DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myhb

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_001339206.5 Gene:myhb / 100002040 ZFINID:ZDB-GENE-081124-1 Length:1937 Species:Danio rerio


Alignment Length:1921 Identity:1072/1921 - (55%)
Similarity:1428/1921 - (74%) Gaps:16/1921 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85
            |:.||: |::|:|:|.:.::.:.||.||.|.:|:.:|...:|....|:...:|.:::..:|||||
Zfish    21 EKERIEAQNRPFDAKTAYFVSEPKEMYLKGVLKSKEGGKATVQTLCGKTLTVKEDEIFPMNPPKF 85

  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            :||||||.||.||.|.||:||::||.|.:||||||||||.:||||..|||.......||||:|.|
Zfish    86 DKIEDMAMMTHLNEPTVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDAVVVSGYRGKKRIE 150

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASKKTDEAAKSK 212
            .|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:   |..|:.....|.:
Zfish   151 APPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVAGKQKQEPIPGKMQ 215

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
            ||||||::..||:|||:|||||||||||||||||||||||.|||||.||||||||||:||..|.|
Zfish   216 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLS 280

  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342
            .|||||||||:.:|..|.:.:..|:|.|.|||.::|||::||.||:|.|||..||.|.|||||..
Zfish   281 AERSYHIFYQLCTGHKPELLEALLITTNPYDYPMISQGEITVKSINDVEEFIATDTAIDILGFNA 345

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407
            :||..:|::|.||||.|.|||||:.||||||.||.|...:::.|.|.::|::.|.|..||:||||
Zfish   346 EEKVGIYKLTGAVMHHGNMKFKQKQREEQAEPDGTEVADKIAYLLGLNSADMLKALCYPRVKVGN 410

  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGF 472
            ||||:|:.|.||.|:..||||.|::::|.|:|.:.||.|||:|.||.|||||||||||||::|..
Zfish   411 EFVTKGQTVPQVNNATMALCKSVYEKMFLWMVVRINEMLDTKQPRQFFIGVLDIAGFEIFDFNSL 475

  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEES 537
            |||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||||.||||||.
Zfish   476 EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEEC 540

  Fly   538 MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLN 602
            |||||||.||..||.:.||||:..||||||.| |:..|||::.||||.|.|||:|||:|||||||
Zfish   541 MFPKATDTTFKNKLHDQHLGKTNCFQKPKPAK-GKAEAHFSLVHYAGTVDYNISGWLDKNKDPLN 604

  Fly   603 DTVVDQFKKSQNKLLIEIFADHA---GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLR 664
            |:||..::||..|||..::|.||   .:|||   .|||: ||||.|.|||:.::|.|..|||.||
Zfish   605 DSVVQLYQKSSVKLLCHLYAAHASTEAESGG---KKGGK-KKGGSFQTVSALFRENLGKLMTNLR 665

  Fly   665 STQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPK 729
            ||.||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...
Zfish   666 STHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNAS 730

  Fly   730 LL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWA 791
            ::   |.:: :|||:|.::..||:...||:.|:|||||:||:||.:||.|||:|..:::..||..
Zfish   731 VIPEGQFID-NKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLVILVTMTQAVC 794

  Fly   792 RGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAK 856
            |||:.||.|.|:..:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::|..:
Zfish   795 RGYVMRKEFVKMMARRESIYSIQYNIRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMAAMKENFE 859

  Fly   857 KAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            |.:|..|..:..:||||.....||.||..|...::.|...|.|.:||...|...|..||.:|::.
Zfish   860 KMKEDLAKALAKKKELEEKMVTLLQEKNDLQLQVASETENLSDAEERCEGLIKSKIQLEAKLKEA 924

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:..|||
Zfish   925 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMTSQDE 989

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            :|.||.||||...|.:|:|.::|||.|||:|.|.|.||||||.:|:||.|||:|||:|.|:|::|
Zfish   990 VIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDLERAK 1054

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||.||::.|||.:|::||:.:::||.|.|...:::||||.:.::.|::||||||||||
Zfish  1055 RKLEGDLKLAQESLMDLENDKQQLEEKLKKKDFETSQFLSRIEDEQSLGIQFQKKIKELQARIEE 1119

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||||.||||:||||||||:.|||||||||||||||:|||||||..||||||||:.
Zfish  1120 LEEEIEAERAARAKVEKQRSDLARELEEISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEEST 1184

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:|...:::|:.:.::.:...|...||
Zfish  1185 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEVDDVSSSMEAVAKSKTNLEK 1249

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.|:..|:|.:||.||..|.:||..|.|.:|..||.::.|||||.||.||||::.|.:.|.|:
Zfish  1250 MCRTLEDQLSEFKSKHDEHVRHINDLSAQKARLQTENGEMGRQLEEKESLVSQLTRSKQAYTQQI 1314

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||.:.:.:|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:
Zfish  1315 EELKRQIEEEVKAKNSLAHAVQSSRHDCDLLREQYEEEQEAKAELQRSMSKANSEVAQWRTKYET 1379

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||||:||..||.:|||:||::|.||..||||||||..|||||.::|:||||:|...
Zfish  1380 DAIQRTEELEEAKKKLAQRLQDAEESIEAVNAKCASLEKTKQRLQNEVEDLMIDVERANALAANL 1444

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:.:|||.|:.|||||::|.:|||..:.||.::||||||..
Zfish  1445 DKKQRNFDKVLAEWKQKYEETQAELEGAQKEARSLSTELFKMKNSYEETLDHLETLKRENKNLQQ 1509

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:|:||.|:.|||:||.:|..|.||.|:|||||||||.||.||:|:||.||||:||:.||
Zfish  1510 EITDLTEQLGETGKTIHELEKGKKTAEIEKSEIQAALEEAEATLEHEESKILRVQLELNQVKGEI 1574

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||::.||:||.|..::|.||.:||||::|:||.:.:.:|||:|||:|.|:||:||.|.|||:..|
Zfish  1575 DRKLAEKDEEIEQIKRNSQRIIDSMQSTLDAEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAA 1639

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.||||.|..|:|..||::|.:||:.:.|||.|.:|.|:||.|..|||.:|||:.|
Zfish  1640 EAQKQLRNVQGQLKDAQLHLDEALRAQEDMKEQVAMVERRNNLMQAEIEELRVALEQTERGRKVA 1704

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|::..:.:||.|:...|:|||::|..:..::::::.||:|:|||||||:.|||.:|:
Zfish  1705 EQELVDASERVTLLHSQNTSLINTKKKLEADLVQIQGEMEDVVQEARNAEEKAKKAITDAAMMAE 1769

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.||..:|:||.||||||:.|:|||||.:||||.||||||:|::.||||
Zfish  1770 ELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAESLAMKGGKKQLQKLEARVRELESEVEAEQRR 1834

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|:|||.|..:|.:||
Zfish  1835 GADAVKGVRKYERRVKELTYQTEEDKKNIIRLQDLVDKLQLKVKAYKRQSEDAEEQANTHLTRFR 1899

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGA 1932
            |.|.|||||:||||:||..::|.|||.|....|:.|
Zfish  1900 KVQHELEEAQERADIAESQVNKLRAKSREFGKGKEA 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/36 (25%)
MYSc 81..777 CDD:214580 446/704 (63%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 424/673 (63%)
Myosin_tail_1 842..1897 CDD:279860 561/1054 (53%)
V_Alix_like 1557..1877 CDD:187408 175/319 (55%)
ATP-synt_B <1671..1771 CDD:304375 47/99 (47%)
TMPIT 1739..>1825 CDD:285135 48/85 (56%)
myhbXP_001339206.5 Myosin_N 36..73 CDD:280832 9/36 (25%)
Myosin_head 88..768 CDD:278492 433/685 (63%)
MYSc_class_II 100..768 CDD:276951 424/673 (63%)
Myosin_tail_1 848..1925 CDD:279860 577/1076 (54%)
Uso1_p115_C 898..1011 CDD:282695 47/112 (42%)
COG6 1374..>1509 CDD:303003 78/134 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1098 1.000 Domainoid score I20
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2094 1.000 Inparanoid score I40
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm24867
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2660
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1212.000

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