Protein Alignment glu and SMC5

DIOPT Version :9

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_014608.1
• Gene: SMC5 / 854123
• SGDID: S000005394
• Length: 1093
• Species: Saccharomyces cerevisiae
• Alignment Length: 1283
• Identity: 263/1283 - (20%)
• Similarity: 469/1283 - (36%)
• Gaps: 341/1283 - (26%)

  Fly    80 MESTGPRLIISKIVNRNFKSYA-GEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRI- 142
            :.|..|..|| ||..::|.:|. .|..|.|   |...||||||||||..:.::......:...|
Yeast    34 LSSFQPGSII-KIRLQDFVTYTLTEFNLSP---SLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIG 94

  Fly   143 RCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIER-TAMSDNSSYYQIND 206
            |.|:|...|.:....     ..:.:..|...:..|....|..|.:|.|.| ...|...|.|.|||
Yeast    95 RSKKVEDFIKNGQDV-----SKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLIND 154

  Fly   207 KRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRP 271
            .:.....|..|:.:.::.|::....:.|..||..|.:|                   ..:..:..
Yeast   155 YQVSESVVKTLVAQLNIQLDNLCQFLSQERVEEFARLK-------------------SVKLLVET 200

  Fly   272 LQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKK 336
            ::.|:..:..:.|:.           ||::..||                     .:||.:..||
Yeast   201 IRSIDASLLDVLDEL-----------RELQGNEQ---------------------SLQKDLDFKK 233

  Fly   337 SKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESA 401
            :|:....||.:.                         :||.:|.......|:.:|:  |.:....
Yeast   234 AKIVHLRQESDK-------------------------LRKSVESLRDFQNKKGEIE--LHSQLLP 271

  Fly   402 YTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTLNEELE 466
            |.:::.         .|:|..|.|.|      ::..:.|.|.|....|...:   :|.||..::|
Yeast   272 YVKVKD---------HKEKLNIYKEE------YERAKANLRAILKDKKPFAN---TKKTLENQVE 318

  Fly   467 KQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEV-------QVFESQLKILKQAETTESRK 524
                |||:..:..|::.||..:::..:.||:||.:.||       :.:..:.|  |...|..|.|
Yeast   319 ----ELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTK--KLQATIISTK 377

  Fly   525 YETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEIN 589
            .:.|:|....:|..|.||     .:.|.|...:.||.:|..|:..::.|   :..:.|.:.   :
Yeast   378 EDFLRSQEILAQTHLPEK-----SVFEDIDIKRKEIINKEGEIRDLISE---IDAKANAIN---H 431

  Fly   590 ERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGI-DAKYDIAISTACGRLDNIVTDNY 653
            |..|:.:...|..|.|....::       |||.:..||..: ||.  :.:.......|.|:....
Yeast   432 EMRSIQRQAESKTKSLTTTDKI-------GILNQDQDLKEVRDAV--LMVREHPEMKDKILEPPI 487

  Fly   654 ETASAA-------IGALKEYNVGRATFIT------------LDKIEHHRREANSRINTPENVPRL 699
            .|.||.       :....:||..:|..:.            |||.:.:.||.:|...||
Yeast   488 MTVSAINAQFAAYLAQCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTP------ 546

  Fly   700 YDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEM----IEMTGTMSGGG 760
                .|..:.||...:....:..:..|......:....:.:.:...|.|:    |:...|....|
Yeast   547 ----PVPAETVRDLGFEGYLSDFITGDKRVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNG 607

  Fly   761 ----SRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQ------EQQGSLE 815
                .|.|.|.....::    :||..|:  |....|:.|:      :.|:.|      ||:..:|
Yeast   608 KILFKRIIHGNRLVDIK----QSAYGSK--QVFPTDVSIK------QTNFYQGSIMSNEQKIRIE 660

  Fly   816 REIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAA 880
            .||..|||       ||.....::.:|..|.:.            .:....|.|.|  .:.|...
Yeast   661 NEIINLKN-------EYNDRKSTLDALSNQKSG------------YRHELSELASK--NDDINRE 704

  Fly   881 KQELEQAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIE-----------KLAANV 934
            ..:|.:.:.......|.||.::.:.|.|:.|:.|.|..|||.::.||:           |:|:::
Yeast   705 AHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSM 769

  Fly   935 RSL-NVGLATADRNITKITGNNNNLREN-----IKAAEEKLKSLNEDRNK-AKEKKEELEKEIEE 992
            :|| |.........|.:....|.::..|     ....|..|||..||:.| .||.     ::..|
Yeast   770 KSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFVKEM-----RDTPE 829

  Fly   993 SEASIEGAKSQSSDIKKEIDEIT---KEENKRNIERI-EIDTKLQAAAGKMNKVKNDIPGWQAQL 1053
            .::.:...:|...|.|::::::.   :||...|:..: ::..||::....:|         ..:.
Yeast   830 FQSWMREIRSYDQDTKEKLNKVAEKYEEEGNFNLSFVQDVLDKLESEIAMVN---------HDES 885

  Fly  1054 APLKLNEIPGETEPQAPLKELN----EEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEK 1114
            |...|:::..|      |:||.    ::..:.||::|      .|:||....:|.
Yeast   886 AVTILDQVTAE------LRELEHTVPQQSKDLETIKA------KLKEDHAVLEPK---------- 928

  Fly  1115 RLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELE-- 1177
                      |:||.||                         |:.:...::..:...|...||
Yeast   929 ----------LDDIVSK-------------------------ISARFARLFNNVGSAGAVRLEKP 958

  Fly  1178 ------LVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEI 1236
                  .::.|..|.:..     |.||...:..  ||||:.:|::..:.||..:..:|...:|||
Yeast   959 KDYAEWKIEIMVKFRDNA-----PLKKLDSHTQ--SGGERAVSTVLYMIALQEFTSAPFRVVDEI 1016

  Fly  1237 DAALDFKNVSIVGHYIKERT---KNAQFIIVSLRVNMFELANFLVGIY 1281
            :..:|.:|..||...:.|..   ..:|:.:::.::        |.|::
Yeast  1017 NQGMDSRNERIVHKAMVENACAENTSQYFLITPKL--------LTGLH 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	46/161 (29%)
		Smc	89..1281	CDD:224117	260/1272 (20%)
		SMC_hinge	618..733	CDD:214944	27/134 (20%)
		ATP-synt_B	<825..904	CDD:304375	12/78 (15%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	21/89 (24%)
SMC5	NP_014608.1	Smc	42..1069	CDD:224117	261/1275 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900