252

  Fly  1246 KIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQ 1310
            |:...|:..|:|.::|.:|..|.|||....|.:|..||.:|.||.||.||.:||||:.|.:...|
 Frog  1253 KLNHVLEDQLSEAKAKGEEQQRLLNDLTTHKARLLSENGELSRQGEEKESLISQLSRGKQAFIQQ 1317

  Fly  1311 LEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYE 1375
            :|:.||..:||::.:..|....::..||.|.||||.|||.|.|::|||.|||||.|...||:|||
 Frog  1318 IEELKRQLEEETKAKNALAHAVQSARHDCDLLREQFEEEQEAKSELQRSLSKANNEVSQWRNKYE 1382

  Fly  1376 SDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANA 1440
            :|.:.|:|||||||:||...|.|||:.:.::|.||..||||||||.:||:||.::|:|:|..|.|
 Frog  1383 TDAIQRTEELEEAKKKLAQHLQEAEDQVAAVNSKCASLEKTKQRLQSEVDDLMIDVERSNNAAAA 1447

  Fly  1441 AEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLA 1505
            .:|||:.|||::.|||.|..:..|||:|:.||||:.|||:|:::.||||..|..|.::||||||.
 Frog  1448 LDKKQRNFDKVLVEWKQKYGEGQAELEAALKECRSLSTEIFKMRNAYEEALELTETLKRENKNLQ 1512

  Fly  1506 DEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQE 1570
            .|:.||.:.|||.|::|:|::||||::|.:|:|:||||||||.:||.||.|.||.||||:||:.|
 Frog  1513 QEITDLTEHIGESGKSINELDKARKQVEQQKNEMQAALEEAEGSLEHEETKFLRIQLELNQVKSE 1577

  Fly  1571 IDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKAN 1635
            :|::|.||:||.|..::|:|||.|::|.:|::|.:.:.||||:|||:|.|:|||||.|:.||:..
 Frog  1578 MDKKIAEKDEEIEQLKRNNQRATDTLQTTLDSEIRSRNEALRLKKKMEGDLNELEIQLNQANRQA 1642

  Fly  1636 AEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQ 1700
            |||||.::..|.|.||....|:.::|...|.:||:.:.|||......|:||.|..||..||..:.
 Frog  1643 AEAQKQLRNVQTQNKDTLLQLDNKERIESDLKEQIAVLERRTALQLAEIEEIRAALEMLDRSCKV 1707

  Fly  1701 AEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLA 1765
            |||||||:.|:|..:.:.|.|::.:|:||||::..|.|:::|.:.||:|:|||||||:.|||.:|
 Frog  1708 AEQELADSSERLQLLRSHNTSLTNSKKKLESDVSQLQSEVEESIQEARNTEEKAKKAITDAALMA 1772

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            :||:.|||.:....:::|.|||.:|:||.||||||..|||||||.:||||.|||||||||:.||:
 Frog  1773 EELKKEQDTSAHLVRMKKNLEQTVKDLQHRLDEAEQLALKGGKKQLQKLETRVRELENELENEQK 1837

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            |..:|.|.:||.|||:|||::|:||||||..|:||||||||.|:|.||||.|||||.|..::|::
 Frog  1838 RGVEAVKGVRKYERRMKELTYQNEEDRKNVLRLQDLVDKLQLKVKAYKRQAEEAEEQANAHMARY 1902

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.|.||.|||||||:|:..::|.|||.|
 Frog  1903 RKMQHELGEAEERADIADSQVNKLRAKSR 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	436/704 (62%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	415/673 (62%)
		Myosin_tail_1	842..1897	CDD:279860	534/1055 (51%)
		V_Alix_like	1557..1877	CDD:187408	168/319 (53%)
		ATP-synt_B	<1671..1771	CDD:304375	46/99 (46%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
LOC100495968	XP_002935256.2	Myosin_N	38..72	CDD:280832	9/33 (27%)
		Myosin_head	88..772	CDD:278492	424/685 (62%)
		MYSc_class_II	100..772	CDD:276951	415/673 (62%)
		Myosin_tail_1	852..1929	CDD:279860	549/1077 (51%)
		Uso1_p115_C	902..1007	CDD:282695	38/104 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I21
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2089	1.000	Inparanoid score	I44
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm48957
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070