DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk17 and egas-4

DIOPT Version :9

Sequence 1:	NP_001285988.1	Gene:	ppk17 / 35006	FlyBaseID:	FBgn0032602	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_501207.2	Gene:	egas-4 / 3564809	WormBaseID:	WBGene00018906	Length:	883	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	94/443 - (21%)
Similarity:	166/443 - (37%)	Gaps:	124/443 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ECFAKLYNPPIS-----THSYYSLNETIE----MPSVTICR-EPPYKEEVLT----------RLS 81
            || ..:..||.|     |..:...|.||:    :...|:|: :.|....|.|          .:.
Worm   455 EC-EDIIGPPNSYNCTCTPQWTGFNCTIDVDECVEDTTLCKTKDPDATCVNTNGSYYCVCSPNMF 518

  Fly    82 GGACPHPKYATCWMKYPFGEI---SLDEFFENSTHD--------------------------SGD 117
            |.:|...|.....:...:|::   .|||..:..|:|                          :.|
Worm   519 GKSCLFNKIIYQILNATYGDLGPDKLDEMAQELTNDPTLVRDIVPFLIGGYSLEVRTSLSWTAAD 583

  Fly   118 TFVFYGLNE-----DKNNVVMNSSLHFYMGRCYTLRPKESA-KRVSKAVGYSIMLEHSMLTTSVS 176
            .|::....:     :.|.|..|..:   :|.|:|.....|: |..:::.||...||..|   :|.
Worm   584 MFLWVAYEQQLIDLNSNFVQWNDKV---LGNCFTFNHMNSSFKYEARSSGYPGGLEMQM---NVK 642

  Fly   177 DVD----TGSVGWHVFIHDKKENFTEINMK-----------GSGRVEYVFVG------VNEEIEI 220
            ..:    |.:.|..||...|:|..|..:::           ...||:|..:|      :|...|:
Worm   643 QDEYLPWTETAGVMVFTSTKEEAVTSESVRINTAPHFESRIAINRVDYYRLGGRYGVCINSVSEV 707

  Fly   221 KLQTQYFSNVQTREEACSDDENYSDLKCGEQCIWQDLAD-NMQCSGPWMHEIASEPCNDSLSMRK 284
            |  :.|:            |.:|:...|...| :||:.: :..|..| .:.:.::..:.|:|.:.
Worm   708 K--SYYY------------DGDYTTDGCLRSC-YQDVVNGDCGCMDP-RYPMPNDGISCSISQKT 756

  Fly   285 LISDYKDVYENEDDF-DCDCVQPCQSRIYTTFIQN----RKAFNQPEPRTQIYIYYTTKLISMI- 343
            .|.:..|...:...: :|.|..||...:||:.:..    .|..:..|..|.....|.|.|.|:|
Worm   757 CIDELVDSRGDPSTWPECTCPLPCSQTVYTSKLSRLPYVNKIVDCEEAYTNKTACYETFLDSVIL 821

  Fly   344 ------------EERPSYDTTQFIADVGGSLGFLLGLSVLGLIGILEHMMLFF 384
                        .|.|:.|.|:|::.:||.|..|:|:|::..:      .|||
Worm   822 RISLPKLDYMIYSETPAMDLTKFMSYLGGILSILIGVSIVSFV------ELFF 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	85/415 (20%)
egas-4	NP_501207.2	EGF	101..131	CDD:278437
		EGF_CA	482..522	CDD:238011	6/39 (15%)
		ASC	<610..869	CDD:279230	66/284 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910