Protein Alignment glu and SMC6

DIOPT Version :9

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_013487.1
• Gene: SMC6 / 851099
• SGDID: S000004375
• Length: 1114
• Species: Saccharomyces cerevisiae
• Alignment Length: 1382
• Identity: 271/1382 - (19%)
• Similarity: 492/1382 - (35%)
• Gaps: 466/1382 - (33%)

  Fly    28 LTAQQQLRAQQQQE------------------EEDAAVDALDDALIFDDEEGGTRIGDIYIPPPV 74
            |||||:...||||.                  :||:...:..|....|.:
Yeast    22 LTAQQENEEQQQQRKRRRHQFAPMTQFNSNTLDEDSGFRSSSDVATADQD--------------- 71

  Fly    75 PPHCSMESTGPRLIISKIVNRNFKSYAG-EVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCR 138
                :.....|...|.|::.|||..:.. |:|||   .....|:|.||||||.::.::....|.:
Yeast    72 ----NFLEESPSGYIKKVILRNFMCHEHFELELG---SRLNFIVGNNGSGKSAILTAITIGLGAK 129

  Fly   139 ANRI-RCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYY 202
            |:.. |...:..||..     ...|..:.:|...  .|.....:.:..:.|::||....|..:.:
Yeast   130 ASETNRGSSLKDLIRE-----GCYSAKIILHLDN--SKYGAYQQGIFGNEIIVERIIKRDGPASF 187

  Fly   203 --------QINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKP---------KGQ-- 248
                    :|::|:   ||:..::....|.:.:....:.|....|......         ||.
Yeast   188 SLRSENGKEISNKK---KDIQTVVDYFSVPVSNPMCFLSQDAARSFLTASTSQDKYSHFMKGTLL 249

  Fly   249 ---TEN-----------ETGMLEYLEDIVGTQRYIRPLQQINQRVDQLTDDRTEK---------- 289
               |||           :..|..:||::...:......:::.:.::|.:|....|
Yeast   250 QEITENLLYASAIHDSAQENMALHLENLKSLKAEYEDAKKLLRELNQTSDLNERKMLLQAKSLWI 314

  Fly   290 ---HN--RCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQEHEAC 349
               ||  .||..|.|:..::|..:|..:.::...|                  |:|:||
Yeast   315 DVAHNTDACKNLENEISGIQQKVDEVTEKIRNRQE------------------KIERYT------ 355

  Fly   350 AEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNK 414
                   .:||....|..|:...:..|:.|...|....|: :|.|....:|...|.||   |.::
Yeast   356 -------SDGTTIEAQIDAKVIYVNEKDSEHQNARELLRD-VKSRFEKEKSNQAEAQS---NIDQ 409

  Fly   415 QRKK---------------------DKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSK 458
            .|||                     ||.|:   .:|||.|.|..|| .||:.  |..:.||:..|
Yeast   410 GRKKVDALNKTIAHLEEELTKEMGGDKDQM---RQELEQLEKANEK-LREVN--NSLVVSLQDVK 468

  Fly   459 VTLNEELE---KQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGE---VQVFESQL-KILKQ 516
               |||.:   ::::||...:..:..|:::|.          |.|||.   :..|:..: ::|:
Yeast   469 ---NEERDIQHERESELRTISRSIQNKKVELQ----------NIAKGNDTFLMNFDRNMDRLLR- 519

  Fly   517 AETTESRKYE-------------TLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVD 568
              |.|.||.|             |::..:|:..:|::..::                :|.:|.|.
Yeast   520 --TIEQRKNEFETPAIGPLGSLVTIRKGFEKWTRSIQRAIS----------------SSLNAFVV 566

  Fly   569 KMVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAK 633
            ...|:        |:|..:|.....:    |||..::.:.:                      ::
Yeast   567 SNPKD--------NRLFRDIMRSCGI----RSNIPIVTYCL----------------------SQ 597

  Fly   634 YDIAISTACGRLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPR 698
            :|.:...|.|....|| |..|.:...|..|         |:.|.:||.
Yeast   598 FDYSKGRAHGNYPTIV-DALEFSKPEIECL---------FVDLSRIER----------------- 635

  Fly   699 LYDLVKVEDDRVRTAFYFALRN------TLVCDDLEQGTRIAYGRERYRVVTLRGEMIEMTGTMS 757
               :|.:||.  ..|..|..||      .|...|...|.:::.|   ||:.|:..:
Yeast   636 ---IVLIEDK--NEARNFLQRNPVNVNMALSLRDRRSGFQLSGG---YRLDTVTYQ--------- 683

  Fly   758 GGGSRPIRGKMGTQVRTKTAESADSSQISQKALEDM-QIQAEELQARVNYCQEQQGSLEREIQTL 821
                        .::|.|...|:|:   ..:.|:|: :.:.:|||...:..:|:...:...::.:
Yeast   684 ------------DKIRLKVNSSSDN---GTQYLKDLIEQETKELQNIRDRYEEKLSEVRSRLKEI 733

  Fly   822 KNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQI---EAAKQE 883
            ...|:..:.|.::....:|.|:..:.      :.....:|....:||  |.:|:.|   ||||:|
Yeast   734 DGRLKSTKNEMRKTNFRMTELKMNVG------KVVDTGILNSKINER--KNQEQAIASYEAAKEE 790

  Fly   884 --LEQAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADR 946
              |:..|.|::|     :.|:.|||:          .|:..|.:|.|.
Yeast   791 LGLKIEQIAQEA-----QPIKEQYDS----------TKLALVEAQDEL----------------- 823

  Fly   947 NITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEI 1011
                     ..|:|:|.:.:.|::...:|....::||:...:.|::.|.::...|   ..|:::|
Yeast   824 ---------QQLKEDINSRQSKIQKYKDDTIYYEDKKKVYLENIKKIEVNVAALK---EGIQRQI 876

  Fly  1012 DEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNE 1076
            .......:|..||.:                  |:|..|
Yeast   877 QNACAFCSKERIENV------------------DLPDTQ-------------------------- 897

  Fly  1077 EELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEE 1141
                               |::|.:...:|.:.:..||.|....     |::.:...:.|:||:|
Yeast   898 -------------------EEIKRELDKVSRMIQKAEKSLGLSQ-----EEVIALFEKCRNKYKE 938

  Fly  1142 VRKRRYKEFMDGFSIITRKLK---EMYQMITLGG--DAELELVDSMD--PFTEGVNFTVRPPKKS 1199
            .:| :|.|..:..:.:...||   :.|:....|.  ||:::...|:.  .|:..::| ::..|..
Yeast   939 GQK-KYMEIDEALNRLHNSLKARDQNYKNAEKGTCFDADMDFRASLKVRKFSGNLSF-IKDTKSL 1001

  Fly  1200 WKYI-----------SNLSGGEKTLSSLALVFALHYYKP--SPLYFMDEIDAALDFKNVSIVGHY 1251
            ..||           ..||||||:.|.:||:.|.  :||  |.:..:||.|..:|..|..|....
Yeast  1002 EIYILTTNDEKARNVDTLSGGEKSFSQMALLLAT--WKPMRSRIIALDEFDVFMDQVNRKIGTTL 1064

  Fly  1252 IKERTKN---AQFIIVS 1265
            |.::.|:   .|.||::
Yeast  1065 IVKKLKDIARTQTIIIT 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	36/177 (20%)
		Smc	89..1281	CDD:224117	257/1303 (20%)
		SMC_hinge	618..733	CDD:214944	23/120 (19%)
		ATP-synt_B	<825..904	CDD:304375	20/83 (24%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	27/86 (31%)
SMC6	NP_013487.1	Smc	81..1101	CDD:224117	257/1304 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900