DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhc and myo15b

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_031750066.1	Gene:	myo15b / 100485698	XenbaseID:	XB-GENE-6045939	Length:	3748	Species:	Xenopus tropicalis

Alignment Length:	825	Identity:	228/825 - (27%)
Similarity:	409/825 - (49%)	Gaps:	75/825 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLI 115
            |.:.:..|::.:.:...:||.        .:.|:.|::.|:..:..:....||..|::|::....
Frog  1298 EAEDSSEDMLQMSMNKKQVRG--------ADCPEAEEVSDLCFLKDVCESAVLLCLKRRFHRNET 1354

  Fly   116 YTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGE 180
            ||:.|...:::||.|...:::...|::|......|.||||||:::.||....|:.|..::|::|.
Frog  1355 YTHVGHMLLSMNPGKALNIHSPDMAQVYWDGESVEKPPHIFAVAEDAYSLSQTSDVAPNILLSGH 1419

  Fly   181 SGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTN---PVLEAFGNAKTVRNDNSSR 242
            ||:||:|..|.:..|..|:...:            |::::|..   .|||:|||||||.||||:|
Frog  1420 SGSGKSEAVKLMALYLVTLSTRQ------------EEKILQLEDFLKVLESFGNAKTVFNDNSTR 1472

  Fly   243 FGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIY 307
            ||:.::::. .:|.:.|..:..:||||:||:.|...||.:|:||:::.| :|..:...|......
Frog  1473 FGQVLQLYL-HSGAVVGGMVSPFLLEKSRVVFQAQGERGFHVFYELLRG-LPAHEKQRLYLQEPE 1535

  Fly   308 DYHIVSQGKV-TVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQ 371
            .|:.::||:. .|...:|.::|.|..:....:|.:..|...::.:.:|::.:|.:.|
Frog  1536 TYYYLNQGRACDVRGKNDKQDFVLLGKCLRAIGLSFTELTAIWAVLSAILQLGNICF-------- 1592

  Fly   372 AEQDGEEEGGRVSKLFGCDTAELYKNLLK-----------PRIKVGN-EFVTQGRNVQQVTNSIG 424
              ...|::...::..|......:..:||:           .|:.|.: :.|....:|:...:...
Frog  1593 --SSCEKDSFGLAAAFSATEVRIVASLLQISPEGLQRAITQRVTVTSYDRVLSPLSVEASIDVRD 1655

  Fly   425 ALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFN 489
            |:.:.::..||.||::|.|..|. .||....:|::|:.|||....|..||||.|:.||.:|.:..
Frog  1656 AISQTLYSLLFNWLLEKGNSWLH-PQKMDKTLGIVDVCGFENLGVNSLEQLCRNYANEHIQHYSK 1719

  Fly   490 HHMFVLEQEEYKREGIDWAFIDFGMDLLA-CIDLI-EKPMGILSILEEESMFPKATDQTFSEKLT 552
            ..:.:.||.||.|||:.|  :....:.:. |:.|: |.|.||..:|||:|...:|||.||.:| .
Frog  1720 QRLVIQEQAEYAREGLRW--VPLNQESVGPCLGLLTEPPHGIFHMLEEQSSLAQATDHTFLQK-C 1781

  Fly   553 NTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLL 617
            :.|.|.|..:.|||.|.|     .|.:.||||.|:|.:..:|.||:|.|.....:...:|:.:||
Frog  1782 HYHHGNSGCYIKPKLPLP-----VFTLQHYAGPVTYQVHNFLNKNRDRLPAAATEVLSQSRLRLL 1841

  Fly   618 IEIFADHAGQSGGGEQAKGGRGKKGGGFA---TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEM 679
            .|:|.    ||....|.     |:||..|   |::..::..|..|.:.|...:..|||||.||..
Frog  1842 SELFT----QSRSSNQQ-----KEGGALAKELTLTGRFQASLQELTSCLERGRTLFVRCIAPNPK 1897

  Fly   680 KQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEII 744
            :..|:.|...|..||..:|:||.:::.::|:|.|:...||..||..:...........:..|.::
Frog  1898 QLRGIFDVDFVSSQLRNSGILETVQLMKEGYPIRIPLKDFVARYGYLVRSSASFANDQECCTAVL 1962

  Fly   745 IKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVA 809
            .|.:......|::|.:|||.:......::.:.|.........:|...||:|:||.|   |..|..
Frog  1963 TKAVGDASKLYQIGLSKVFLKEEGKEMLQGYLDVIRRHAAITLQRNLRGFLNRKNF---QVYRNK 2024

  Fly   810 LKVVQRNLRKYLQLRTWPWYKLWQ-KVKPLLNVSRIEDEIARLEE 853
            :.|:|.::|.:...|.:...|..: ::..:|.:|::..:..:|:|
Frog  2025 ITVIQAHVRGHQARRRYRQLKHTRVQLGAVLLISKVHSKHLKLKE 2069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	4/21 (19%)
		MYSc	81..777	CDD:214580	205/716 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	202/685 (29%)
		Myosin_tail_1	842..1897	CDD:279860	3/12 (25%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo15b	XP_031750066.1	PTZ00108	<45..273	CDD:240271
		MSCRAMM_ClfA	<372..704	CDD:411231
		UBAN	<800..861	CDD:417685
		Motor_domain	1339..1983	CDD:419868	202/685 (29%)
		IQ	2022..2042	CDD:197470	5/19 (26%)
		MyTH4	2147..2296	CDD:413333
		SH3_MYO15B	3146..3200	CDD:213001
		MyTH4	3342..3440	CDD:395633
		B41	3449..3650	CDD:214604
		PH-like	3647..3743	CDD:418428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000