DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and LOC100329748

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_021326089.1	Gene:	LOC100329748 / 100329748	-ID:	-	Length:	1940	Species:	Danio rerio

Alignment Length:	1918	Identity:	1065/1918 - (55%)
Similarity:	1422/1918 - (74%)	Gaps:	10/1918 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |||..|.::|...|::|:|.||.|::||..|.||...:.:..||.|:..........:|...|..
Zfish    14 PYLRKSDKERLEAQTRPFDMKKECFVPDADEEYLKATVISRDGDKVTCETSKKTTVTVKECDVHP 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||..|.|:.|.||.||::||.|.:||||||||||.:||||..|||.......||
Zfish    79 QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA-SKKTDEA 208
            ||:|:|.|||||:|||.||..||::..|||:|||||||||||.|||:||.|||::.| |.|.|.:
Zfish   144 GKKRSEAPPHIFSISDNAYQYMLSDRENQSILITGESGAGKTVNTKRVIQYFASIAAGSSKKDSS 208

  Fly   209 AKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVI 273
            ::.||:||||::|.||.|||||||||:||||||||||||||||..:||||.||||||||||:||.
Zfish   209 SEKKGTLEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFAASGKLASADIETYLLEKSRVT 273

  Fly   274 SQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDIL 338
            .|...||.|||||||:|...|.:.::.|:|.|.|||..:|||:..||||||::|...||:|||:|
Zfish   274 FQLKAERDYHIFYQILSQKKPELLEMLLITANPYDYAFISQGETQVASIDDSDELMATDEAFDVL 338

  Fly   339 GFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI 403
            |||::||..:|::..|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..||:
Zfish   339 GFTQEEKNSIYKLIGAIMHYGNMKFKQKQREEQAEADGTEDADKSAYLMGLNSADLIKALCHPRV 403

  Fly   404 KVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468
            |||||:||:|:|||||..:||||.|.|::::|.|:|.:.|::|||:|.||:|||||||||||||:
Zfish   404 KVGNEWVTKGQNVQQVYYAIGALSKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFD 468

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSIL 533
            :|.||||||||||||||||||||||||||||||:|||||.||||||||.||||||||||||:|||
Zfish   469 FNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIDLIEKPMGIMSIL 533

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNK 598
            |||.|||||:|.||..||.:.|||||..||||:..| |:..|||::.||||.|.|||..||.|||
Zfish   534 EEECMFPKASDATFKAKLYDNHLGKSNNFQKPRIVK-GKPEAHFSLVHYAGTVDYNINNWLVKNK 597

  Fly   599 DPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG----KKGGGFATVSSAYKEQLNSL 659
            ||||:|||..::||..|||..:||.:||.....:...||:|    |||..|.|||:.::|.||.|
Zfish   598 DPLNETVVGLYQKSTMKLLSNLFAGYAGAESAADGGGGGKGKEKKKKGSSFQTVSALHRENLNKL 662

  Fly   660 MTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYK 724
            ||.||||.|||||||||||.|.||.::..||||||.||||||||||||||||||::|.|||.||:
Zfish   663 MTNLRSTHPHFVRCIIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYR 727

  Fly   725 IMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW 786
            |:.|..:   |.:: .:|..|.::..:|:..:|||.|:|||||:||:||.:||.||:||..|::.
Zfish   728 ILNPAAIPEGQFID-SRKGAEKLLGSLDIDHNQYRFGHTKVFFKAGLLGTLEEMRDDRLALIITG 791

  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851
            :||.|||.|||..|:|:.::|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.:
Zfish   792 IQARARGILSRIEFQKIVDRRDALLVIQWNVRAFMGVKNWPWMKLYFKIKPLLRSAEAEKEMANM 856

  Fly   852 EEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
            :|:..|.:|.:|.....|||||.....||.||..|..::..|:..|.|.:||...|...|..||.
Zfish   857 KEEFLKLKEAYAKSEARRKELEEKMVSLLQEKNDLQLAVQSEQDNLCDAEERCEGLIKNKIQLEA 921

  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981
            :.:::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:
Zfish   922 KAKELTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 986

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
            |..||:|.||.||||...|.:|:|.::||:.|||:|.|.|.||||||.:|:||.|||:|||:|.|
Zfish   987 AALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMD 1051

  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQ 1111
            :|::|||:|||||||||:|.|||.:|::||:.:::||.|:|.:::::||||.:..:.|:::||||
Zfish  1052 LERAKRKLEGDLKLTQESVMDLENDKQQLEERLKKKDFEISQLSSRIEDEQAMAAQLQKKLKELQ 1116

  Fly  1112 ARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRD 1176
            |||||||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..|||||
Zfish  1117 ARIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRD 1181

  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241
            ||||.:|||:|.:.|||||.|:|:::.||:|.|.::|.|.||||:|...:|:|:.:.::.|...|
Zfish  1182 LEEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAK 1246

  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306
            |..||:.:.|:..::|.::|.:|..|::|||...|.||..||.:|.|||||.:|.||||::.|.|
Zfish  1247 ANLEKMCRTLEDQMSEYRTKYEEAQRSINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQS 1311

  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371
            .|.|:||.:|..:||.:.:..|....::..||.:.||||.|||.|.||:|||.|||||:|...||
Zfish  1312 YTQQIEDLRRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWR 1376

  Fly  1372 SKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANA 1436
            :|||:|.:.|:||||:||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:||
Zfish  1377 TKYETDAIQRTEELEDAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1441

  Fly  1437 IANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501
            .|.|.:|||:.|||::.|||.|.::..:||::||||.|:.|||||:||.:|||..:.||:::|||
Zfish  1442 AAAALDKKQRNFDKVLAEWKQKYEESQSELESSQKEARSLSTELFKLKNSYEESLDHLESMKREN 1506

  Fly  1502 KNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ 1566
            |||.:|:.||.:||||.|:||||:||.||:||.||.|:|.||||||.:||.||.|:||||||.:|
Zfish  1507 KNLQEEIADLTEQIGESGKNIHELEKIRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQ 1571

  Fly  1567 VRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHA 1631
            |:.:|:|::.||:||.|..::|.||.:|::|:|||:|.:.:.||||:|||:|.|:||:||.|..|
Zfish  1572 VKADIERKLSEKDEEMEQAKRNQQRMIDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQA 1636

  Fly  1632 NKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADR 1696
            |:..:||||.:|.....|||.|..|::..|..||.:|.:.|.|||.|.||.||:|.|:|:||.:|
Zfish  1637 NRQASEAQKQLKGLHGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTER 1701

  Fly  1697 GRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA 1761
            ||:.|||||.|..|::..:.:||.|:...|:|||.:...|.::::|.:.|.:|:|||||||:.||
Zfish  1702 GRKLAEQELMDVSERVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITDA 1766

  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826
            |.:|:||:.|||.:...|:::|.:||.||:||.||||||..|:|||||.:||||.||||||:|::
Zfish  1767 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEVE 1831

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALN 1891
            .|||:.:::.|.:||.|||:|||::|:||||||..|:||||||||.|:|:|||..|||||.|..|
Zfish  1832 MEQRKASESVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRAAEEAEEQANSN 1896

  Fly  1892 LAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.||||.|.||:|||||||:||..::|.|||.|
Zfish  1897 LGKFRKLQHELDEAEERADIAESQVNKLRAKSR 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/36 (28%)
		MYSc	81..777	CDD:214580	440/703 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	420/672 (63%)
		Myosin_tail_1	842..1897	CDD:279860	553/1054 (52%)
		V_Alix_like	1557..1877	CDD:187408	166/319 (52%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
LOC100329748	XP_021326089.1	Myosin_N	34..72	CDD:308391	11/37 (30%)
		MYSc_class_II	99..770	CDD:276951	420/672 (63%)
		SMC_N	850..1927	CDD:330553	569/1076 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1098	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	2094	1.000	Inparanoid score	I40
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24867
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.970