DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and smyhc2

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001096096.2 Gene:smyhc2 / 100124599 ZFINID:ZDB-GENE-070822-12 Length:1939 Species:Danio rerio


Alignment Length:1927 Identity:1068/1927 - (55%)
Similarity:1432/1927 - (74%) Gaps:13/1927 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |:|..|.::|...|::|:|.||.|::||.:..|:...:.:..||.|:|..:.|:...:|......
Zfish    14 PFLRKSDKERLEAQTRPFDMKKECFVPDPEVEYVKASVTSRDGDKVTVETEFGKTVTVKEVDCHP 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||..|.|:.|.||.||::||.|.:||||||||||.:||||..|||.......||
Zfish    79 QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASK--KTDE 207
            ||:|.|.|||||:|||.||..||::..|||:|||||||||||.|||:||.|||::.|:.  |.|.
Zfish   144 GKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAAPGGKKDP 208

  Fly   208 AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARV 272
            :.:.||:||||::|.||.|||||||||:|||||||||||||||||.:|||:.||||||||||:||
Zfish   209 SQEKKGTLEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRV 273

  Fly   273 ISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDI 337
            ..|...||.|||||||:|...|.:.::.|:|:|.|||..:|||:..||||||.:|...||:|||:
Zfish   274 TYQLKAERDYHIFYQILSQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDV 338

  Fly   338 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPR 402
            ||||::||..:|::|.|:||.|.|||||:.||||||.||.|:..:|:.|.|.::|:|.|.|..||
Zfish   339 LGFTQEEKNSIYKLTGAIMHYGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPR 403

  Fly   403 IKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIF 467
            :|||||:||:|:|||||..|||||.|.|::::|.|:|.:.|::|||:|.||:|||||||||||||
Zfish   404 VKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIF 468

  Fly   468 EYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSI 532
            ::|.||||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||||:||
Zfish   469 DFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPMGIMSI 533

  Fly   533 LEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKN 597
            ||||.|||||:|.||..||.:.||||:..||||:..| |:..||||:.||||.|.|||:.||.||
Zfish   534 LEEECMFPKASDATFKAKLYDNHLGKNPNFQKPRIVK-GRPEAHFALVHYAGTVDYNISNWLVKN 597

  Fly   598 KDPLNDTVVDQFKKSQNKLLIEIFADHAG----QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNS 658
            |||||:|||..|:||..|||..:||::||    .|||  :.|||..|||..|.|||:.::|.||.
Zfish   598 KDPLNETVVGLFQKSTLKLLGTLFANYAGAESADSGG--KGKGGAKKKGSSFQTVSALHRENLNK 660

  Fly   659 LMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRY 723
            |||.||||.||||||:||||.|.||.::..||||||.||||||||||||||||||::|.|||.||
Zfish   661 LMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRY 725

  Fly   724 KIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMS 785
            :|:.|..:   |.:: :||..|.::..:|:..:||:||:|||||:||:||.:||.||:||..|::
Zfish   726 RILNPSAIPEGQFID-NKKGAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIIT 789

  Fly   786 WMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR 850
            .:||.|||.|||..|:|:.|:|.:|.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.
Zfish   790 GIQARARGILSRIEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMAN 854

  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE 915
            ::|:..|.:|.:|.....:||||.....||.||..|..::..|:..|.|.:||...|...|...|
Zfish   855 MKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFE 919

  Fly   916 NQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE 980
            .:::::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|
Zfish   920 AKVKELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 984

  Fly   981 IAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRG 1045
            :|..||:|.||.||||...|.:|:|.::||:.|||:|.|.|.||||||.:|:||.|||:|||:|.
Zfish   985 MAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKIRM 1049

  Fly  1046 DVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKEL 1110
            |:|::|||:|||||||||.:.|||.:|:::|:.:::||.|:|.:.:|:||||.:..:.|:::|||
Zfish  1050 DLERAKRKLEGDLKLTQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKLKEL 1114

  Fly  1111 QARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRR 1175
            ||||||||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||
Zfish  1115 QARIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRR 1179

  Fly  1176 DLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNE 1240
            |||||.:|||:|.:.|||||.|:|:::.||:|.|.::|.|.||||:|...:|:|:.:.::.|...
Zfish  1180 DLEEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKA 1244

  Fly  1241 KAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKI 1305
            ||..||:.:.|:..::|.::|.:|..||:|||...|.||..||.:|.|||||.:|.||||::.|.
Zfish  1245 KANLEKMCRTLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQ 1309

  Fly  1306 SLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVW 1370
            |.|.|:||.||..:||.:.:..|....::..||.:.||||.|||.|.||:|||.|||||:|...|
Zfish  1310 SYTQQIEDLKRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQW 1374

  Fly  1371 RSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRAN 1435
            |:|||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:|
Zfish  1375 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1439

  Fly  1436 AIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRE 1500
            |.|.|.:|||:.|||::.|||.|.::...||:::|||.|:.|||||:||.:|||..:.||:::||
Zfish  1440 AAAAALDKKQRNFDKVLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEESLDHLESMKRE 1504

  Fly  1501 NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELS 1565
            ||||.:|:.||.:|:||.|:||||:||.||:||.||.|:|.||||||.:||.||.|:||||||.:
Zfish  1505 NKNLQEEISDLTEQLGESGKNIHELEKVRKQLEQEKQEIQTALEEAEGSLEHEEGKILRAQLEFN 1569

  Fly  1566 QVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH 1630
            ||:.:|:|::.||:||.|..::|.||.:|::|:|||:|.:.:.||||:|||:|.|:||:||.|..
Zfish  1570 QVKADIERKLSEKDEEMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQ 1634

  Fly  1631 ANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQAD 1695
            ||:..:||||.:|.....|||.|..|::..|..||.:|.:.|.|||.|.||.||:|.|:|:||.:
Zfish  1635 ANRQASEAQKQLKGLHGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTE 1699

  Fly  1696 RGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVD 1760
            |||:.|||||.|..|::..:.:||.|:...|:|||.:...|.::::|.:.|.:|:|||||||:.|
Zfish  1700 RGRKLAEQELMDVSERVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITD 1764

  Fly  1761 AARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENEL 1825
            ||.:|:||:.|||.:...|:::|.:||.||:||.||||||..|:|||||.:||||.||||||:|:
Zfish  1765 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEV 1829

  Fly  1826 DGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL 1890
            :.|||:.:|:.|.:||.|||:|||::|:||||||..|:||||||||.|:|:|||..|||||.|..
Zfish  1830 EMEQRKASDSVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANS 1894

  Fly  1891 NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGA 1932
            ||.||||.|.||:|||||||:||..::|.|||.|.....:||
Zfish  1895 NLGKFRKLQHELDEAEERADIAESQVNKLRAKSRDSGSKKGA 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/36 (28%)
MYSc 81..777 CDD:214580 444/704 (63%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 424/673 (63%)
Myosin_tail_1 842..1897 CDD:279860 552/1054 (52%)
V_Alix_like 1557..1877 CDD:187408 167/319 (52%)
ATP-synt_B <1671..1771 CDD:304375 48/99 (48%)
TMPIT 1739..>1825 CDD:285135 49/85 (58%)
smyhc2NP_001096096.2 Myosin_N 35..72 CDD:280832 10/36 (28%)
Myosin_head 87..769 CDD:278492 431/685 (63%)
MYSc_class_II 99..769 CDD:276951 424/673 (63%)
Myosin_tail_1 849..1926 CDD:279860 568/1076 (53%)
RILP-like 964..1097 CDD:304877 66/132 (50%)
mycoplas_twoTM 1184..>1321 CDD:275320 62/136 (46%)
MIT_CorA-like <1298..>1410 CDD:294313 59/111 (53%)
COG6 1375..>1508 CDD:303003 73/132 (55%)
TMPIT 1458..>1563 CDD:285135 60/104 (58%)
TMPIT 1743..>1828 CDD:285135 49/84 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1098 1.000 Domainoid score I20
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68044
Inparanoid 1 1.050 2094 1.000 Inparanoid score I40
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm24867
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2660
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1212.000

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