DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myo10.2

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_031749628.1 Gene:myo10.2 / 100495096 XenbaseID:XB-GENE-5995373 Length:1997 Species:Xenopus tropicalis


Alignment Length:2052 Identity:480/2052 - (23%)
Similarity:847/2052 - (41%) Gaps:493/2052 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRN 149
            |.:|||:.::.|:...::.|||.||....|||..|....::||||... :|..:|..:|......
 Frog     7 EGVEDMSLLSDLHEASIMLNLRLRYQQDKIYTNIGSILASVNPYKSIAGLYDEKCVDLYSSHHFG 71

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS 214
            |:|||||||::..|..:...|.:|.:||:|||||||||:||.::.:.:::  |:.:.....::..
 Frog    72 ELPPHIFAIANECYRCLWKRHDSQCVLISGESGAGKTESTKLLLKFLSSM--SQNSAGGGGTQTH 134

  Fly   215 LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLE 279
            :|:.:::::|:||||||||||.|:|||||||||::||...|.:.|..:..|||||.||..|...|
 Frog   135 VEEAIMESSPILEAFGNAKTVYNNNSSRFGKFIQLHFSEQGHIQGGRVVDYLLEKTRVTRQSPGE 199

  Fly   280 RSYHIFYQIMSGSVPGVKDICLLTD-NIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQ 343
            |:|||||.:::|:....|:...|:| :.|.| :.:.|..|...::|.:.:.....|..::.|:.:
 Frog   200 RNYHIFYALLTGANREEKEALGLSDPHTYQY-LRASGCATAEGLNDKDMYEKVLAALQVMDFSDE 263

  Fly   344 EKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRV---------SKLFGCDTAELYKNLL 399
            |..:|:::.:.::.:|.::|...|            |.::         :.|.|.|:.:|.:.|.
 Frog   264 EIREVWKLLSGILQLGNLEFMTAG------------GAQITTKAVLSDAADLLGLDSFQLSEVLT 316

  Fly   400 KPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHF--IGVLDIA 462
            :..:.:..|.::....|:|.|:|..:|...::.:.|.||:.:.|..:   :.:::|  :|:|||.
 Frog   317 QRSMILRGEEISSPLTVEQATDSRDSLAMALYAQCFSWLLGRINARI---RGKENFKSVGILDIF 378

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM 527
            |||.|:.|.|||..||:.|||||::||.|:|.|||.||.||||.|..|.: ||...|:|||||.:
 Frog   379 GFENFQVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYNREGIHWDAIGW-MDNAECLDLIEKKL 442

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            |||:::.|||.|||.||.|..|||.|.|      ...|...||......|.|.||||.|:|::.|
 Frog   443 GILALINEESRFPKGTDFTLLEKLHNQH------SNNPHYVKPRVTEHQFGIKHYAGEVTYDVQG 501

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLN 657
            :||||:|...|.:::..:.|:...:.::|.....::.......|.:.||    .||||.::|.|:
 Frog   502 FLEKNRDTFRDDILNMLRDSRLDFVYDLFEKVCSRNSEETLKMGTQRKK----PTVSSQFRESLH 562

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            |||..|.::.|.|:|||.||..|.....:..:|::||..:|:||.::|.|.|||.|.:|.||..|
 Frog   563 SLMAMLSTSNPFFIRCIKPNTEKLSNTFNPDVVLNQLRYSGMLETVKIRRAGFPVRRLYQDFASR 627

  Fly   723 YKIMCPKLLQGVEKDKKATEII-------IKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            ||::.        |:.|||:.:       ::|.:..:.:::||.||||.:..:..::|:.|:..|
 Frog   628 YKMLI--------KNLKATDDVRGKCAAFLQFYEGSKKEWQLGRTKVFLKEALEQKLEKSREGEL 684

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLR------KYLQLR--TWPWYKLWQKVKP 837
            .:..|.:.|..:||::||.|.::   |:::..:|:|.|      .||:||  ...:.|.|:    
 Frog   685 RRAASVICAHIQGYIARKQFTRV---RLSIVTIQKNYRAHFWRATYLRLRQSAVQFQKHWR---- 742

  Fly   838 LLNVSRIEDEIAR------LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGA 896
                    ..:||      |||:.|:.||    |.:.|||.|                       
 Frog   743 --------GTVARRLYQQMLEEERKRREE----EERKRKEEE----------------------- 772

  Fly   897 LQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQ 961
                 ||      ::.:||.|.|..:||..:||:.:.:  |::.:|              ||...
 Frog   773 -----ER------RRRELEEQRRIEEERKRREEEEKRE--QERLEA--------------ELRAA 810

  Fly   962 KAEQDKATKDHQI------RNLNDEIAHQDELINKLNKEKKMQGETNQ--KTGEEL-QAAEDKIN 1017
            :.||:||.....|      |...:||...::.|.||:.::|:.|.:..  :|.:|| :..|::|:
 Frog   811 QEEQEKAKNLENILLQEEERRQMEEILRLEKEIEKLHHQQKLDGVSTSCTETRKELIRQREEQIH 875

  Fly  1018 HLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRK 1082
            .|.|..:::.|...||.|.        |::|:|...:|.....|..|.                 
 Frog   876 KLEKEASRVAQEFLELLDF--------GNLEESAHSLENGFDGTVSAE----------------- 915

  Fly  1083 DKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGE 1147
                .|:.|.|.:                   ||::|...|:.:.........      ||:.|.
 Frog   916 ----GSMVAPLAE-------------------EEVDEGFHADDEMLPPPPPML------LEDDGP 951

  Fly  1148 RLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKL 1212
            |..|                             :...|.|..|:......|.:....:    ..|
 Frog   952 RTSE-----------------------------SFSEEETYTNIPMDVPGAQSSSCTE----TPL 983

  Fly  1213 KAKAEKEKNEYYGQLNDLRAGV-----DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDF 1272
            .........:.|..::|....:     |.::..:..||.|.....    :|:|..|.     .:|
 Frog   984 SPSEPPSAQDPYSAISDKSESIYQCVSDTLSTSEEPQEPIYSYPP----DVESDYDH-----EEF 1039

  Fly  1273 DASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEH 1337
            |.:....|:..||                             ..|.|||.. |.:..|.|.:...
 Frog  1040 DEAPPGSSMNLSD-----------------------------GHLTDEEIM-RISQPGSFGSRCG 1074

  Fly  1338 DLDNLREQVEEEAEGKADLQRQL---------------------SKANAEAQVWRSKYESDGVAR 1381
            .:|:..:. :||.:...|...:|                     .||.....:||.::   .|.:
 Frog  1075 SVDSFLDS-DEEVDSHIDTDEELMTGRVTLFNGGGPPYFHSYLYMKAGGLMNIWRRRW---CVLK 1135

  Fly  1382 SEELEEAKRKLQA-------RLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQ------LEVDR 1433
            .:.....:.|.:|       :......|:...|.|.......:.:|.....|.:      :::..
 Frog  1136 DDTFMWFRTKQEALKSGWLYKKGGGMSTLSRRNWKRRWFVLRESKLMYFENDSEERLRGTIDIRT 1200

  Fly  1434 ANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVR 1498
            |.|:.:..| |:.|.|.:..|   :...:.||   :.::...:...|.|:..|   ..:||..:|
 Frog  1201 AKAVIDIHE-KENALDIVTEE---RTYHIVAE---TPEDASGWFNVLSRVHSA---TSQQLRDMR 1255

  Fly  1499 RENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEE--------- 1554
            .|..|..:.|                            ..|...|.::..|.:..:         
 Frog  1256 DEQANPKNAV----------------------------GTLDVGLIDSVCASDCPDRPNSFVIIT 1292

  Fly  1555 -NKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLE 1618
             |:|:....:::   :|:...|...::.....:.:.|..|.......|.::..|..:|::|::..
 Frog  1293 ANRVIHCNTDIA---EEMHHWISLLQKPRGEAKVDGQEFLVRGWLHKEVQSSNKTASLKLKRRWF 1354

  Fly  1619 ADINELEIALDHANKANAEAQKNIKRYQQQ-----LKDIQTALEEEQRARDDA------------ 1666
            .           .|:.:.:..|:.:|...:     |..:.:.::.:::...:.            
 Frog  1355 V-----------LNRNSLDYYKSSERGGSKLGTLVLNSLCSVVQPDEKVHSETGYWNLVVYGRKH 1408

  Fly  1667 -----REQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAK 1726
                 .:.|..:.|.|||:|..::....:.....:..|..::...:: |.:.:...:|..:...:
 Frog  1409 SYRLYTKLLNEAMRWANAIQGVIDSKAPIETPTQQLIRDIKENSLNS-EAVEQTYKRNPILRYTQ 1472

  Fly  1727 RKLESELQTL-HSDLDELLNEAKNSEEKAKKAMVD-AARLADELRAEQDHAQTQEKLRKALEQQI 1789
            ..|.|.|..| :.|::  ||..|   ||....:.| |.|:.:.|: |.:.......:.:.:.|..
 Frog  1473 HPLHSPLLPLPYGDVN--LNLQK---EKGYTTLQDEAVRIFNSLQ-EIETVPDPVPIIQGILQTC 1531

  Fly  1790 KELQVRLDEAEANALK----------------------------GGKKAIQKLEQRVRELENELD 1826
            ::|:...||.....:|                            .|:..::.|:..::.:.:...
 Frog  1532 QDLKSLRDEVYCQLIKQTNHVPEPNSPGNLRHWQLLSCMSCTFLPGRDILRYLKFHLKRVRDSFP 1596

  Fly  1827 G---EQRRH--ADAQKNLR-----KSERRVKELSFQS--------------EEDRKNHERMQDLV 1867
            |   ||..|  .||.|..:     .|:..:..|..:|              :....:|....::|
 Frog  1597 GTEVEQFAHFIVDALKKTKCREMVPSQEEISALLTRSHMTTSVYCHGGGSCQISINSHTTAGEVV 1661

  Fly  1868 DKLQQKIK-----------TYKRQIEEAEE---IAALNLAKFRKAQQELEEAEERAD-------- 1910
            :||.:.:.           .:.:..:.|.|   |.|..||||.:.....:|.::...        
 Frog  1662 EKLIRGLSMDNSRNMFALFEHNKHTDRAVESRVIVADVLAKFERMAGTADEEDDPGPWNLYFKLY 1726

  Fly  1911 --LAEQAISK------FRAKGRAGSVGRGASPAPRAT 1939
              |..|::.|      |..:....|:..|..|||..|
 Frog  1727 CFLDVQSVPKEGIEFAFMFEQAHESLTSGHFPAPEET 1763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832
MYSc 81..777 CDD:214580 250/710 (35%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 244/684 (36%)
Myosin_tail_1 842..1897 CDD:279860 200/1208 (17%)
V_Alix_like 1557..1877 CDD:187408 58/406 (14%)
ATP-synt_B <1671..1771 CDD:304375 22/101 (22%)
TMPIT 1739..>1825 CDD:285135 18/114 (16%)
myo10.2XP_031749628.1 MYSc_Myo10 21..669 CDD:276840 244/684 (36%)
IQ 729..751 CDD:197470 6/33 (18%)
MYO10_CC 836..880 CDD:407004 12/43 (28%)
MSCRAMM_ClfB <949..1095 CDD:411414 33/218 (15%)
PH-like 1115..>1147 CDD:418428 6/34 (18%)
PH2_MyoX 1150..1251 CDD:270108 17/110 (15%)
PH-like <1278..1322 CDD:418428 5/46 (11%)
PH3_MyoX-like 1316..1441 CDD:270109 16/135 (12%)
MyTH4 1524..1628 CDD:395633 15/103 (15%)
FERM_F1_Myosin-X 1632..1729 CDD:340726 14/96 (15%)
B41 1638..1893 CDD:214604 23/126 (18%)
FERM_C_MyoX 1889..1977 CDD:270023
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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