Protein Alignment glu and SMC2

DIOPT Version :9

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_116687.1
• Gene: SMC2 / 850589
• SGDID: S000001927
• Length: 1170
• Species: Saccharomyces cerevisiae
• Alignment Length: 1310
• Identity: 312/1310 - (23%)
• Similarity: 575/1310 - (43%)
• Gaps: 282/1310 - (21%)

  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRA-NRIRCKRVSTLIH 152
            :.:::...|||||....:..:...|.||.|.|||||||::|::.||.|..: :.:|...:..||:
Yeast     3 VEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQDLIY 67

  Fly   153 SSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKL 217
            .... ..:...||.:.|.. .||.:..........|.:.|..:...:|.|.||..||..:.|.:|
Yeast    68 KRGQ-AGVTKASVTIVFDN-TDKSNSPIGFTNSPQISVTRQVVLGGTSKYLINGHRAPQQSVLQL 130

  Fly   218 LKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQL 282
            .:...:::.:..|||:||::..:..|||       :.:|..:|:..||:.:
Yeast   131 FQSVQLNINNPNFLIMQGKITKVLNMKP-------SEILSLIEEAAGTKMF-------------- 174

  Fly   283 TDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQEHE 347
             :||.||      |||.|.             |||.:|...::...::|    :.|||:...|..
Yeast   175 -EDRREK------AERTMS-------------KKETKLQENRTLLTEEI----EPKLEKLRNEKR 215

  Fly   348 ACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENT 412
            ...|...|                   :.::|:.|.:|     :......::..:|.|:.|:||.
Yeast   216 MFLEFQST-------------------QTDLEKTERIV-----VSYEYYNIKHKHTSIRETLENG 256

  Fly   413 NKQRKKDKAQIEKNEKELEDLH------KLPEKNQREIEDCNKKLE---------------SLEV 456
            ..:.|.....::|..:|::.|:      ||.::.:...|....|||               ||.:
Yeast   257 ETRMKMLNEFVKKTSEEIDSLNEDVEEIKLQKEKELHKEGTISKLENKENGLLNEISRLKTSLSI 321

  Fly   457 SKVTLNEELEKQQA---ELTKTTAPLTEKR-----------------------LKLSDELV---- 491
            ....||:..||.:|   |:..::|.|.||:                       .|..:|||
Yeast   322 KVENLNDTTEKSKALESEIASSSAKLIEKKSAYANTEKDYKMVQEQLSKQRDLYKRKEELVSTLT 386

  Fly   492 -GLKE--------KVNTAKGEVQVFESQLKILKQAETTESRKYE--TLKSSYEQSQKSLEEKVTR 545
             |:..        ....||.:.::.|..|.|.|.:...|..|.|  |::...:::.|..|..|..
Yeast   387 TGISSTGAADGGYNAQLAKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKEATKDNELNVKH 451

  Fly   546 VDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEINE--RSSVMQAQRSNNKVLDFL 608
            |.:.:|:..:::..:.....:..::    ::|..:.:||::...:  ::|....:|..|...::.
Yeast   452 VKQCQETCDKLRARLVEYGFDPSRI----KDLKQREDKLKSHYYQTCKNSEYLKRRVTNLEFNYT 512

  Fly   609 MRM-KMEGK-IPGILGRLGDLGGIDAKYDIAIST-ACGRLDNIVTDNYETASAAI--GALKEYNV 668
            ... ..|.. :.|::|:|..:...:.:|..|:.| |.|||.|:|..:.:||:..:  |.|::
Yeast   513 KPYPNFEASFVHGVVGQLFQIDNDNIRYATALQTCAGGRLFNVVVQDSQTATQLLERGRLRK--- 574

  Fly   669 GRATFITLDKIEHHRREANSRI------NTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDL 727
             |.|.|.||||  :.|..:|::      ..|..|....:|::. |:.:..|..|...|:|:|:|.
Yeast   575 -RVTIIPLDKI--YTRPISSQVLDLAKKIAPGKVELAINLIRF-DESITKAMEFIFGNSLICEDP 635

  Fly   728 EQGTRIAY-GRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAES--ADSSQISQKA 789
            |...:|.: .:.|.|.:||:|::.:..||:| ||||            .|:||  .|..:.:|
Yeast   636 ETAKKITFHPKIRARSITLQGDVYDPEGTLS-GGSR------------NTSESLLVDIQKYNQ-- 685

  Fly   790 LEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLE----------- 843
               :|.|.|.:||.:|:..|       |:||.....|:.:.....|.:|:..|:
Yeast   686 ---IQKQIETIQADLNHVTE-------ELQTQYATSQKTKTIQSDLNLSLHKLDLAKRNLDANPS 740

  Fly   844 -------QQMASNLKQCEAQ---RQRMLKK-----TTDERAVKEREEQIEAAKQEL-EQAQFAEQ 892
                   :::..::.:||.:   :|..|||     :|.|:.:||.:....:...|| ::.:...:
Yeast   741 SQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYDSDKGSKLNELKKELKLLAK 805

  Fly   893 AVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNN 957
            .:..|..|.:.:||..:|     :|.:.::::|:::   :|...|:..|    ::|..:...|::
Yeast   806 ELEEQESESERKYDLFQN-----LELETEQLSSELD---SNKTLLHNHL----KSIESLKLENSD 858

  Fly   958 LRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASI----EGAKSQSSDIKKEIDEITK-E 1017
            |...|:..|:.|.::..:.|:.|::..:::.|:.|.|..|    :..||...:::|.:.::.| :
Yeast   859 LEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELELQKLVHDLNKYK 923

  Fly  1018 ENKRNIERIEIDTKLQ-AAAGKMNKVKNDIPGWQAQLAPLKLNE-IPGETEPQAPLKELNE--EE 1078
            .|..|:|:|..|.:.: ......:.|:|.:          |.|| |..:|..:.. |:|||  :|
Yeast   924 SNTNNMEKIIEDLRQKHEFLEDFDLVRNIV----------KQNEGIDLDTYRERS-KQLNEKFQE 977

  Fly  1079 LEAET-------LEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMR 1136
            |..:.       :|.::.|:..|:..:||                :..|::::.|.| ||.||.
Yeast   978 LRKKVNPNIMNMIENVEKKEAALKTMIKT----------------IEKDKMKIQETI-SKLNEY- 1024

  Fly  1137 DKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWK 1201
             |.|.:.|...|..:|..:|....|...:        |:|...:..| .|:|:...|: ....||
Yeast  1025 -KRETLVKTWEKVTLDFGNIFADLLPNSF--------AKLVPCEGKD-VTQGLEVKVK-LGNIWK 1078

  Fly  1202 -YISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVS 1265
             .:..||||:::|.:|:|:.||..::|:|:|.:||:|||||..:...:||.||.|.|.:|||:||
Yeast  1079 ESLIELSGGQRSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVS 1143

  Fly  1266 LRVNMFELAN 1275
            |:..||..||
Yeast  1144 LKEGMFANAN 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	45/157 (29%)
		Smc	89..1281	CDD:224117	312/1310 (24%)
		SMC_hinge	618..733	CDD:214944	36/123 (29%)
		ATP-synt_B	<825..904	CDD:304375	18/105 (17%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	37/81 (46%)
SMC2	NP_116687.1	Smc	1..1169	CDD:224117	312/1310 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810