Protein Alignment glu and SMC3

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_012461.1
• Gene: SMC3 / 853371
• SGDID: S000003610
• Length: 1230
• Species: Saccharomyces cerevisiae
• Alignment Length: 1409
• Identity: 297/1409 - (21%)
• Similarity: 567/1409 - (40%)
• Gaps: 353/1409 - (25%)

  Fly    87 LIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLI 151
            :.|.:::.:.||:|..|..:..|......|||.|||||||...::.||.....:.::.:....||
Yeast     1 MYIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAAIRFVLSDDYSNLKREERQGLI 65

  Fly   152 HSSSSYPNLRSCSVAVHFKQ----------IVDKGDGTCEDVPDSSIVIERTA--MSDNSSYYQI 204
            |..|. .::.|.||.:.|..          ::.:|        |..:.|.||.  ..|:   ||:
Yeast    66 HQGSG-GSVMSASVEIVFHDPDHSMILPSGVLSRG--------DDEVTIRRTVGLKKDD---YQL 118

  Fly   205 NDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRY- 268
            ||:.....|:.::|:.....:.:...::.||::.::...|.|.:       |:.|||:||.:.:
Yeast   119 NDRNVTKGDIVRMLETAGFSMNNPYNIVPQGKIVALTNAKDKER-------LQLLEDVVGAKSFE 176

  Fly   269 ------IRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFH 327
                  ::.:::..|:..|:..:..|.:::....|:|.|:||           |.|||.|.:..:
Yeast   177 VKLKASLKKMEETEQKKIQINKEMGELNSKLSEMEQERKELE-----------KYNELERNRKIY 230

  Fly   328 --------IQKIISIKKSKL-----------EQYTQEHEACAEELKTHDE-GTAALKQSRAEKET 372
                    :.::|: :..:|           |||.||.:      |..|. ...:.|.|..|...
Yeast   231 QFTLYDRELNEVIN-QMERLDGDYNNTVYSSEQYIQELD------KREDMIDQVSKKLSSIEASL 288

  Fly   373 IIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKD-------KAQIEKNEKEL 430
            .|:...:..:|.:::.| |.::|..|.....::|..:|:..:||..|       |:.||:.:::|
Yeast   289 KIKNATDLQQAKLRESE-ISQKLTNVNVKIKDVQQQIESNEEQRNLDSATLKEIKSIIEQRKQKL 352

  Fly   431 -------------EDLHKLP----EKNQREI------------ED-----CNKKLESLEVSKVTL 461
                         |.::||.    ::.||::            :|     .:.::|.|:.|...|
Yeast   353 SKILPRYQELTKEEAMYKLQLASLQQKQRDLILKKGEYARFKSKDERDTWIHSEIEELKSSIQNL 417

  Fly   462 NE---ELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQ--AETTE 521
            ||   :|:..:..|.|..:.:.|:..:|.|.:.|     ...||:::.|:|:|..|||  :|:.:
Yeast   418 NELESQLQMDRTSLRKQYSAIDEEIEELIDSING-----PDTKGQLEDFDSELIHLKQKLSESLD 477

  Fly   522 SRK------------YETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEE 574
            :||            .|||.|...|:|:::.|.::|  .|...|..:|
Yeast   478 TRKELWRKEQKLQTVLETLLSDVNQNQRNVNETMSR--SLANGIINVK----------------- 523

  Fly   575 RNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAIS 639
                        ||.|:                 :::..|    .:.|.||:|..::.||.....
Yeast   524 ------------EITEK-----------------LKISPE----SVFGTLGELIKVNDKYKTCAE 555

  Fly   640 TACGR-LDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPR----- 698
            ...|. |.:||.|..|||:..:..|.....||.|||.|:::     ..:|.:..|.|...
Yeast   556 VIGGNSLFHIVVDTEETATLIMNELYRMKGGRVTFIPLNRL-----SLDSDVKFPSNTTTQIQFT 615

  Fly   699 -LYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSR 762
             |...:|.| .|...|.......|:|..||.||.::| .:.:...:||.|:..:..|.::|
Yeast   616 PLIKKIKYE-PRFEKAVKHVFGKTIVVKDLGQGLKLA-KKHKLNAITLDGDRADKRGVLTG---- 674

  Fly   763 PIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQR 827
               |.:....||:              ||.::        .:|..:.|...:..|:..::|.|..
Yeast   675 ---GYLDQHKRTR--------------LESLK--------NLNESRSQHKKILEELDFVRNELND 714

  Fly   828 DEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQ---- 888
            .:.:..::..:|..:.....|.|...|..|..:..|..::..:   ||.:.|...:||:..
Yeast   715 IDTKIDQVNGNIRKVSNDRESVLTNIEVYRTSLNTKKNEKLIL---EESLNAIILKLEKLNTNRT 776

  Fly   889 FAEQAVSSQIEEIQNQYDT-LRNESVKPVEAKIKKVNS----------QIEKLAANVRSLNVGLA 942
            ||::.:::...::..::|: |..|..:.:|:..|::::          .:|.:...:.|||..|.
Yeast   777 FAQEKLNTFENDLLQEFDSELSKEEKERLESLTKEISAAHNKLNITSDALEGITTTIDSLNAELE 841

  Fly   943 TADRNITKITGNNNNLREN--------IKAAEEKLKSLNEDRNKAKEKKEE-------LEKEIE- 991
                  :|:....|:|...        |...:::||.|..::...:::.|.       :::|||
Yeast   842 ------SKLIPQENDLESKMSEVGDAFIFGLQDELKELQLEKESVEKQHENAVLELGTVQREIES 900

  Fly   992 ------ESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQ 1050
                  .::..:|.|.:|...:.|::|...|...|..|::..:.|:.:....::.::
Yeast   901 LIAEETNNKKLLEKANNQQRLLLKKLDNFQKSVEKTMIKKTTLVTRREELQQRIREI-------- 957

  Fly  1051 AQLAP--LKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNE 1113
             .|.|  ..:|:....|..|. |:.||:...|...|:             ...|......|:|||
Yeast   958 -GLLPEDALVNDFSDITSDQL-LQRLNDMNTEISGLK-------------NVNKRAFENFKKFNE 1007

  Fly  1114 KRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAEL-- 1176
            :|....:|...|::   .::.::|...::::::.......|..::...:.:::.:...|.|:|
Yeast  1008 RRKDLAERASELDE---SKDSIQDLIVKLKQQKVNAVDSTFQKVSENFEAVFERLVPRGTAKLII 1069

  Fly  1177 -----------ELVD-SMDPFTE-------------GVNFTV--RPPKKSWKYISNLSGGEKTLS 1214
                       |.:| .||..:.             ||:.:|  ...:....::..||||:||:.
Yeast  1070 HRKNDNANDHDESIDVDMDAESNESQNGKDSEIMYTGVSISVSFNSKQNEQLHVEQLSGGQKTVC 1134

  Fly  1215 SLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVG 1279
            ::||:.|:....|:..|..||||||||.:..:.|...:||.:||||||..:.|.:|.::|
Yeast  1135 AIALILAIQMVDPASFYLFDEIDAALDKQYRTAVATLLKELSKNAQFICTTFRTDMLQVA----- 1194

  Fly  1280 IYKVSDCTDSITMLNYPPTLPTQSPVVANSQYVGGTIEGDNTIA 1323
                    |....:.|...:.|  .:..|.:...|.|.|.|..|
Yeast  1195 --------DKFFRVKYENKIST--VIEVNREEAIGFIRGSNKFA 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	288/1369 (21%)
SMC3	NP_012461.1	SMC_N	2..1208	CDD:426784	290/1384 (21%)