DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myhz1.1l

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_017208743.1	Gene:	myhz1.1l / 100008376	ZFINID:	ZDB-GENE-200402-1	Length:	1936	Species:	Danio rerio

Alignment Length:	1911	Identity:	1070/1911 - (55%)
Similarity:	1428/1911 - (74%)	Gaps:	11/1911 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85
            |:.||: |:.|:|:|.:.::.|..|.||.|.:::.:|...:|....|:...:|.:::..:|||||
Zfish    20 ERERIEAQNTPFDAKTAYFVVDADEMYLKGTLQSKEGGKATVKTHSGKTVTVKEDEIFPMNPPKF 84

  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :||||||.||.||.||||:||::||.|.:||||||||||.:||||..|||.......||||:|.|
Zfish    85 DKIEDMAMMTHLNEPCVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDAIVVAGYRGKKRIE 149

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV----GASKKTDEAAKS 211
            .|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||||    ||.|:...|.|.
Zfish   150 APPHIFSISDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVGAMSGAKKQEPVAGKM 214

  Fly   212 KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            :||||||:|..||:|||:|||||||||||||||||||||||.|||||.||||||||||:||..|.
Zfish   215 QGSLEDQIVAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQL 279

  Fly   277 SLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341
            |.|||||||||:|:|..|.:.:..|:|.|.|||.::|||::||.||:|.|||..||.|.||||||
Zfish   280 SAERSYHIFYQLMTGHKPELLEALLITTNPYDYPMISQGEITVKSINDVEEFIATDTAIDILGFT 344

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            ..||..:|::|.||||.|.|||||:.||||||.||.|...:::.|.|.::|::.|.|..||:|||
Zfish   345 ADEKIAIYKLTGAVMHHGSMKFKQKQREEQAEPDGTEVADKIAYLMGLNSADMLKALCYPRVKVG 409

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG 471
            ||.||:|:.|.||.|::.||||.|::::|.|:|.:.||.|||:|.||.|||||||||||||::|.
Zfish   410 NEMVTKGQTVPQVNNAVSALCKSVYEKMFLWMVIRINEMLDTKQPRQFFIGVLDIAGFEIFDFNS 474

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEE 536
            .|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||||.||||||
Zfish   475 LEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEE 539

  Fly   537 SMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPL 601
            .|||||||.:|..||.:.||||.:.||||||.| |:..|||::.||||.|.|||.|||:||||||
Zfish   540 CMFPKATDTSFKNKLHDQHLGKCSAFQKPKPAK-GKAEAHFSLVHYAGTVDYNIVGWLDKNKDPL 603

  Fly   602 NDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRST 666
            ||:||..::||..|:|..::|.|.|::.||...|||: ||||.|.|||:.::|.|..|||.||||
Zfish   604 NDSVVQLYQKSSLKVLAFLYASHGGEAEGGGGKKGGK-KKGGSFQTVSALFRENLGKLMTNLRST 667

  Fly   667 QPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL 731
            .||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...::
Zfish   668 HPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASVI 732

  Fly   732 ---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARG 793
               |.:: :|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|..:::..||..||
Zfish   733 PEGQFID-NKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCRG 796

  Fly   794 YLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKA 858
            |:.||.|.|:.|:|.|:..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::|..:|.
Zfish   797 YVMRKEFVKMMERREAIYSIQYNIRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMAAMKENYEKM 861

  Fly   859 EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQE 923
            :|.....:..:||||.....||.||..|...::.|...|.|.:||...|...|..||.:|::..|
Zfish   862 KEDLTKALAKKKELEEKMVSLLQEKNDLQLQVASEGENLSDAEERCEGLIKSKIQLEAKLKETTE 926

  Fly   924 RLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELI 988
            ||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|.|||.|
Zfish   927 RLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMASQDESI 991

  Fly   989 NKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRK 1053
            .||.||||...|.:|:|.::|||.|||:|.|.|.|:||||.:|:||.|||:|||:|.|:|::|||
Zfish   992 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKSKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1056

  Fly  1054 VEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELE 1118
            :||||||.||::.|||.:|::.|:.|::||.|:|...:|:||||.:..:.|::||||||||||||
Zfish  1057 LEGDLKLAQESIMDLENDKQQSEEKIKKKDFEISQFLSKIEDEQSLGAQLQKKIKELQARIEELE 1121

  Fly  1119 EEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQ 1183
            ||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||||:.:|
Zfish  1122 EEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQ 1186

  Fly  1184 HESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIA 1248
            ||:|.|.||||..|:|||:.||:|.|.::|.|.||||:||..:::||.:.::.:...||..||:.
Zfish  1187 HEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMC 1251

  Fly  1249 KQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLED 1313
            :.|:..|:|:::|.||..|.|||.:|.:.:|..||.:..|||||.|:.||||::.|.:.|.|:|:
Zfish  1252 RTLEDQLSEIKTKSDENIRQLNDMNAQRARLQTENGEFSRQLEEKEALVSQLTRGKQAYTQQIEE 1316

  Fly  1314 TKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDG 1378
            .||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:|.
Zfish  1317 LKRHVEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDA 1381

  Fly  1379 VARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443
            :.|:|||||:|:||..||.:|||:||::|.||..||||||||..|||||.::|:||||:|...:|
Zfish  1382 IQRTEELEESKKKLAQRLQDAEESIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDK 1446

  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEV 1508
            ||:.|||::.|||.|.::..|||:.:|||.|:.|||:|::|.:|||..:|||.::||||||..|:
Zfish  1447 KQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTEIFKMKNSYEEALDQLETLKRENKNLQQEI 1511

  Fly  1509 KDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR 1573
            .||.:|:||.|::|||:|||:|.:|:||.|:|.||||||..||.||:|:||.||||:||:.||||
Zfish  1512 SDLTEQLGETGKSIHELEKAKKTVESEKVEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDR 1576

  Fly  1574 RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEA 1638
            ::.||:||.|..::|.||.||:||::|::|.:.:.:|||:|||:|.|:||:||.|.|||:..|||
Zfish  1577 KLAEKDEEIEQIKRNSQRVLDAMQSTLDSEVRSRNDALRVKKKMEGDLNEMEIQLSHANRQAAEA 1641

  Fly  1639 QKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ 1703
            ||.::..|.||||.|..|:|..|.::|.:||:.:.|||.|.:|.|:||.|..|||.:|||:.|||
Zfish  1642 QKQLRNVQGQLKDAQLHLDEAVRGQEDMKEQVAMVERRNNLMQAEIEELRAALEQTERGRKVAEQ 1706

  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADEL 1768
            ||.||.|::..:.:||.|:...|:|||::|..:..::|:.:.||:|:|||||||:.|||.:|:||
Zfish  1707 ELVDASERVGLLHSQNTSLINTKKKLEADLVQIQGEVDDAVQEARNAEEKAKKAITDAAMMAEEL 1771

  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            :.|||.:...|:::|.||..:|:||.||||||..|:|||||.:||||.||||||:|::.||||.|
Zfish  1772 KKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGA 1836

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898
            ||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|:::||.
Zfish  1837 DAVKGVRKYERRVKELTYQTEEDKKNVTRLQDLVDKLQLKVKAYKRQAEEAEEQANTHLSRYRKV 1901

  Fly  1899 QQELEEAEERADLAEQAISKFRAKGR 1924
            |.|:|||:||||:||..::|.|||.|
Zfish  1902 QHEMEEAQERADIAESQVNKLRAKSR 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	449/702 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	427/671 (64%)
		Myosin_tail_1	842..1897	CDD:279860	558/1054 (53%)
		V_Alix_like	1557..1877	CDD:187408	174/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
myhz1.1l	XP_017208743.1	Myosin_N	34..72	CDD:308391	9/37 (24%)
		MYSc_class_II	99..768	CDD:276951	427/671 (64%)
		SMC_N	848..1925	CDD:330553	573/1076 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010