DRSC/TRiP Functional Genomics Resources

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Protein Alignment glu and SMC4

DIOPT Version :9

Sequence 1:NP_723996.1 Gene:glu / 35001 FlyBaseID:FBgn0015391 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_013187.1 Gene:SMC4 / 850775 SGDID:S000004076 Length:1418 Species:Saccharomyces cerevisiae


Alignment Length:1402 Identity:489/1402 - (34%)
Similarity:776/1402 - (55%) Gaps:192/1402 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PSKGTPKAAGGARQSGQF-----RVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRI 65
            |:...||.:...|....:     |.|..:..::|...|....:::.|:                :
Yeast    89 PNLQPPKTSSRGRDHKSYSQSPPRSPGRSPTRRLELLQLSPVKNSRVE----------------L 137

  Fly    66 GDIYIPPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDS 130
            ..||     ..|.|......||.|:::|..|||||||:..:||||.||:|::|||||||||||||
Yeast   138 QKIY-----DRHQSSSKQQSRLFINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDS 197

  Fly   131 MMFVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCE-DVPDSSIVIERTA 194
            |:||||.|||::|..|:|.|||.|.::|:|:||||||||:.::|:..||.. |.....::|.|.|
Yeast   198 MLFVFGFRANKMRQDRLSDLIHKSEAFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPGLIITRKA 262

  Fly   195 MSDNSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYL 259
            ..:|||.|.||:|.:...:|.||||...:||:|.||||||||||:||.||||.:.|::.|:||||
Yeast   263 FKNNSSKYYINEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYL 327

  Fly   260 EDIVGTQRYIRPLQQINQR---VDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENE-- 319
            |||:||..| :||  |.:|   ::.|.:...||.||.::.:||...||.....|:::|:||.:  
Yeast   328 EDIIGTANY-KPL--IEERMGQIENLNEVCLEKENRFEIVDREKNSLESGKETALEFLEKEKQLT 389

  Fly   320 LVRTKSFHIQKIISIKK--SKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEE-- 380
            |:|:|.|..:.:.|..|  |.||:.:..::...:|.....|....:.:.:|:     ||||::  
Yeast   390 LLRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQ-----RKEIKDRI 449

  Fly   381 ------YEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEK 439
                  .:.||.:|.:::...|::|.....:.|.||...|..|..|..|.:.|..||:|.....:
Yeast   450 SSCSSKEKTLVLERRELEGTRVSLEERTKNLVSKMEKAEKTLKSTKHSISEAENMLEELRGQQTE 514

  Fly   440 NQREIEDCNKKLES----LEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTA 500
            ::.||:|..:.||.    |:..|::|.::.:...||:.:     .||.|:..|  :.|:||    
Yeast   515 HETEIKDLTQLLEKERSILDDIKLSLKDKTKNISAEIIR-----HEKELEPWD--LQLQEK---- 568

  Fly   501 KGEVQVFESQLKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIAS--- 562
            :.::|:.||:|.:|::.:....:..|||:......:...:|....:.:||:.:..:|.|.:.   
Yeast   569 ESQIQLAESELSLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKDERSQGEK 633

  Fly   563 -------KSAEVDKMVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGI 620
                   |..|:.|::...|..:|:.         |||:.:|| :.:|||..|.|::..|:|.|.
Yeast   634 NFTSAHLKLKEMQKVLNAHRQRAMEA---------RSSLSKAQ-NKSKVLTALSRLQKSGRINGF 688

  Fly   621 LGRLGDLGGIDAKYDIAISTACGRLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRRE 685
            .|||||||.||..:|:||||||.|||::|.|..|.|...|..|::..:|.|.||.||::    |:
Yeast   689 HGRLGDLGVIDDSFDVAISTACPRLDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRL----RQ 749

  Fly   686 ANSR-INTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEM 749
            .|.: |:||||||||:||||.::.:...|||..||:|||..:|:|...:|||::|:||||:.|::
Yeast   750 FNLQPISTPENVPRLFDLVKPKNPKFSNAFYSVLRDTLVAQNLKQANNVAYGKKRFRVVTVDGKL 814

  Fly   750 IEMTGTMSGGGSRPIRG--KMGT---------------QVRTKTAESADSSQISQKALEDMQIQA 797
            |:::|||||||:...:|  |:||               ::..:.:|..::.:::...:.:|:.:.
Yeast   815 IDISGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDKIERELSERENNFRVASDTVHEMEEEL 879

  Fly   798 E-------ELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEA 855
            :       :|:::::..:.:..||..|:...:..::..|..|.: |||..:....:..||::...
Yeast   880 KKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAEMAYVK-AVSDKAQLNVVMKNLERLRG 943

  Fly   856 QRQRMLKKTTDERAVKEREEQIEAAKQELEQ-AQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAK 919
            :...:..:|      |.::|:|:..:.|:.: .....|..:|::|.:..:.|.|        .||
Yeast   944 EYNDLQSET------KTKKEKIKGLQDEIMKIGGIKLQMQNSKVESVCQKLDIL--------VAK 994

  Fly   920 IKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLK-----------SLN 973
            :|||.|..:|...:|......|..::|::...:       :.:|..||:||           ::|
Yeast   995 LKKVKSASKKSGGDVVKFQKLLQNSERDVELSS-------DELKVIEEQLKHTKLALAENDTNMN 1052

  Fly   974 EDRN---KAKEKKEELEKEIEESEASIEGAKSQSSDIKKEID-----------EITKEE---NKR 1021
            |..|   :.||:.|:|::::|:.|.||...||...::|.:::           |||::|   |:.
Yeast  1053 ETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKGLNEL 1117

  Fly  1022 NIERIEIDTKLQAAAGKMNKVKNDIPGWQ-------------------AQLA-----PLKLNEIP 1062
            :|..: ..|.......||:.||.|:...|                   |:.:     |:.::|..
Yeast  1118 SIRDV-THTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDAETSCDNYHPMNIDETS 1181

  Fly  1063 GETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLED 1127
            .|.....|  .|:|:||....:|.::.|...|...::....::..::|:..:...:..|...|.:
Yeast  1182 DEVSRGIP--RLSEDELRELDVELIESKINELSYYVEETNVDIGVLEEYARRLAEFKRRKLDLNN 1244

  Fly  1128 ITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFT 1192
            ...||:|::::...::|:|:.|||.||:||:..|||||||||:||:||||||||:|||:|||.|:
Yeast  1245 AVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMGGNAELELVDSLDPFSEGVTFS 1309

  Fly  1193 VRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTK 1257
            |.||||||:.|:|||||||||||||||||||.|||:|||.||||||||||:|||||.:|||||||
Yeast  1310 VMPPKKSWRNITNLSGGEKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTK 1374

  Fly  1258 NAQFIIVSLRVNMFELANFLVGIYKVSDCTDSITMLN 1294
            |||||::|||.||||||..|||:||..:.|.|.|:.|
Yeast  1375 NAQFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKN 1411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gluNP_723996.1 ABC_SMC4_euk 87..>246 CDD:213241 91/159 (57%)
Smc 89..1281 CDD:224117 468/1299 (36%)
SMC_hinge 618..733 CDD:214944 57/115 (50%)
ATP-synt_B <825..904 CDD:304375 15/79 (19%)
ABC_SMC4_euk <1196..1290 CDD:213241 73/93 (78%)
SMC4NP_013187.1 Smc 154..1418 CDD:224117 475/1316 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345426
Domainoid 1 1.000 711 1.000 Domainoid score I9
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4015
Inparanoid 1 1.050 724 1.000 Inparanoid score I86
Isobase 1 0.950 - 0 Normalized mean entropy S1360
OMA 1 1.010 - - QHG54018
OrthoFinder 1 1.000 - - FOG0003579
OrthoInspector 1 1.000 - - oto100211
orthoMCL 1 0.900 - - OOG6_101113
Panther 1 1.100 - - LDO PTHR43939
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1354
SonicParanoid 1 1.000 - - X3446
TreeFam 1 0.960 - -
1615.740

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