Protein Alignment Mhc and myha

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_021332193.1
• Gene: myha / 100149148
• ZFINID: ZDB-GENE-060531-50
• Length: 1933
• Species: Danio rerio
• Alignment Length: 1913
• Identity: 1061/1913 - (55%)
• Similarity: 1416/1913 - (74%)
• Gaps: 18/1913 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSV-GLQGGETRDLKKDLLQQVNPPK 84
            |:.||: |:||:|:|.:|::.|:||.|:.|.||:..|..|:| .|...|.|..|::.:..:||||
Zfish    21 EKERIEAQNKPFDAKSACYVVDDKELYVKGTIKSRDGGKVTVITLDTKEERVAKEEDVHPMNPPK 85

  Fly    85 YEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            ::|.|||:.:|:||:.|||:||::||...:|||||||||..:||||..|||.......||||:|.
Zfish    86 FDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRM 150

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV----GASKKTDEAAK 210
            |.|||||::||.||..|||:..|||:|||||||||||.|||:||.|||||    |..||.....|
Zfish   151 EAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQTPGK 215

  Fly   211 SKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQ 275
            .:||||||::..||:|||:|||||||||||||||||||||||.|||||.||||||||||:||..|
Zfish   216 MQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQ 280

  Fly   276 QSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGF 340
            ...||.||||||:|:...|.:.::.|:|.|.||:.:.|||::|||||||.||...||.|.|||||
Zfish   281 LPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGF 345

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            |.:||..:|:.|.||:|.|.|||||:.||||||.||.||..::|.|.|.::||:.|.|..||:||
Zfish   346 TGEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKISYLLGLNSAEMLKALCYPRVKV 410

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ||||||:|:.|.||.||:.||.|.:::|:|.|:|.:.|:.|||:|:|..|||||||||||||::|
Zfish   411 GNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNFFIGVLDIAGFEIFDFN 475

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEE 535
            ..||||||||||||||||||||||||||||::|||.|.||||||||..||:||||||||.|||||
Zfish   476 SMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPMGIFSILEE 540

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |.|||||||.:|..||.:.||||...||||:|.| |:..|||::.||||.|.||::|||:|||||
Zfish   541 ECMFPKATDTSFKNKLYDQHLGKCNAFQKPRPQK-GKAEAHFSLVHYAGTVDYNVSGWLDKNKDP 604

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            ||::||..::||..|||..::......:    ..|||: ||||...||||.::|.|..|||.|||
Zfish   605 LNESVVQLYQKSSVKLLATLYPPVVEDT----SKKGGK-KKGGSMQTVSSQFRENLGKLMTNLRS 664

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            |.||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...:
Zfish   665 THPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 729

  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            :   |.:: :|||:|.::..||:..|:||.|:|||||:||:||.:||.|||:|..:::..||..|
Zfish   730 IPEGQFID-NKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCR 793

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK-AK 856
            .||.|:.|.|:.|:|.::..:|.|:|.::.::.|||.|::.|:||||..:..|.|:|.::|. .|
Zfish   794 AYLMRREFVKMMERRESIYTIQYNIRSFMNVKHWPWMKVYYKIKPLLKSAETEKELANMKEDFVK 858

  Fly   857 KAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            ..|:|..||.| :||||.....||.||..|..:::.|...|.|.:||...|...|..||.:|::.
Zfish   859 CKEDLVKAEAK-KKELEEKMVALLQEKNDLQLAVASEAENLSDAEERCEGLIKSKIQLEAKLKET 922

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|.|||
Zfish   923 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMASQDE 987

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::|
Zfish   988 SIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1052

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||.||::.|||.:|::.|:.|::||.|.|.:.:|:||||.:..:.|::||||||||||
Zfish  1053 RKLEGDLKLAQESIMDLENDKQQSEEKIKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEE 1117

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||||:.
Zfish  1118 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEST 1182

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:||..:::||.:.::.:...||..||
Zfish  1183 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEK 1247

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.|:..|:|::||.||..|.:||..|.:.:|..||.:..|||||.|:.||||::.|.:.|.|:
Zfish  1248 MCRTLEDQLSEIKSKSDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQI 1312

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:
Zfish  1313 EELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYET 1377

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||:|:||..||.||||.||::|.||..||||||||..|||||.::|:|||::|...
Zfish  1378 DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANSLAANL 1442

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:.:|||.|:.|||||::|.:|||..:|||.::||||||..
Zfish  1443 DKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1507

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:||||.|::|||:|||:|.:|.||.|:|.||||||..||.||:|:||.||||:||:.||
Zfish  1508 EISDLTEQIGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKGEI 1572

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||::.||:||.|..::|.||..::||::|::|.:.:.:|||:|||:|.|:||:||.|.|||:..|
Zfish  1573 DRKLAEKDEEIEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAA 1637

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.||||.|..|::..||::|.:||:.:.|||...:|:|:||.|..|||.:|||:.|
Zfish  1638 EAQKQLRNVQSQLKDAQLHLDDAVRAQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVA 1702

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|::..:.:||.|:...|:||||:|..:.|::::.:.||:|:|||||||:.|||.:|:
Zfish  1703 EQELVDASERVGLLHSQNTSLLNTKKKLESDLVQIQSEVEDTVQEARNAEEKAKKAITDAAMMAE 1767

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.||..:|:||.||||||..|:|||||.:||||.||||||:|:|.||||
Zfish  1768 ELKKEQDTSAHLERMKKNLEITVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEIDAEQRR 1832

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|:|.|
Zfish  1833 GADAVKGVRKYERRVKELTYQTEEDKKNINRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLR 1897

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.|.||||||||||::|..::|.|||.|
Zfish  1898 KVQHELEEAEERADISESQVNKLRAKSR 1925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	17/42 (40%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	411/671 (61%)
		Myosin_tail_1	842..1922	CDD:460256	580/1080 (54%)
myha	XP_021332193.1	Myosin_N	33..78	CDD:460670	17/44 (39%)
		MYSc_class_II	101..766	CDD:276951	411/671 (61%)
		Myosin_tail_1	846..1923	CDD:460256	580/1077 (54%)