Protein Alignment ppk17 and ASIC2

DIOPT Version :9

• Sequence 1: NP_001285988.1
• Gene: ppk17 / 35006
• FlyBaseID: FBgn0032602
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 86/482 - (17%)
• Similarity: 155/482 - (32%)
• Gaps: 152/482 - (31%)

  Fly    46 PISTHSYYSLNETIEMPSVTICREPPYKEEVLTRLSGGACPHPKYATCWM--------------- 95
            |..|..:...:..:..|:||:|...|.:   ..|||.|..   .||..|:
Human   115 PSHTRVHREWSRQLPFPAVTVCNNNPLR---FPRLSKGDL---YYAGHWLGLLLPNRTARPLVSE 173

  Fly    96 --------KYPFGEISLDEFFENSTHDSGDTFVFYG-LNEDKNNVVMN-------------SSLH 138
                    :..|.:::....|....|..|.:..|.. |.....:::::             ||:.
Human   174 LLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF 238

  Fly   139 FYMGRCYTLRPKESAKRVSKAV------GYSIML----EHSMLTTSVSDVDTGSVGWHVFIHDKK 193
            ...|:||.....|..|.:...|      |..|||    :..:.....::..|...|..|.||.:.
Human   239 TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 303

  Fly   194 ENFTEINMKGSGRVEYVFVGVNEEIEIKLQTQYFSNVQTREE----------ACSDDEN------ 242
            |.              .|:   :|:...:...:.:.|.|:|:          .|...|.
Human   304 EP--------------PFI---QELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP 351

  Fly   243 -YSDLKCGEQCIWQDLADNMQC-----------SGPWMHEIASEPCNDSLSMRKLISDYKDVYEN 295
             ||...|...|..:.:.:|..|           ..|..|:..:||....|:            |.
Human   352 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLA------------EK 404

  Fly   296 EDDFDCDCVQPCQSRIY------------TTFIQNRKAFNQPEPRTQ-----IYIYYTTKLISMI 343
            :.:: |.|..||....|            |:.....|.||:.|....     :.|::.......|
Human   405 DSNY-CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI 468

  Fly   344 EERPSYDTTQFIADVGGSLGFLLGLSVLGLIGILEHMMLFFCGGFIKRMQQKEQAKLEANSED-- 406
            |::.:|:....:.|:||.:|..:|.|:|.::.:.:         :|..:.:::...|....||
Human   469 EQKKAYEVAALLGDIGGQMGLFIGASILTILELFD---------YIYELIKEKLLDLLGKEEDEG 524

  Fly   407 -------------GQSQTSDETIDVEI 420
                         ..|:|...|::|.:
Human   525 SHDENVSTCDTMPNHSETISHTVNVPL 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	71/403 (18%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	84/476 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740