DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk17 and Scnn1b

DIOPT Version :10

Sequence 1:NP_609809.1 Gene:ppk17 / 35006 FlyBaseID:FBgn0032602 Length:431 Species:Drosophila melanogaster
Sequence 2:NP_035455.1 Gene:Scnn1b / 20277 MGIID:104696 Length:638 Species:Mus musculus


Alignment Length:548 Identity:99/548 - (18%)
Similarity:171/548 - (31%) Gaps:214/548 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VLFACCIV----VIVQLYECFAKLYNPPISTHSYYSLN---ETIEMPSVTICREPPYK------- 73
            :||||.:.    |.:|.|          :|.....||:   :|:..|:||:|...|::       
Mouse    57 LLFACLVCWQWGVFIQTY----------LSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHL 111

  Fly    74 --------EEVLTRLSGGACPHPKYA-----TCWMKYPFGEISLDE----------FFENSTHDS 115
                    |.||.::......|....     |.|...|.  :.:||          .|.:| |:|
Mouse   112 LKDLDELMEAVLEKILAPEASHSNTTRTLNFTIWNHTPL--VLIDERNPDHPVVLNLFGDS-HNS 173

  Fly   116 GD----------------------------------------------TFVF--------YGLNE 126
            .:                                              |.:|        .|:..
Mouse   174 SNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGY 238

  Fly   127 DKNNVVM------------NSSLHFY--MGRCYTLR---PKESAKRVSKAVGYSIMLEHSMLTTS 174
            ..:.:::            |.:..||  .|.||...   .:|:....:....:.:.|        
Mouse   239 APDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKL-------- 295

  Fly   175 VSDVD--------TGSVGWHVFIHDKKENFTEINMKGSGRVEYVFVGVNEEIEI---KLQ----- 223
            :.|:.        ..:.|..:.:|::: .:..|..:|.    |...|....|.:   |||     
Mouse   296 ILDIGQEDYVPFLASTAGARLMLHEQR-TYPFIREEGI----YAMAGTETSIGVLVDKLQRKGEP 355

  Fly   224 ---------------------TQYFSNVQTREEACSDDENYSDLKCG----------EQCIWQDL 257
                                 |.|  ::|....:|..|....:..||          :.|..:|.
Mouse   356 YSPCTMNGSDVAIKNLYSVYNTTY--SIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDF 418

  Fly   258 AD------NMQCSGPWMH---EIASEPCNDS-LSMRKLISDYKDVYENEDDFDCDCVQPCQSRIY 312
            .|      |:|.|.....   .:..|.|||: ..|...::|:..  |..:|:....:.  |.|..
Mouse   419 PDWAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPS--EASEDWILHVLS--QERDQ 479

  Fly   313 TTFIQ-NRKAFNQPEPRTQIYIYYTTKLISMIEERPSYDTTQFIADVGGSLGFLLGLSVLGLIGI 376
            ::.|. :||..      .::.||:.......|||.|:.:....::::||..||.:|.|||.||..
Mouse   480 SSNITLSRKGI------VKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEF 538

  Fly   377 LEHMMLFF----------CGGFIKRMQQ 394
            .|.::.|.          |.|..:|..|
Mouse   539 GEIIIDFIWITIIKLVASCKGLRRRRPQ 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk17NP_609809.1 ASC 22..358 CDD:459966 83/500 (17%)
Scnn1bNP_035455.1 ENaC 21..621 CDD:273304 99/548 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168 614..618
Blue background indicates that the domain is not in the aligned region.

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