Protein Alignment ppk17 and ASIC5

DIOPT Version :9

• Sequence 1: NP_001285988.1
• Gene: ppk17 / 35006
• FlyBaseID: FBgn0032602
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 91/484 - (18%)
• Similarity: 167/484 - (34%)
• Gaps: 146/484 - (30%)

  Fly    11 LFRDPAKLIRYL---VLFACCIVVIVQLYECFAKLYNPPISTHSYYSLNETIEMPSVTICREPPY 72
            :.::.:|:.|.|   |:.....:|..|:|......:..|.:|.......|.:|.|:||.|....:
Human    53 IVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRF 117

  Fly    73 KEEVLTRLSGGACPHPKYATCWMKYPFGEI-----------SLDEFFENSTHD--------SGDT 118
            :.:.:.:                   ||.|           .|.|...|||..        |...
Human   118 QTDAVAK-------------------FGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQN 163

  Fly   119 FVFYGLNEDKNNVVMNSSL----------------HFY--MGRCYTLRPKES--AKRVSKAVGYS 163
            |.......:|...:.||:|                |.:  .|.|:|....|:  |||.....|..
Human   164 FSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRG 228

  Fly   164 IMLEHSMLTTSVSD------VDTGSVGWHVFIHDKKE--NFTEINMKGSGRVEYVFVGVNEEIEI 220
            :.|..::...:.:|      ||.|.:   ..||..|:  .|..:.:...       ||::..:.|
Human   229 LSLLFNVNQEAFTDNPALGFVDAGII---FVIHSPKKVPQFDGLGLLSP-------VGMHARVTI 283

  Fly   221 K-----------------LQTQYFSNVQTREEACSDDENYSDLKCGEQC-----------IWQDL 257
            :                 ::.|.||:..|  ..|..:.....:|  :||           |..||
Human   284 RQVKTVHQEYPWGECNPNIKLQNFSSYST--SGCLKECKAQHIK--KQCGCVPFLLPGYGIECDL 344

  Fly   258 ADNMQCSGPWMHEIASEPCNDSLSMRKLISDYKDV-----YENEDDFDCDCVQPCQSRIYTTFIQ 317
            .....|..|.:..|                ::||:     :.:.....|:.::...:..|::|..
Human   345 QKYFSCVSPVLDHI----------------EFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPS 393

  Fly   318 NR------KAFNQP-----EPRTQIYIYYTTKLISMIEERPSYDTTQFIADVGGSLGFLLGLSVL 371
            .:      |..||.     |...:|.|.|:.....:.:::.:...::.:||:||.||...|.|::
Human   394 QKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLI 458

  Fly   372 GLIGILEHMMLFF---CGGFIKRMQQKEQ 397
            .:|.|:|::...|   |..|:.::.:..|
Human   459 TIIEIIEYLFTNFYWICIFFLLKISEMTQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	77/440 (18%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	86/461 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910