DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ppk17 and Scnn1a

DIOPT Version :10

Sequence 1:NP_609809.1 Gene:ppk17 / 35006 FlyBaseID:FBgn0032602 Length:431 Species:Drosophila melanogaster
Sequence 2:NP_035454.3 Gene:Scnn1a / 20276 MGIID:101782 Length:699 Species:Mus musculus


Alignment Length:516 Identity:89/516 - (17%)
Similarity:155/516 - (30%) Gaps:187/516 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 YLVLFACCI-VVIVQLYECFAKLYNPPISTHSYYSLN-ETIEMPSVTICREPPYK---------- 73
            :.||:.|.. ::..|....|.:.::.|:|.:  .:|| :.:..|:||:|...||:          
Mouse   112 WAVLWLCTFGMMYWQFALLFEEYFSYPVSLN--INLNSDKLVFPAVTVCTLNPYRYTEIKEDLEE 174

  Fly    74 -----EEVL----------TRLSG----------GACPHP------------------------- 88
                 |:.|          ||.:|          ||.|||                         
Mouse   175 LDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRD 239

  Fly    89 ------------KYATC--------WMKYPFGEISLDEFFE----NSTHDSGDT----------- 118
                        .:..|        :..|..|..::.|::.    |......||           
Mouse   240 NNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGS 304

  Fly   119 FVF-YGLNEDKNNVVMNSSLHFYM-GRCYTLRPK-------ESAKRVSKAVGYSIMLEHSMLTTS 174
            |:| ...|:...|....|..|..| |.|||...|       .|...|:..:..::..|.:.....
Mouse   305 FIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPL 369

  Fly   175 VSDVDTGSVGWHVFIHDKKENFTEINMKGSGRVEYVFV---GVNEEIEIKLQTQYFSNVQTREEA 236
            :|.|    .|..|.:|              |:.|..|:   |.|....::      :::..|:||
Mouse   370 LSTV----TGARVMVH--------------GQDEPAFMDDGGFNVRPGVE------TSISMRKEA 410

  Fly   237 ----------CSDD-----------ENYSDLKCGEQCIWQDLADNMQCSGPWMHEIASEPCNDSL 280
                      |:::           ..|:...|...|..:::.....|:..:..:.......|.|
Mouse   411 LDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYL 475

  Fly   281 SMRKLISDYKDVYENEDDFDCD-------CVQPC-------------------QSRIYTTF-IQN 318
            ........|   |:.:..|..|       |.:||                   |..|:... :||
Mouse   476 KQSSWGYCY---YKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQN 537

  Fly   319 RKAFNQPEPR-TQIYIYYTTKLISMIEERPSYDTTQFIADVGGSLGFLLGLSVLGLIGILE 378
            ....|..... .::.|::.........|.||......::::|.......|.|||.::.:.|
Mouse   538 NYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAE 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk17NP_609809.1 ASC 22..358 CDD:459966 83/493 (17%)
Scnn1aNP_035454.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
ENaC 79..676 CDD:273304 89/516 (17%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438 200..270 7/69 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 3/32 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..699
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088 669..673
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.