DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC3

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_005436.1	Gene:	SMC3 / 9126	HGNCID:	2468	Length:	1217	Species:	Homo sapiens

Alignment Length:	1330	Identity:	310/1330 - (23%)
Similarity:	567/1330 - (42%)	Gaps:	253/1330 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLI 151
            :.|.:::.:.|:||..:..:.||......|:|.|||||||...::.||.....:.:|.::...|:
Human     1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALL 65

  Fly   152 HSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVP-DSSIVIERTAMSDNSSYYQINDKRAQLKDVA 215
            |..:. |.:.|..|.:.|       |.:...:| |...|..|..:......|.::.|.....||.
Human    66 HEGTG-PRVISAFVEIIF-------DNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVM 122

  Fly   216 KLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVD 280
            .||:.......:..:::.||::..:|       |..::..|:.|.::.||:.|       ::|.:
Human   123 NLLESAGFSRSNPYYIVKQGKINQMA-------TAPDSQRLKLLREVAGTRVY-------DERKE 173

  Fly   281 QL------TDDRTEKHNR-CKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHI-QKIISIKKS 337
            :.      |:.:.||.|. .|..|..:..||:...|...| :|.:::.|...:.| .:.::..::
Human   174 ESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-QKWDKMRRALEYTIYNQELNETRA 237

  Fly   338 KLEQYTQEHEACAEELK--------THDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKR 394
            ||::.:.:.|...|:.:        ..|:.....:|.|..|..|...:.|:.:...:::||||:|
Human   238 KLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQR 302

  Fly   395 LVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKV 459
             ..:|....::|..:...::|||:   .:::.:|.||.:    |:.|:|:.:...|..|::
Human   303 -TKLELKAKDLQDELAGNSEQRKR---LLKERQKLLEKI----EEKQKELAETEPKFNSVK---- 355

  Fly   460 TLNEELEKQQAELTKTTAPLT---------------EKRLK-LSDELVGLKEKVNTAKGEVQVFE 508
               |:.|:..|.|.:.|...|               |:|.| :..||..|.:.:|..|.::..
Human   356 ---EKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAA-- 415

  Fly   509 SQLKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKE 573
                |.|..|.||:.|.:.|: .|.:..:.|.|...||:||......:|.:.....:|.:.:.:|
Human   416 ----IHKDLEDTEANKEKNLE-QYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475

  Fly   574 ERNLSMQCNKLRTEINERSSVMQAQR---------SNNKVLDFLMR----MKMEGKIPGILGRLG 625
            |..........|.::.::..:::|..         |.|||||...|    ..::....||:  :.
Human   476 ENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIV--MN 538

  Fly   626 DLGGIDAKYDIAISTACGRLDNIVTDNYETASAAIGALKEYNV-GRATFITLDKIEHHRREANSR 689
            :.....|.|.....||..||...:.|:.|.::..:....:.|: |..||:.|:|:: .|..|...
Human   539 NFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLD-VRDTAYPE 602

  Fly   690 INTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRV--VTLRGEMIEM 752
            .|  :.:|.:..|  ..:.|...||......||:|..:|..|::|   ..:.:  :||.|:.:..
Human   603 TN--DAIPMISKL--RYNPRFDKAFKHVFGKTLICRSMEVSTQLA---RAFTMDCITLEGDQVSH 660

  Fly   753 TGTMSGG--GSRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLE 815
            .|.::||  .:|..|.::...||              ||.|::    .||:|::|  :..:.::|
Human   661 RGALTGGYYDTRKSRLELQKDVR--------------KAEEEL----GELEAKLN--ENLRRNIE 705

  Fly   816 R---EIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQ-------RQRMLKKTTDERAV 870
            |   ||..|.|.:|:.|.:.::...|..|:..:| ..||:...|       :||.|:..  |.::
Human   706 RINNEIDQLMNQMQQIETQQRKFKASRDSILSEM-KMLKEKRQQSEKTFMPKQRSLQSL--EASL 767

  Fly   871 KEREEQIEAAKQE-----LEQAQFAEQ----AVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQ 926
            ...|...|:.|.|     |.|....:|    |::.:|.::|.:...|.||.:| :|..|.:|.:.
Human   768 HAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIK-LEGIITRVETY 831

  Fly   927 IEKLAANVRSLNVGLATADRNITKITGNNNNLREN-----IKAAEEKLKSLNEDRNKAKEKKEEL 986
            :.:   |:|          :.:.::....|.|||.     :.|...:|:::|:.......:.|:|
Human   832 LNE---NLR----------KRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDL 883

  Fly   987 EKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQA 1051
            :..|:::||.|:       :::|.: |..|...|.:::.|..|||      ::.|:.|.    |.
Human   884 DNSIDKTEAGIK-------ELQKSM-ERWKNMEKEHMDAINHDTK------ELEKMTNR----QG 930

  Fly  1052 QLAPLKLNEIPGETEPQAPLKELNEEELEA-ETLEALQYKQ---------TMLEEDLKTKKPNLS 1106
            .|  ||..|     |....::||.....|| |..:.|..||         |.|::.....|..|.
Human   931 ML--LKKKE-----ECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALD 988

  Fly  1107 CIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRK-------RRYKEFMDGFSIITRKLKEM 1164
            ....|:|::          |.:..::.|:...|:.:.:       |:|:.....|..:::...|:
Human   989 QFVNFSEQK----------EKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEV 1043

  Fly  1165 YQMITLGGDAELEL-----------------------------VDSMDPFT-EGVNFTVRPPKKS 1199
            :|.:..||.|.|.:                             |.|:|.|| .|:..:....:..
Human  1044 FQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGE 1108

  Fly  1200 WKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIV 1264
            .:.:..||||:|:|.:|||:||:....|:|.|..||||.|||.::...|...|.|...:||||..
Human  1109 MREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITT 1173

  Fly  1265 SLRVNMFELANFLVGI---YKVSDCTDSIT 1291
            :.|..:.|.|:...|:   .|||. .|.||
Human  1174 TFRPELLESADKFYGVKFRNKVSH-IDVIT 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	38/159 (24%)
		Smc	89..1281	CDD:224117	304/1316 (23%)
		SMC_hinge	618..733	CDD:214944	29/115 (25%)
		ATP-synt_B	<825..904	CDD:304375	22/94 (23%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	36/96 (38%)
SMC3	NP_005436.1	Smc	1..1194	CDD:224117	304/1319 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..269		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1059..1090		1/30 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810