Protein Alignment ppk17 and ASIC3

DIOPT Version :10

• Sequence 1: NP_609809.1
• Gene: ppk17 / 35006
• FlyBaseID: FBgn0032602
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 91/499 - (18%)
• Similarity: 156/499 - (31%)
• Gaps: 161/499 - (32%)

  Fly     2 GYWSETRAWLFRDPAKLIRYLVLFACCIVVIVQLYECFAKLYNPPISTHSYYSLNE----TIEMP 62
            |.|:          |.::..:..|...:...|:.|..|          |...:|:|    .:..|
Human    43 GMWA----------AAVVLSVATFLYQVAERVRYYREF----------HHQTALDERESHRLIFP 87

  Fly    63 SVTICREPPYKEEVLT-----------------------RLSG------GACPHPKYATCWMKYP 98
            :||:|...|.:...||                       |..|      |..|.|.:
Human    88 AVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTF-------- 144

  Fly    99 FGEISLDEFFENSTHDSGDTFV---FYGLNEDKNNVVMNSSLHFYMGRCYTLRPKE------SAK 154
                .:.:.:..:.|...|..:   |.|......|.   :::...||:|||.....      :..
Human   145 ----DMAQLYARAGHSLDDMLLDCRFRGQPCGPENF---TTIFTRMGKCYTFNSGADGAELLTTT 202

  Fly   155 RVSKAVGYSIML---EHSMLTTSVSDVDTG-SVGWHVFIHDKKENFTEINMKGSGRVEYVFVGVN 215
            |.....|..|||   :...|.....:.:|. .||..|.||.::|. ..|:..|.|      |...
Human   203 RGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEP-PIIDQLGLG------VSPG 260

  Fly   216 EEIEIKLQTQYFSNVQTREEACSD-----------------------------------DENYSD 245
            .:..:..|.|..|.:......||.                                   :..|..
Human   261 YQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVA 325

  Fly   246 LKCGEQCIWQDLADNMQCSGPWMHEIASEPCNDSLSMRKLISDYKDVYENEDDFDCDCVQPCQSR 310
            .|||.:.::.. .|...|| |..::..:.|..|:: :||              ..|.|..||.|.
Human   326 RKCGCRMVYMP-GDVPVCS-PQQYKNCAHPAIDAM-LRK--------------DSCACPNPCAST 373

  Fly   311 IYTTFIQ-----------------NRKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIADV 358
            .|...:.                 ||......|....:.|::.......:|::.:|:.::.:.|:
Human   374 RYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDI 438

  Fly   359 GGSLGFLLGLSVLGLIGILEHMMLFF----CGGFIKRMQQKEQA 398
            ||.:|..:|.|:|.::.||:::...|    .|.|..|...:..:
Human   439 GGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHS 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_609809.1	ASC	22..358	CDD:459966	75/433 (17%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	91/499 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		0/21 (0%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)