DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myo5b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_031750785.1 Gene:myo5b / 100379760 XenbaseID:XB-GENE-988439 Length:1835 Species:Xenopus tropicalis


Alignment Length:2072 Identity:552/2072 - (26%)
Similarity:894/2072 - (43%) Gaps:490/2072 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGE-IKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIE------ 89
            |......||||.::.:...| ||..|....|:.|: .|...:...:|:..|.|.....:      
 Frog     7 YSQYTRVWIPDPEDVWRSAEIIKDYKEGDKSLQLK-LEDESVIQHRVDPNNLPHLRNPDILVGEN 70

  Fly    90 DMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPP 153
            |:..::.|:.|.|||||:.|:. :..||||.|:..||||||::.|||.......|.|:...::.|
 Frog    71 DLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYQQLPVYGEDVIYAYSGQNMGDMDP 135

  Fly   154 HIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQ 218
            ||||:::.||..|..:..|||::::||||||||.:.|..:.||||||.|       .|:.::|::
 Frog   136 HIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------ASEANVEEK 193

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            |:.::|::||.|||||.||||||||||:|:|.|.....:.||::.||||||:||:.|..:||:||
 Frog   194 VLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADMERNYH 258

  Fly   284 IFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQEKE 346
            ||||: .|.|:|...::.|.....:.|  .:| |...:..:||||:|..|.|||.:||..:..:.
 Frog   259 IFYQLCASASLPEFSELSLAEAEEFFY--TNQGGDPVIDGVDDAEDFEKTRQAFTLLGVKETHQM 321

  Fly   347 DVYRITAAVMHMGGMKFKQRGREEQAEQDGE----EEGGR----VSKLFGCDTAELYKNLLKPRI 403
            .:::|.|:::|:|.:..       |.|::||    .:|.:    ...|.|.:..::...|...::
 Frog   322 GIFKIVASILHLGNVAI-------QTEREGESCNLSKGDKHLTHFCSLLGLEQDQMQHWLCHRKL 379

  Fly   404 KVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468
            ...:|...:..:.:|..|:..||.|.::.:||.|:|:..|:.|.|..|:..|||||||.|||.||
 Frog   380 VTTSETYVKTMSAEQAVNARNALAKHIYAQLFNWIVQHVNKALHTTIKQHSFIGVLDIYGFETFE 444

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSIL 533
            .|.|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||||||..:|||.:|
 Frog   445 INSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLL 508

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNK 598
            :||...||.|||.:::||.:.| |.|..|:||:     .....|.:.|:|..|.|...|:||||:
 Frog   509 DEECKVPKGTDQNWAQKLYDRH-GSSQHFKKPR-----MSNVAFIVVHFADQVEYQCDGFLEKNR 567

  Fly   599 DPLNDTVVDQFKKSQNKLLIEIF---------------------ADHAGQSGGGEQAKGGRGKKG 642
            |.:.:..::..|.|:..|:.::|                     |..|.:|...|..|       
 Frog   568 DTVYEEQINILKASKYPLVADLFQNEKDTVPPTPTGKSKISVRPAKPALKSANKEHKK------- 625

  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707
                ||...::..|:.||.||.:|.||:||||.||:.|:....|....:.||...||||.|||..
 Frog   626 ----TVGHQFRNSLHLLMETLNATTPHYVRCIKPNDYKESFSFDPKRAVQQLRACGVLETIRISA 686

  Fly   708 KGFPNRMMYPDFKMRY--------------KIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLG 758
            .|:|:|..|.||..||              |::|..:|:.:.||              .|:::.|
 Frog   687 AGYPSRWTYHDFFNRYRVLMKKKDISLGDKKVICKNVLENLIKD--------------PDKFQFG 737

  Fly   759 NTKVFFRAGVLGQMEEFRDE--RLGKIM------SWM---------------QAWARGYLSR--- 797
            .||:|||||.:..:|:.|.:  |...||      .|:               |.:.||:|:|   
 Frog   738 RTKIFFRAGQVAYLEKLRADKFRAATIMIQKTVRGWLQRVKYRRMKKAAVTIQRYTRGHLARRLA 802

  Fly   798 ----------------------KGFKKLQEQRVALKVVQRNL---RKYLQL-------------R 824
                                  :||:|.::..|.::...|.:   |.|.||             |
 Frog   803 LHLRMTKAAITFQKQFRMIRVYRGFQKTRKAAVTIQSYTRGMFVRRAYRQLLEQHKAAIIQKHWR 867

  Fly   825 TWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDS 889
            .|...||:.|.:                 .|....:.:...:|.|:||:.|.   :..:||    
 Frog   868 GWRARKLFSKFR-----------------SAAVVIQCYFRRMKARRELKQLK---IEARTA---- 908

  Fly   890 LSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERL----TQEEDARNQLFQQKKKADQEISGLK 950
                        |...||:.   .:||::..:|.:|    .:::|.:.||.........|:..|:
 Frog   909 ------------EHFKKLSV---GMENKVVQLQRKLDEQNKEQKDLKEQLVSATSTHAVEVEKLQ 958

  Fly   951 KDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDK 1015
            |::|    ..::|:||    ::|:.:|..|:....|.:.|...|||:..:|              
 Frog   959 KELE----KQRQAQQD----ENQLTSLQQELEALREELAKAYSEKKVVEDT-------------- 1001

  Fly  1016 INHLNKVKAKLEQTLDELED---SLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQ 1077
               |...|.:|.|.:.|||:   :|:.||      |:...|:             :.|::.|..|
 Frog  1002 ---LMNEKEQLLQRVSELEEENTNLKEEK------EELSNKI-------------ILRSEDEFTQ 1044

  Fly  1078 TIQRKDKELSSITAKLEDEQVVVLKHQRQIKE---LQARIEELEEEVEAERQA----RAKAEKQR 1135
            :..:::.|   |...||:|:   .:||..:||   |:.|.:.|:|||...:|.    |.....|.
 Frog  1045 STIKENLE---IKKDLEEER---SRHQNLVKEYTRLEQRYDNLKEEVNIIKQQMPGHRRNPSNQS 1103

  Fly  1136 A-------------------DLARELEELGERLEEAGGATSAQIELNKK-REAEL--SKLRRDLE 1178
            :                   |..:|:||.|  ||:|....|..::|.|: ||.||  .||:..|:
 Frog  1104 SLESDSNYPSISTSEIGDTEDTIKEVEEAG--LEKAAMDMSLFLKLQKRVRELELERKKLQSQLD 1166

  Fly  1179 EANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAA 1243
            :.. |.|:..:.:....|:.:|:....: ..|.||.:..:.:|                      
 Frog  1167 KKE-QQENKKSQVIDTTNEVIADRDTDI-AYNNLKRQELESEN---------------------- 1207

  Fly  1244 QEKIAKQLQHTLNEVQSKLDETNRTLND--FDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306
                 |:|::.|||::       :|:.|  .|.|.::..|  :.||.||:.|..::....:..:.
 Frog  1208 -----KKLKNDLNEMR-------KTIADGAVDGSSEEARI--AMLLNQLKSAHEELDVRKEEVLM 1258

  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371
            |.||:  .|....:||....:....:.|...::|      |::|   .:....:.:.|.:.|.| 
 Frog  1259 LRTQI--VKAAQQKESERIMSSEASWPNSNKEMD------EDDA---IEAYHGVCETNRKTQDW- 1311

  Fly  1372 SKYESDGVARSEELEEAKRKLQ--ARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRA 1434
            .....||     ||..|.:.|:  |||.||:            |:...::...|||.|...:|  
 Frog  1312 GYLNEDG-----ELGLAYQGLKQVARLLEAQ------------LQAQSRQHDEEVEILTSHID-- 1357

  Fly  1435 NAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRR 1499
             ::....||:|:..        |:...|:.|                    |..|...|.|..|.
 Frog  1358 -SLKEELEKQQQVL--------LQALQLSPE--------------------AQVEFGLQHEITRL 1393

  Fly  1500 ENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLEL 1564
            .|:||  ::|:||:          :.||..|:|:.:........:::|..::.|....|..|:.:
 Frog  1394 TNENL--DLKELLE----------KSEKNEKKLKKQLKTYMKKGQDSEDVVQTERKPELTRQVTV 1446

  Fly  1565 SQVRQEIDRRIQEKEEEFENTRKN-----HQRALDSMQASLEA--------EAKGKAEALRMKKK 1616
            .::.::....::..:||.....:|     ....:.||...|.|        .|....:..::...
 Frog  1447 QRIEKDFQGMLEYYKEEEPLLVRNLIIDVKPEQMSSMVPCLPAYILFMCIRHADYINDDQKVHSL 1511

  Fly  1617 LEADINELEIALDHANKANAEAQ------KNIKRYQQQLKDIQTALEEEQRARDDAREQLGISER 1675
            |.:.||.::..|   .|.::|.|      .|..|....||         |.:.|:........::
 Frog  1512 LTSTINGIKKVL---KKHHSEFQITSFWLSNSSRLLHCLK---------QYSGDEGFMTSNSPKQ 1564

  Fly  1676 RANALQN-ELEESRTLLEQADRGRRQAEQELADAHEQLNEVSA--QNASISAAKRKLESELQTLH 1737
            ..:.|:| :|.|.|.:|........|...::|:.|.|...|||  :..||..    |....||.:
 Frog  1565 NEHCLRNFDLTEYRQVLSDLSIQIYQQMIKIAETHMQPMIVSAMLETESIQG----LSGVKQTGY 1625

  Fly  1738 SDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEAN 1802
            ......:.:..||  .:.:|::......:.:..  ||....|    .::|..|:|...::....|
 Frog  1626 RKRTSSMADGDNS--YSLEAVIRQLNTFNSIMC--DHGLDPE----IIQQVFKQLFYMINAVTLN 1682

  Fly  1803 ALKGGKKAI-----QKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHER 1862
            .|...|...     .:|...:.:||..|.|         |||..|...               :.
 Frog  1683 NLLLRKDVCSWSTGMQLRYNISQLEEWLRG---------KNLHPSGAA---------------QT 1723

  Fly  1863 MQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLA 1912
            |:.|: :..|.::..|:..|:||.|.:|       .:.|.......:.|.|||..::
 Frog  1724 MEPLI-QAAQLLQLKKKTEEDAEAICSLCTALTTQQIVKILNLYTPVNEFEERVTVS 1779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/37 (30%)
MYSc 81..777 CDD:214580 278/747 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 269/710 (38%)
Myosin_tail_1 842..1897 CDD:279860 233/1128 (21%)
V_Alix_like 1557..1877 CDD:187408 65/346 (19%)
ATP-synt_B <1671..1771 CDD:304375 21/102 (21%)
TMPIT 1739..>1825 CDD:285135 15/90 (17%)
myo5bXP_031750785.1 MYSc_Myo5 81..744 CDD:276831 269/710 (38%)
IQ 758..780 CDD:197470 4/21 (19%)
IQ 781..800 CDD:197470 4/18 (22%)
IQ 855..875 CDD:197470 3/19 (16%)
Smc 895..>1217 CDD:224117 95/424 (22%)
Smc 1123..>1458 CDD:224117 96/446 (22%)
Myo5b_CBD 1461..1832 CDD:271261 74/368 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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