DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk17 and SCNN1D

DIOPT Version :9

Sequence 1:	NP_001285988.1	Gene:	ppk17 / 35006	FlyBaseID:	FBgn0032602	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001123885.2	Gene:	SCNN1D / 6339	HGNCID:	10601	Length:	802	Species:	Homo sapiens

Alignment Length:	495	Identity:	102/495 - (20%)
Similarity:	178/495 - (35%)	Gaps:	139/495 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RDPAKLIRYLVLFACCIVVIVQLYECFAK-----LYNPPISTHSYYSLNETIEMPSVTICR-EPP 71
            |.|:.::|:|           :|.:.||:     |||        .:|::.....|.|:.| |||
Human   303 RRPSPVLRHL-----------ELLDEFARENIDSLYN--------VNLSKGRAALSATVPRHEPP 348

  Fly    72 Y---KEEVLTRLS----------------GGACPHPKYAT------CWMKYPFGEI--SLDEFFE 109
            :   :|..|.|||                ||.|.:..|.:      .|..:.:.:|  .|...:|
Human   349 FHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWE 413

  Fly   110 NSTHDSGDTFVFYGLNEDKNNVVMNSSLHFY---MGRCYTLRPKESAKR--VSKAVGYSIMLE-- 167
            :| |.|.|.......:.|..:........|:   .|.|||:....:|:|  ::..||..:.:|
Human   414 DS-HGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQ 477

  Fly   168 -HSMLTTSVSDV--------DTGSVGWHVF---------IHDKKENFTEINMKGSGRVEYVFVGV 214
             |..|.::::.:        .|..:|.|.|         |..:::   |::..||........|.
Human   478 PHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIRED---EVHRLGSPYGHCTAGGE 539

  Fly   215 NEEIEIKLQTQYFSNVQTREEACSDDENYSDLKCGEQCIWQDLADNMQCSGPWMHEI--ASEPCN 277
            ..|:|:...|.|     ||:            .|...|..|.:.:...| |.::|.:  .:|.|:
Human   540 GVEVELLHNTSY-----TRQ------------ACLVSCFQQLMVETCSC-GYYLHPLPAGAEYCS 586

  Fly   278 DSL------SMRKLISDYKDVYENEDDFDCDCVQPCQSRIY--------------------TTFI 316
            .:.      ...:|   |:|:..:.......|.:||:...:                    |...
Human   587 SARHPAWGHCFYRL---YQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGE 648

  Fly   317 QN--RKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIADVGGSLGFLLGLSVLGLIGILEH 379
            |.  .::..|.....:|.|.|.......:||.|.|...|.::.:|.......|.|||.|:.:||.
Human   649 QGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLEL 713

  Fly   380 M-----MLFFCGGFIKRMQQKEQAKLEANSEDGQSQTSDE 414
            :     :....||  :|:::...:...|:...|.|....|
Human   714 LLDASALTLVLGG--RRLRRAWFSWPRASPASGASSIKPE 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	87/432 (20%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	102/495 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..777		4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830