DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk17 and SCNN1B

DIOPT Version :9

Sequence 1:	NP_001285988.1	Gene:	ppk17 / 35006	FlyBaseID:	FBgn0032602	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	XP_016879014.1	Gene:	SCNN1B / 6338	HGNCID:	10600	Length:	659	Species:	Homo sapiens

Alignment Length:	603	Identity:	105/603 - (17%)
Similarity:	177/603 - (29%)	Gaps:	225/603 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GY-WSETRAW-------------LFRDPAKLIRYLVLFACCIVVIVQLYECFAKLYNPPISTHSY 52
            || :.|...|             :...|.|...:.:|......::...:..|.:.|   :|....
Human    38 GYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTY---LSWEVS 99

  Fly    53 YSLN---ETIEMPSVTICREPPYK---------------EEVLTRLSGGACPHPKYA-----TCW 94
            .||:   :|::.|:||||...|:|               |.||.|:......|....     :.|
Human   100 VSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIW 164

  Fly    95 ---------MKYPFGEISLDEF----------------------------------------FEN 110
                     .:.|...:.||.|                                        |.:
Human   165 NHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTS 229

  Fly   111 STHDSGDTFVFYGLN----------------------------EDKNNVVMNSSLHFYMGRCYTL 147
            :|....:.::....|                            |..|.....|..:.:.|.||..
Human   230 ATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIF 294

  Fly   148 RPKESAKRVSKA-----VGYSIMLEHSMLTTSVSDVD-----TGSVGWHVFIHDKKENFTEINMK 202
            ....:.|.:..|     .|..::|:       :...|     ..:.|..:.:|::: ::..|..:
Human   295 NWGMTEKALPSANPGTEFGLKLILD-------IGQEDYVPFLASTAGVRLMLHEQR-SYPFIRDE 351

  Fly   203 GSGRVEYVFVGVNEEI----------------------EIKLQTQYFS-----NVQTREEACSDD 240
            |.    |...|....|                      |:.:|..|..     ::|....:|..|
Human   352 GI----YAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQD 412

  Fly   241 ENYSDLKCG----------EQCIWQDLADNMQCSGPWMHEIA---------SEPCND-----SLS 281
            ....:..||          :.|..:|..|...|.......:|         .|.|||     ::|
Human   413 HMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTIS 477

  Fly   282 MRKLISDYKD-----VYENEDDFDCDCVQPCQSRIYTTFIQNRKAFNQPEPRTQIYIYYTTKLIS 341
            |....|:..:     |...|.|         ||   |....:||..      .::.||:......
Human   478 MADWPSEASEDWIFHVLSQERD---------QS---TNITLSRKGI------VKLNIYFQEFNYR 524

  Fly   342 MIEERPSYDTTQFIADVGGSLGFLLGLSVLGLIGILEHMMLFFCGGFIKRM-------QQKEQAK 399
            .|||..:.:....::::||..||.:|.|||.||...|.::.|.....||.:       |::.||
Human   525 TIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQA- 588

  Fly   400 LEANSEDGQSQTSDETID 417
                |..|...|..|.::
Human   589 ----SYAGPPPTVAELVE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	80/512 (16%)
SCNN1B	XP_016879014.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830