DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and smyhc3

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001129995.1 Gene:smyhc3 / 100001337 ZFINID:ZDB-GENE-080930-1 Length:1938 Species:Danio rerio


Alignment Length:1917 Identity:1065/1917 - (55%)
Similarity:1421/1917 - (74%) Gaps:10/1917 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |||..|..:|...|::|:|.||.|::||..|.||...:.:..||..:.....|....:|...|..
Zfish    14 PYLRKSDRERLEAQTRPFDMKKECFVPDADEEYLKATVISRDGDKATCETSKGTTVTVKECDVHP 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||..|.|:.|.||.||::||.|.:||||||||||.:||||..|||.......||
Zfish    79 QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAA 209
            ||:|:|.|||||:|||.||..||::..|||:|||||||||||.|||:||.|||::.||....|..
Zfish   144 GKKRSEAPPHIFSISDNAYQYMLSDRENQSILITGESGAGKTVNTKRVIQYFASIAASPTKKETT 208

  Fly   210 KSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVIS 274
            :.||:||||::|.||.|||||||||:||||||||||||||||..:||||.||||||||||:||..
Zfish   209 EKKGTLEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFAASGKLASADIETYLLEKSRVTF 273

  Fly   275 QQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILG 339
            |...||.|||||||:|...|.:.::.|:|.|.|||..:|||:..||||:||:|...||:|||:||
Zfish   274 QLKAERDYHIFYQILSQKKPELLEMLLITANPYDYAFISQGETQVASINDADELMATDEAFDVLG 338

  Fly   340 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIK 404
            ||::||..:|::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..||:|
Zfish   339 FTQEEKNSIYKLTGAIMHYGNMKFKQKQREEQAEADGTEDADKSAYLMGLNSADLIKALCHPRVK 403

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEY 469
            ||||:||:|:|||||..:||||.|.|::::|.|:|.:.|::|||:|.||:|||||||||||||::
Zfish   404 VGNEWVTKGQNVQQVYYAIGALSKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFDF 468

  Fly   470 NGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILE 534
            |.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:||||
Zfish   469 NTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILE 533

  Fly   535 EESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKD 599
            ||.|||||:|.||..||.:.|||||..||||:..| |:..|||::.||||.|.|||..||.||||
Zfish   534 EECMFPKASDATFKAKLYDNHLGKSNNFQKPRIVK-GKPEAHFSLVHYAGTVDYNINNWLVKNKD 597

  Fly   600 PLNDTVVDQFKKSQNKLLIEIFADHAG----QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLM 660
            |||:|||..::||..|:|..:||::||    ..|||.:.| .:.|||..|.|||:.::|.||.||
Zfish   598 PLNETVVGLYQKSTMKMLSILFANYAGAESAAEGGGGKTK-EKKKKGSSFQTVSALHRENLNKLM 661

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            |.||||.|||||||||||.|.||.::..||||||.||||||||||||||||||::|.|||.||:|
Zfish   662 TNLRSTHPHFVRCIIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRI 726

  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787
            :.|..:   |.:: .:|..|.::..:|:..:||:.|:|||||:||:||.:||.||:||..|::.:
Zfish   727 LNPAAIPDGQFID-SRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGTLEEMRDDRLALIITNI 790

  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852
            ||.|||.|||..|:|:.::|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
Zfish   791 QARARGLLSRVEFQKIVDRRDALLVIQWNVRAFMGVKNWPWMKLYFKIKPLLRSAEAEKEMANMK 855

  Fly   853 EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQ 917
            |:..|.:|.:|.....|||||.....||.||..|..::..|:..|.|.:||...|...|..||.:
Zfish   856 EEFLKLKEAYAKSEARRKELEEKMVSLLQEKNDLQLAVQTEQDNLCDAEERCEGLIKNKIQLEAK 920

  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982
            .:::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|
Zfish   921 AKELTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985

  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDV 1047
            ..||:|.||.||||...|.:|:|.::||:.|||:|.|.|.||||||.:|:||.|||:|||:|.|:
Zfish   986 ALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDL 1050

  Fly  1048 EKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQA 1112
            |::|||:|||||||||:|.|||.:|::||:.:::||.|:|.:::::||||.:..:.|:::|||||
Zfish  1051 ERAKRKLEGDLKLTQESVMDLENDKQQLEERLKKKDFEISQLSSRIEDEQAMAAQLQKKLKELQA 1115

  Fly  1113 RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDL 1177
            ||||||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||
Zfish  1116 RIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDL 1180

  Fly  1178 EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKA 1242
            |||.:|||:|.:.|||||.|:|:::.||:|.|.::|.|.||||:|...:|:|:.:.::.|...||
Zfish  1181 EEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIAKAKA 1245

  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307
            ..||:.:.|:..::|.::|.:|..|::|||...|.||..||.:|.|||||.:|.||||::.|.|.
Zfish  1246 NLEKMCRTLEDQMSEYRTKYEEGQRSINDFTMKKAKLQTENGELSRQLEEKDSLVSQLTRGKQSY 1310

  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372
            |.|:||.||..:||.:.:..|....::..||.:.||||.|||.|.||:|||.|||||:|...||:
Zfish  1311 TQQIEDLKRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRT 1375

  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAI 1437
            |||:|.:.|:||||:||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:||.
Zfish  1376 KYETDAIQRTEELEDAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440

  Fly  1438 ANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENK 1502
            |.|.:|||:.|||::.|||.|.::..:||::||||.|:.|||||:||.:|||..:.||:::||||
Zfish  1441 AAALDKKQRNFDKVLAEWKQKYEESQSELESSQKEARSLSTELFKLKNSYEESLDHLESMKRENK 1505

  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567
            ||.:|:.||.:||||.|:||||:||.||:||.||.|:|.||||||.:||.||.|:||||||.:||
Zfish  1506 NLQEEIADLTEQIGESGKNIHELEKMRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQV 1570

  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632
            :.:|:|::.||:||.|..::|.||.:|::|:|||:|.:.:.||||:|||:|.|:||:||.|..||
Zfish  1571 KADIERKLSEKDEEMEQAKRNQQRMIDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQAN 1635

  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697
            :..:||||.:|.....|||.|..|::..|..||.:|.:.|.|||.|.||.||:|.|:|:||.:||
Zfish  1636 RQASEAQKQLKSLHGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERG 1700

  Fly  1698 RRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAA 1762
            |:.|||||.|..|::..:.:||.|:...|:|||.:...|.::::|.:.|.:|:|||||||:.|||
Zfish  1701 RKLAEQELMDVSERVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITDAA 1765

  Fly  1763 RLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDG 1827
            .:|:||:.|||.:...|:::|.:||.||:||.||||||..|:|||||.:||||.||||||:|::.
Zfish  1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLEARVRELESEVEM 1830

  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNL 1892
            |||:.:|:.|.:||.|||:|||::|:||||||..|:||||||||.|:|:|||..|||||.|..||
Zfish  1831 EQRKASDSVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANSNL 1895

  Fly  1893 AKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            .||||.|.||:|||||||:||..::|.|||.|
Zfish  1896 GKFRKLQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/36 (28%)
MYSc 81..777 CDD:214580 438/702 (62%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 418/671 (62%)
Myosin_tail_1 842..1897 CDD:279860 555/1054 (53%)
V_Alix_like 1557..1877 CDD:187408 167/319 (52%)
ATP-synt_B <1671..1771 CDD:304375 48/99 (48%)
TMPIT 1739..>1825 CDD:285135 49/85 (58%)
smyhc3NP_001129995.1 Myosin_N 35..72 CDD:280832 10/36 (28%)
Myosin_head 87..768 CDD:278492 425/683 (62%)
MYSc_class_II 99..768 CDD:276951 418/671 (62%)
Myosin_tail_1 848..1925 CDD:279860 571/1076 (53%)
RILP-like 963..1096 CDD:304877 68/132 (52%)
mycoplas_twoTM 1183..>1320 CDD:275320 61/136 (45%)
TMPIT 1742..>1827 CDD:285135 49/84 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H68044
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2660
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.030

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