DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and LOC100493121

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_012809641.1 Gene:LOC100493121 / 100493121 -ID:- Length:1935 Species:Xenopus tropicalis


Alignment Length:1919 Identity:1077/1919 - (56%)
Similarity:1431/1919 - (74%) Gaps:13/1919 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85
            |:.||: |::|:|:|.|.::.|.|:.|:.|.:::.:|...:|..:......:|.:::..:||||:
 Frog    20 EKERIEAQNRPFDAKTSVFVIDPKQMYVKGIVQSKEGGKATVKKEDMSTVTVKDDEIFPMNPPKY 84

  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :||||||.||.||.|.||:||::||.|.:|||||||||..:||||..|||.......||||:|.|
 Frog    85 DKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYNPEVVNAYRGKKRQE 149

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA--SKKTDEAA--KS 211
            .|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:.|  .||.:|||  |.
 Frog   150 APPHIFSISDNAYQYMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAAIGDKKKEEAAPGKI 214

  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            :|:||||::|.||:|||||||||||||||||||||||||||.||||:.||||||||||:||..|.
 Frog   215 QGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQL 279

  Fly   277 SLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341
            |.||||||||||||...|.:.|:.|:|.|.||:..||||::|||||||.||...||.|.|||||.
 Frog   280 SAERSYHIFYQIMSNKRPELIDMLLITTNPYDFPYVSQGEITVASIDDQEELMATDSAIDILGFN 344

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            ..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::|:|.|.|..||:|||
 Frog   345 NDEKNGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLMGLNSADLLKALCYPRVKVG 409

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            |||||:|:.||||.||:|||.|.|::::|.|:|.:.|:.|||:|.||||||||||||||||::|.
 Frog   410 NEFVTKGQTVQQVYNSVGALGKSVYEKMFLWMVIRINQQLDTKQPRQHFIGVLDIAGFEIFDFNS 474

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEE 536
            .|||||||||||||||||||||||||||||:|||||.||||||||.|||:||||||||.||||||
 Frog   475 LEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEE 539

  Fly   537 SMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPL 601
            .|||||||.:|..||.:.|||||..||||||.| |:..|||::.||||.|.|||:|||:||||||
 Frog   540 CMFPKATDTSFKNKLYDQHLGKSNNFQKPKPGK-GKAEAHFSLVHYAGTVDYNISGWLDKNKDPL 603

  Fly   602 NDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRST 666
            |:||:..::||..|||..:::.::|........|||: |||..|.|||:.::|.||.||..||||
 Frog   604 NETVIGLYQKSSVKLLSFLYSAYSGTDADTGGKKGGK-KKGSSFQTVSALFRENLNKLMANLRST 667

  Fly   667 QPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL 731
            .||||||:||||.|.||.:|.:||||||.||||||||||||||||:|::|.|||.||||:....:
 Frog   668 HPHFVRCLIPNETKTPGAMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKILNASAI 732

  Fly   732 ---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARG 793
               |.:: .|||:|.::..||:...||:.|:|||||:||:||.:||.|||||.::::..||..||
 Frog   733 PEGQFID-SKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAQLITRTQAMCRG 796

  Fly   794 YLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKA 858
            ||.|..|:::.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:..::|:.:|.
 Frog   797 YLMRVEFRQMMERRESIFCIQYNVRSFMNVKHWPWMKLYFKIKPLLKSAESEKEMQNMKEEFEKT 861

  Fly   859 EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQE 923
            :|..|.....|||||.....:|.||..|...::.|..:|.|.:||...|...|..||.::::..|
 Frog   862 KEALAKSEAKRKELEEKMVAILQEKNDLHLQVTSESESLADAEERCEGLIKAKIQLEAKIKEFNE 926

  Fly   924 RLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELI 988
            ||..||::..:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|..||.|
 Frog   927 RLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAILDETI 991

  Fly   989 NKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRK 1053
            .||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::|||
 Frog   992 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDMERAKRK 1056

  Fly  1054 VEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELE 1118
            :||||||.||:..|||.::::|::.:::|:.|:|.:.:|:||||.:..:.|::||||||||||||
 Frog  1057 LEGDLKLAQESTMDLENDRQQLDEKVKKKEFEISQLQSKIEDEQALAAQLQKKIKELQARIEELE 1121

  Fly  1119 EEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQ 1183
            ||:||||.|||||||||:||:|||||:.|||||||||||||||:|||||||..|:|||||||.:|
 Frog  1122 EEIEAERAARAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1186

  Fly  1184 HESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIA 1248
            ||:|.:.||||..|:|||:.||:|.|.::|.|.||||:|...:::||.:.::.::..|:..||:.
 Frog  1187 HEATASALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMESVSKAKSNLEKMC 1251

  Fly  1249 KQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLED 1313
            :.|:...:||::|.:|..|.:||.:|.:.:|..||.:..|||||.||.:||||:.|.:.|.|.|:
 Frog  1252 RTLEDQFSEVKTKEEEHLRVINDINAQRARLHTENGEFSRQLEEKESMISQLSRAKQAFTQQTEE 1316

  Fly  1314 TKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDG 1378
            .||..:||::.:..|....::..||.|.||||.|||.|.|.:|||.|||||:|...||:|||:|.
 Frog  1317 LKRQLEEETKAKNALAHGLQSARHDCDLLREQYEEEQEAKGELQRSLSKANSEVSQWRTKYETDA 1381

  Fly  1379 VARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443
            :.|:|||||||:||..||.||||.||::|.||..||||||||..|||||.::|:|:|:...|.:|
 Frog  1382 IQRTEELEEAKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQNEVEDLMVDVERSNSACAALDK 1446

  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEV 1508
            |||.|||::.:||.|.::..|||:|||||.|:.|||:|::|.:|||..:|||.::||||||..|:
 Frog  1447 KQKNFDKVLADWKQKFEESQAELEASQKESRSLSTEVFKMKNSYEEALDQLETLKRENKNLQQEI 1511

  Fly  1509 KDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR 1573
            .||.:||.|.|:.|||||||:|::|.||.:||:||||||.:||.||.||||.||||:||:.|:||
 Frog  1512 SDLTEQIAESGKTIHEIEKAKKQIEQEKSDLQSALEEAEGSLEHEEAKVLRIQLELNQVKGEVDR 1576

  Fly  1574 RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEA 1638
            :|.||:||.|..::|.||||:|||::|:||.:.:.:|||:|||:|.|:||:||.|.|||:..||:
 Frog  1577 KIAEKDEEIEQLKRNSQRALESMQSTLDAEIRSRNDALRLKKKMEGDLNEMEIQLSHANRQAAES 1641

  Fly  1639 QKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ 1703
            ||.::..|..|||.|..|::.||..||.:|||.|.|||.|.:..|:||.|:.|||.:|||:.|||
 Frog  1642 QKQLRNVQGLLKDTQLHLDDAQRGNDDLKEQLAIVERRNNLMTAEIEEMRSALEQTERGRKVAEQ 1706

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADEL 1768
            ||.|..|::..:.:||.|:...|:|:||::..|.|:::|.:.||:|::||||||:.|||.:|:||
 Frog  1707 ELIDVTERVQLLHSQNTSLINTKKKIESDVSQLQSEVEEAVQEARNADEKAKKAITDAAMMAEEL 1771

  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            :.|||.:...|:::|.|||.:|:||.||||||..|:|||||.:||||.||||||||||.||:|.:
 Frog  1772 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLEARVRELENELDAEQKRGS 1836

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898
            ||.|.:||.||||||||:|||||:||..|:||||||||.|:||||||.|:.||.|.::|::||||
 Frog  1837 DAIKGVRKFERRVKELSYQSEEDKKNVFRLQDLVDKLQLKVKTYKRQTEDIEEQANVHLSRFRKA 1901

  Fly  1899 QQELEEAEERADLAEQAISKFRAKGRAGSVGRGA 1932
            |.||||||||||:||..::|.|||.|  .:|:.|
 Frog  1902 QHELEEAEERADIAESQVNKLRAKSR--DIGKKA 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 7/36 (19%)
MYSc 81..777 CDD:214580 452/702 (64%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 431/671 (64%)
Myosin_tail_1 842..1897 CDD:279860 559/1054 (53%)
V_Alix_like 1557..1877 CDD:187408 180/319 (56%)
ATP-synt_B <1671..1771 CDD:304375 47/99 (47%)
TMPIT 1739..>1825 CDD:285135 50/85 (59%)
LOC100493121XP_012809641.1 Myosin_N 35..72 CDD:280832 7/36 (19%)
Myosin_head 87..768 CDD:278492 440/683 (64%)
Motor_domain 99..768 CDD:277568 431/671 (64%)
Myosin_tail_1 848..1925 CDD:279860 577/1076 (54%)
RILP-like 963..1096 CDD:304877 63/132 (48%)
DUF342 <1154..1239 CDD:302792 51/84 (61%)
MIT_CorA-like <1297..>1409 CDD:294313 60/111 (54%)
COG6 1374..>1535 CDD:303003 94/160 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1116 1.000 Domainoid score I21
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2089 1.000 Inparanoid score I44
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm48957
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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