Protein Alignment Mhc and LOC100495968

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_002935256.2
• Gene: LOC100495968 / 100495968
• XenbaseID: XB-GENE-29082907
• Length: 1941
• Species: Xenopus tropicalis
• Alignment Length: 1914
• Identity: 1034/1914 - (54%)
• Similarity: 1397/1914 - (72%)
• Gaps: 14/1914 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQVNPPKY 85
            |:.||: |:||:|:|.:.:|.|....::.|.|.|..||.::|..:.|.|..:.:..:.|.|||||
 Frog    21 EKERIEAQNKPFDAKNTVYIDDTNTLFVKGFITARDGDKITVKTEDGRTETVTESQIYQQNPPKY 85

  Fly    86 EKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :|.|||:.:|:||:.|||.||::||...:|||||||||:.:||||..|||.......||||:|.|
 Frog    86 DKIEDMAMMTHLNEPSVLFNLKERYAAWMIYTYSGLFCITVNPYKWLPVYNPEVVAGYRGKKRVE 150

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVG----ASKKTDEAAKS 211
            .|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||||.    |.||.......
 Frog   151 APPHIFSISDNAYQSMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAAIGDAGKKKQADNNL 215

  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            ||:||||::|.||:|||||||||:|||||||||||||||||.||||:.||||||||||:||..|.
 Frog   216 KGTLEDQIIQANPLLEAFGNAKTLRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQL 280

  Fly   277 SLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341
            |.||||||||||::..:|.:.::.|||.|.|||..:|||::.|.||||.:||..|:.|.::|||.
 Frog   281 SAERSYHIFYQILTNKIPELIEMLLLTTNPYDYPTISQGELKVKSIDDEDEFMATESAIEVLGFN 345

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            .:|:..:|::|.||||.|.|||||:.||||||.||.|...::|.|.|.::|:|.|.|..||:|||
 Frog   346 AEERVSIYKMTGAVMHHGNMKFKQKQREEQAEPDGTEVADKISYLMGLNSADLLKALCYPRVKVG 410

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            |||||:.:.|.||.||:|||||.|:::||.|:|.:.|:.|||:|.||.|||||||||||||::|.
 Frog   411 NEFVTKSQTVPQVCNSVGALCKSVYEKLFLWMVTRINQQLDTKQPRQFFIGVLDIAGFEIFDFNS 475

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEE 536
            .||||||||||||||||||||||.|||||::|||||.||||||||..||:||||||||.||||||
 Frog   476 LEQLCINFTNEKLQQFFNHHMFVQEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEE 540

  Fly   537 SMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPL 601
            .||||||:.:|..||...||||...|:||||.| |:..|||::.||||.|.|||:|||:||||||
 Frog   541 CMFPKATETSFKNKLYEQHLGKCKNFEKPKPGK-GKAEAHFSLVHYAGIVDYNISGWLDKNKDPL 604

  Fly   602 NDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--GGRGKKGGGFATVSSAYKEQLNSLMTTLR 664
            ||:||..::||..|||..:::.:|....|.:.:.  ||:.|||..|.|||:.::|.||.|||.||
 Frog   605 NDSVVQLYQKSSVKLLSFLYSSYASADSGSDSSSKGGGKKKKGSSFQTVSAVFRENLNKLMTNLR 669

  Fly   665 STQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPK 729
            ||.||||||:||||.|.||::|.:|::|||.|||||||||||.||||:|:.|.|||.||||:...
 Frog   670 STHPHFVRCLIPNETKTPGIMDNYLIIHQLRCNGVLEGIRICTKGFPSRIQYGDFKQRYKILNAS 734

  Fly   730 LL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWA 791
            .:   |.:: .|||.|.::..||:..:|||.|:|||||:||:||.:||.|||.|..:::.:|::.
 Frog   735 AIPDGQFID-SKKAAEKLLGSIDVDHNQYRFGHTKVFFKAGLLGTLEEMRDEMLAHVITRIQSYC 798

  Fly   792 RGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAK 856
            ||||.|..|||:..:|.||.|:|.|||.::.::.|||.||:.|:||||..:..|.|:|.::|:.:
 Frog   799 RGYLMRIEFKKMNSRREALFVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMANIKEEYE 863

  Fly   857 KAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRD 920
            |.:| |..||.: :||||.....||.||..|:.....|...|.|.:||...|...|..||:::::
 Frog   864 KIKEALEKAEAR-KKELEEKMVVLLQEKNDLMLQAQAESETLADAEERCESLIKGKIQLESKIKE 927

  Fly   921 IQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQD 985
            :.|||..||::..:|..:|:|.:.|.|.|||||::||:.:.|.|::|...:::::||.:::|..|
 Frog   928 MTERLEDEEESNAELSAKKRKLEDECSELKKDIDELEITLSKVEKEKHATENKVKNLTEDMAALD 992

  Fly   986 ELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKS 1050
            :.|:|:.||||...|.:|:|.::||..|||:|.|:|.|:||||.:|:||.|||:|||:|.|:|::
 Frog   993 DNISKVTKEKKSLQEAHQQTLDDLQTEEDKVNTLSKAKSKLEQQVDDLEGSLEQEKKLRLDLERT 1057

  Fly  1051 KRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIE 1115
            |||:|.|||||||.|.|.|.:|::.|:.:::||.|:|.:.:|:||||.:..:.|::|||||||.|
 Frog  1058 KRKLECDLKLTQETVLDFENDKQQAEERLKKKDYEISQLLSKIEDEQALSSQLQKKIKELQARTE 1122

  Fly  1116 ELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEA 1180
            |||||:||||..|||||||||.:.|||||:.||||||||||:.|||:|||||.|..|:|||||||
 Frog  1123 ELEEEIEAERTVRAKAEKQRALITRELEEISERLEEAGGATAVQIEMNKKRENEFQKMRRDLEEA 1187

  Fly  1181 NIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQE 1245
            |::||:...||||||.|.|||:.||:|.|.::|.|.||||:|...:::|..:.:|:.:..||..|
 Frog  1188 NLRHETIACNLRKKHADTVAELGEQLDNLQRIKQKLEKEKSELKMEIDDFASNLDNTSKLKANFE 1252

  Fly  1246 KIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQ 1310
            |:...|:..|:|.::|.:|..|.|||....|.:|..||.:|.||.||.||.:||||:.|.:...|
 Frog  1253 KLNHVLEDQLSEAKAKGEEQQRLLNDLTTHKARLLSENGELSRQGEEKESLISQLSRGKQAFIQQ 1317

  Fly  1311 LEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYE 1375
            :|:.||..:||::.:..|....::..||.|.||||.|||.|.|::|||.|||||.|...||:|||
 Frog  1318 IEELKRQLEEETKAKNALAHAVQSARHDCDLLREQFEEEQEAKSELQRSLSKANNEVSQWRNKYE 1382

  Fly  1376 SDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANA 1440
            :|.:.|:|||||||:||...|.|||:.:.::|.||..||||||||.:||:||.::|:|:|..|.|
 Frog  1383 TDAIQRTEELEEAKKKLAQHLQEAEDQVAAVNSKCASLEKTKQRLQSEVDDLMIDVERSNNAAAA 1447

  Fly  1441 AEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLA 1505
            .:|||:.|||::.|||.|..:..|||:|:.||||:.|||:|:::.||||..|..|.::||||||.
 Frog  1448 LDKKQRNFDKVLVEWKQKYGEGQAELEAALKECRSLSTEIFKMRNAYEEALELTETLKRENKNLQ 1512

  Fly  1506 DEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQE 1570
            .|:.||.:.|||.|::|:|::||||::|.:|:|:||||||||.:||.||.|.||.||||:||:.|
 Frog  1513 QEITDLTEHIGESGKSINELDKARKQVEQQKNEMQAALEEAEGSLEHEETKFLRIQLELNQVKSE 1577

  Fly  1571 IDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKAN 1635
            :|::|.||:||.|..::|:|||.|::|.:|::|.:.:.||||:|||:|.|:|||||.|:.||:..
 Frog  1578 MDKKIAEKDEEIEQLKRNNQRATDTLQTTLDSEIRSRNEALRLKKKMEGDLNELEIQLNQANRQA 1642

  Fly  1636 AEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQ 1700
            |||||.::..|.|.||....|:.::|...|.:||:.:.|||......|:||.|..||..||..:.
 Frog  1643 AEAQKQLRNVQTQNKDTLLQLDNKERIESDLKEQIAVLERRTALQLAEIEEIRAALEMLDRSCKV 1707

  Fly  1701 AEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLA 1765
            |||||||:.|:|..:.:.|.|::.:|:||||::..|.|:::|.:.||:|:|||||||:.|||.:|
 Frog  1708 AEQELADSSERLQLLRSHNTSLTNSKKKLESDVSQLQSEVEESIQEARNTEEKAKKAITDAALMA 1772

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            :||:.|||.:....:::|.|||.:|:||.||||||..|||||||.:||||.|||||||||:.||:
 Frog  1773 EELKKEQDTSAHLVRMKKNLEQTVKDLQHRLDEAEQLALKGGKKQLQKLETRVRELENELENEQK 1837

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            |..:|.|.:||.|||:|||::|:||||||..|:||||||||.|:|.||||.|||||.|..::|::
 Frog  1838 RGVEAVKGVRKYERRMKELTYQNEEDRKNVLRLQDLVDKLQLKVKAYKRQAEEAEEQANAHMARY 1902

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.|.||.|||||||:|:..::|.|||.|
 Frog  1903 RKMQHELGEAEERADIADSQVNKLRAKSR 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	12/41 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	413/673 (61%)
		Myosin_tail_1	842..1922	CDD:460256	549/1080 (51%)
LOC100495968	XP_002935256.2	Myosin_N	33..77	CDD:460670	12/43 (28%)
		MYSc_class_II	100..772	CDD:276951	413/673 (61%)
		Myosin_tail_1	852..1929	CDD:460256	549/1077 (51%)