DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo1e.1

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001121497.2	Gene:	myo1e.1 / 100158599	XenbaseID:	XB-GENE-1005591	Length:	1108	Species:	Xenopus tropicalis

Alignment Length:	1023	Identity:	312/1023 - (30%)
Similarity:	506/1023 - (49%)	Gaps:	147/1023 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148
            |...::||..::.:....::.||::||....|:||.|...:::||:|:.|.:.::..:||:|..:
Frog    17 KHSGVDDMVLLSKITEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQMPYFGDKEIEMYQGAAQ 81

  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSK 212
            .|.||||:|::|..|.:|:.:..||.::|:||||||||...|.:::|.:.| |...|...
Frog    82 YENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISKVSGGGPKVQH----- 141

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
              ::|.::|:||:||||||||||||:|||||||:..|.|.|.|:..|..|..:||||:||:.:..
Frog   142 --VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNP 204

  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            .|||:|||||::.|:....::...:|...|..::...|...|..|:|..:|..|..|.:::|.:.
Frog   205 GERSFHIFYQLIEGASKDQRESLGITSLDYYNYLNQSGSYKVDDINDKRDFQETMHAMNVIGISA 269

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI--KV 405
            :.:..|.:|.|.|:|:|.:.||::|  ..|..:.||.....:.|.|.:.:.|...|...::  |.
Frog   270 EGQAMVMQIVAGVLHLGNIGFKEKG--NYAAVENEEFLAFPAFLLGINQSRLKDKLTSRQMDSKW 332

  Fly   406 G--NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468
            |  :|.:....||:|...:..||.|.:..|:|.:||...|:.: .:...::.||||||.|||||:
Frog   333 GGKSESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAM-KKDHEEYNIGVLDIYGFEIFQ 396

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE---KPMGIL 530
            .|||||.||||.||||||.|.......|||||.:|||.|..|::..:.:.| ||||   .|.|::
Frog   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVC-DLIENKVNPPGVM 460

  Fly   531 SILEEESMFPKA----TDQTFSEKL-----TNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCV 586
            |||::......|    .|||..:||     |:.|...            ..|.  |.|.||||.|
Frog   461 SILDDVCATMHAVGEGADQTLLQKLQMAVGTHEHFNS------------WNQG--FIIHHYAGKV 511

  Fly   587 SYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSA 651
            ||::.|:.|:|:|.|...:::..:.||...:..:|.::.            :.:|.|...|..|.
Frog   512 SYDVDGFCERNRDVLFMDLIELMQSSQQPFMQALFPENL------------QAEKKGRPTTAGSK 564

  Fly   652 YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMY 716
            .|:|.|.|:.||....||::|||.|||.|:|...:...|.||:...|:.|.||:.|.|:..|.::
Frog   565 IKKQANDLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVF 629

  Fly   717 PDFKMRYKIMCPKLLQGVEKD-KKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEEFRDER 779
            ..|..||.|:..:.....:.| ||....::..:::..||::||.||:|.:| ..|..:||.|:.:
Frog   630 KKFLQRYAILTKETWPSWKGDEKKGVLHLLHSVNMDSDQFQLGKTKIFIKAPESLFLLEEMRERK 694

  Fly   780 L-GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRK----------YLQLRTWPWYKLWQ 833
            . |...|..:|| |.|::||.:.:::||...|.:.::..|:          |:.:
Frog   695 YDGYARSIQKAW-RKYVARKKYVQMREQASDLFLNKKERRRNSINRNFIGDYIGM---------- 748

  Fly   834 KVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAK---LLAEKTALL---DSL-- 890
                        ||...|.:...|.|::..|:...:.:..:...|   :|..|:..|   |.:
Frog   749 ------------DERPELRQFVGKREKIDFADTVTKYDRRSKGVKRDLILTPKSVYLIGRDKMKQ 801

  Fly   891 SGEKGALQDYQERNAKLTAQKNDLEN----QLRDIQERL----TQEEDA-RNQLFQQKKKADQEI 946
            ..|||.:::       :..:|.|:|.    .|..:|:..    .||.|: ...||:     .:.|
Frog   802 GPEKGLVKE-------VLKKKIDVERILSVSLSTMQDDFFILHEQEYDSLLESLFK-----TEFI 854

  Fly   947 SGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEK--KMQGETNQKTGEEL 1009
            |.|.|..|      :|.::....|.:.|.::            ||.||.  ...|....:..:.:
Frog   855 SLLSKHYE------EKTQRKLPLKFNNILDM------------KLKKENWGPWSGGAGSRQVQFI 901

  Fly  1010 QAAED--KINHLNKV-KAKLEQTLDELEDSLEREKKV---RGDVEKSK 1051
            |...|  .:.|.:|| :..:.|.|.  ::|....:.:   ||:..|||
Frog   902 QGFGDLAVLKHSSKVLQVSIGQGLP--KNSRPTRRNITNGRGNASKSK 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	248/711 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	241/682 (35%)
		Myosin_tail_1	842..1897	CDD:279860	50/235 (21%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo1e.1	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	241/682 (35%)
		Myosin_TH1	719..921	CDD:368706	47/253 (19%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910